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Stefan Hohmann

Researcher at Chalmers University of Technology

Publications -  205
Citations -  16932

Stefan Hohmann is an academic researcher from Chalmers University of Technology. The author has contributed to research in topics: Saccharomyces cerevisiae & Osmotic shock. The author has an hindex of 62, co-authored 204 publications receiving 15988 citations. Previous affiliations of Stefan Hohmann include University of the Free State & Technische Universität Darmstadt.

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Journal ArticleDOI

Osmotic Stress Signaling and Osmoadaptation in Yeasts

TL;DR: An integrated understanding of osmoadaptation requires not only knowledge of the function of many uncharacterized genes but also further insight into the time line of events, their interdependence, their dynamics, and their spatial organization as well as the importance of subtle effects.
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The complete DNA sequence of yeast chromosome III.

Stephen G. Oliver, +146 more
- 07 May 1992 - 
TL;DR: The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined, which is the first complete sequence analysis of an entire chromosome from any organism.
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GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway.

TL;DR: Hog1 delta mutants lacking a protein kinase involved in osmostress-induced signal transduction failed to increase glycerol-3-phosphate dehydrogenase activity and mRNA levels when osmotic stress was imposed, suggesting the HOG pathway most probably has additional targets in the mechanism of adaptation to hypertonic medium.
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The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes.

TL;DR: In this article, the authors analyzed the transcriptional response to osmotic shock in the yeast Saccharomyces cerevisiae and found that the mRNA level of 186 genes increased at least 3-fold after a shift to NaCl or sorbitol whereas that of more than 100 genes was at least 1.5-fold diminished.
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The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation

TL;DR: It is concluded that expression of GPD2 is controlled by a novel, oxygen‐independent, signalling pathway which is required to regulate metabolism under anoxic conditions.