Stephen C. Pak

TL;DR: In this paper, the authors present methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein aggregate (APA) compound selected from the group consisting of pimozide, fluphenazine (e.g., fluphensazine hydrochloride), tamoxifen, tamoxifyen citrate, taxol, cantharidin, canthyodorin, and taxol salts thereof and their structurally related compounds.

TL;DR: This work constructed an IGF-I heterologous gene driven by the cytomegalovirus promoter, introduced it into Chinese Hamster Ovary cells, and examined the growth characteristics of Insulin-like growth factor I-expressing clonal cells in the absence of the exogenous factor.

TL;DR: A computational model of coupled apoptosis and autophagy is built here to study the systems-level dynamics of the underlying signaling network and identified Ca2+/calmodulin-dependent kinase kinase β (CaMKKβ) as a determinant of the opposite roles of cytoplasmic Ca2+.

TL;DR: The endogenous lysosomal cysteine protease inhibitor SERPINB3 (squamous cell carcinoma antigen 1, SCCA1) is elevated in patients with cervical cancer and other malignancies as discussed by the authors .

TL;DR: (The American Journal of Human Genetics 105, 413–424; August 1, 2019)