S
Stephen C. Pak
Researcher at Washington University in St. Louis
Publications - 71
Citations - 7712
Stephen C. Pak is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Serpin & Caenorhabditis elegans. The author has an hindex of 27, co-authored 63 publications receiving 6933 citations. Previous affiliations of Stephen C. Pak include Boston Children's Hospital & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.
Brett V. Johnson,Raman Kumar,Sabrina Oishi,Suzy Alexander,Suzy Alexander,Maria Kasherman,Maria Kasherman,Michelle C. Sanchez Vega,Atma M. Ivancevic,Atma M. Ivancevic,Alison Gardner,Deepti Domingo,Mark A. Corbett,Euan Parnell,Sehyoun Yoon,Tracey Oh,Matthew A. Lines,Henrietta Lefroy,Usha Kini,Margot I. Van Allen,Sabine Grønborg,Sandra Mercier,Sébastien Küry,Stéphane Bézieau,Laurent Pasquier,Martine Raynaud,Alexandra Afenjar,Thierry Billette de Villemeur,Boris Keren,Julie Désir,Lionel Van Maldergem,Martina Marangoni,Nicola Dikow,David A. Koolen,Peter M. VanHasselt,Marjan M. Weiss,Petra J. G. Zwijnenburg,Joaquim Sa,Claudia Falcao Reis,Carlos López-Otín,Olaya Santiago-Fernández,Alberto Fernández-Jaen,Anita Rauch,Katharina Steindl,Pascal Joset,Amy Goldstein,Suneeta Madan-Khetarpal,Elena Infante,Elaine H. Zackai,Carey McDougall,Vinodh Narayanan,Keri Ramsey,Saadet Mercimek-Andrews,Loren D M Pena,Vandana Shashi,Kelly Schoch,Jennifer A. Sullivan,Maria T. Acosta,David R. Adams,Aaron Aday,Mercedes E. Alejandro,Patrick Allard,Euan A. Ashley,Mahshid S. Azamian,Carlos A. Bacino,Guney Bademci,Eva Baker,Ashok Balasubramanyam,Dustin Baldridge,Deborah Barbouth,Gabriel F. Batzli,Alan H. Beggs,Hugo J. Bellen,Jonathan A. Bernstein,Gerard T. Berry,Anna Bican,David P. Bick,Camille L. Birch,Stephanie Bivona,Carsten Bonnenmann,Devon Bonner,Braden E. Boone,Bret L. Bostwick,Lauren C. Briere,Elly Brokamp,Donna M. Brown,Matthew Brush,Elizabeth A. Burke,Lindsay C. Burrage,Manish J. Butte,Olveen Carrasquillo,Ta Chen Peter Chang,Hsiao-Tuan Chao,Gary D. Clark,Terra R. Coakley,Laurel A. Cobban,Joy D. Cogan,F. Sessions Cole,Heather A. Colley,Cynthia M. Cooper,Heidi Cope,William J. Craigen,Precilla D'Souza,Surendra Dasari,Mariska Davids,Jean M. Davidson,Jyoti G. Dayal,Esteban C. Dell'Angelica,Shweta U. Dhar,Naghmeh Dorrani,Daniel C. Dorset,Emilie D. Douine,David D. Draper,Annika M. Dries,Laura Duncan,David J. Eckstein,Lisa Emrick,Christine M. Eng,Gregory M. Enns,Cecilia Esteves,Tyra Estwick,Liliana Fernandez,Carlos Ferreira,Elizabeth L. Fieg,Paul G. Fisher,Brent L. Fogel,Irman Forghani,Noah D. Friedman,William A. Gahl,Rena A. Godfrey,Alica M. Goldman,David Goldstein,Jean-Philippe F. Gourdine,Alana L. Grajewski,Catherine Groden,Andrea L. Gropman,Melissa A. Haendel,Rizwan Hamid,Neil A. Hanchard,Frances A. High,Ingrid A. Holm,Jason Hom,Alden Y. Huang,Yong Huang,Rosario Isasi,Fariha Jamal,Yong-hui Jiang,Jean M. Johnston,Angela Jones,Lefkothea P. Karaviti,Emily G. Kelley,David M. Koeller,Isaac S. Kohane,Jennefer N. Kohler,Deborah Krakow,Donna M. Krasnewich,Susan A. Korrick,Mary Koziura,Joel B. Krier,Jennifer E. Kyle,Seema R. Lalani,Byron L. Lam,Brendan C. Lanpher,Ian R. Lanza,C. Christopher Lau,Jozef Lazar,Kimberly LeBlanc,Brendan Lee,Hane Lee,Roy C. Levitt,Shawn Levy,Richard A. Lewis,Sharyn A. Lincoln,Pengfei Liu,Xue Zhong Liu,Sandra K. Loo,Joseph Loscalzo,Richard L. Maas,Ellen Macnamara,Calum A. MacRae,Valerie Maduro,Marta M. Majcherska,May Christine V. Malicdan,Laura A. Mamounas,Teri A. Manolio,Thomas C. Markello,Ronit Marom,Martin G. Martin,Julian A. Martinez-Agosto,Shruti Marwaha,Thomas May,Jacob L. McCauley,Allyn McConkie-Rosell,Colleen E. McCormack,Alexa T. McCray,Jason D. Merker,Thomas O. Metz,Matthew Might,Eva Morava-Kozicz,Paolo Moretti,Marie Morimoto,John J.E. Mulvihill,David R. Murdock,Avi Nath,Stan F. Nelson,J. Scott Newberry,John H. Newman,Sarah K. Nicholas,Donna Novacic,Devin Oglesbee,James P. Orengo,Stephen C. Pak,J. Carl Pallais,Christina G.S. Palmer,Jeanette C. Papp,Neil H. Parker,John A. Phillips,Jennifer E. Posey,John H. Postlethwait,Lorraine Potocki,Barbara N. Pusey,Genecee Renteri,Chloe M. Reuter,Lynette Rives,Amy K. Robertson,Lance H. Rodan,Jill A. Rosenfeld,Robb Rowley,Ralph L. Sacco,Jacinda B. Sampson,Susan L. Samson,Mario Saporta,Judy Schaechter,Tim Schedl,Daryl A. Scott,Lisa Shakachite,Prashant Sharma,Kathleen Shields,Jimann Shin,Rebecca Signer,Catherine H. Sillari,Edwin K. Silverman,Janet S. Sinsheimer,Kevin S. Smith,Lilianna Solnica-Krezel,Rebecca C. Spillmann,Joan M. Stoler,Nicholas Stong,David A. Sweetser,Cecelia P. Tamburro,Queenie K.-G. Tan,Mustafa Tekin,Fred F. Telischi,Willa Thorson,Cynthia J. Tifft,Camilo Toro,Alyssa A. Tran,Tiina K. Urv,Tiphanie P. Vogel,Daryl Waggott,Colleen E. Wahl,Nicole M. Walley,Christopher A. Walsh,Melissa A. Walker,Jennifer A. Wambach,Jijun Wan,Lee-kai Wang,Michael F. Wangler,Patricia A. Ward,Katrina M. Waters,Bobbie-Jo M. Webb-Robertson,Daniel J. Wegner,Monte Westerfield,Matthew T. Wheeler,Anastasia L. Wise,Lynne A. Wolfe,Jeremy D. Woods,Elizabeth A. Worthey,Shinya Yamamoto,John Yang,Amanda J. Yoon,Guoyun Yu,Diane B. Zastrow,Chunli Zhao,Stephan Züchner,William Gahl,Filippo Vairo,Pavel N. Pichurin,Sarah Ewing,Sarah S. Barnett,Eric W. Klee,M. Scott Perry,Mary Kay Koenig,Catherine E. Keegan,Jane L. Schuette,Stephanie Byers Asher,Yezmin Perilla-Young,Laurie D. Smith,Elizabeth J. Bhoj,Paige Kaplan,Dong Li,Renske Oegema,Ellen van Binsbergen,Bert van der Zwaag,Marie Falkenberg Smeland,Ioana Cutcutache,Matthew Page,Martin Armstrong,Angela E. Lin,Marcie A. Steeves,Nicolette S. den Hollander,Mariëtte J.V. Hoffer,Margot R.F. Reijnders,Serwet Demirdas,Daniel C. Koboldt,Dennis Bartholomew,Theresa Mihalic Mosher,Scott E. Hickey,Christine Shieh,Pedro A. Sanchez-Lara,John M. Graham,Kamer Tezcan,G.B. Schaefer,Noelle R. Danylchuk,Alexander Asamoah,Kelly E. Jackson,Naomi Yachelevich,Margaret G. Au,Luis A. Pérez-Jurado,Tjitske Kleefstra,Peter Penzes,Stephen A. Wood,Thomas H. J. Burne,Thomas H. J. Burne,Tyler Mark Pierson,Michael Piper,Jozef Gecz,Lachlan A. Jolly +337 more
TL;DR: The involvement of USP9X variants in a distinctive neurodevelopmental and behavioral syndrome in male subjects is demonstrated and plausible mechanisms of pathogenesis centered on disrupted transforming growth factor β signaling and hippocampal function are identified.
Journal ArticleDOI
A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover
Olivia S. Long,Joshua A. Benson,Joon Hyeok Kwak,Cliff J. Luke,Sager J. Gosai,Linda P. O’Reilly,Yan Wang,Jie Li,Anne C. Vetica,Mark T. Miedel,Donna B. Stolz,Simon C. Watkins,Stephan Züchner,David H. Perlmutter,Gary A. Silverman,Stephen C. Pak +15 more
TL;DR: Two studies allude to the existence of a novel proteostasis pathway that mechanistically links misfolded protein turnover to components of the systemic RNAi machinery.
Journal ArticleDOI
Quantitative assessment of cell fate decision between autophagy and apoptosis
Bing Liu,Zoltán N. Oltvai,Hülya Bayır,Gary A. Silverman,Stephen C. Pak,David H. Perlmutter,Ivet Bahar +6 more
TL;DR: A computational model of coupled apoptosis and autophagy is built here to analyze the underlying signaling and regulatory network dynamics and reveals that cytoplasmic Ca2+ acts as a rheostat that fine-tunes autophagic and apoptotic responses.
Journal ArticleDOI
Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype.
TL;DR: In this paper, the authors use α1-antitrypsin deficiency (ATD) as a prototype of diseases caused by misfolded proteins and review recent findings about its pathobiology and the development of novel pharmacological strategies.
Journal ArticleDOI
Production of recombinant serpins in Escherichia coli
TL;DR: The general approaches and procedures to be considered when contemplating the use of E. coli for recombinant serpin production are outlined.