S
Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
Papers
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Journal ArticleDOI
Monolithic microfabricated valves and pumps by multilayer soft lithography
TL;DR: An extension to the soft lithography paradigm, multilayersoft lithography, with which devices consisting of multiple layers may be fabricated from soft materials is described, to build active microfluidic systems containing on-off valves, switching valves, and pumps entirely out of elastomer.
Journal ArticleDOI
Microfluidics: Fluid physics at the nanoliter scale
Todd M. Squires,Stephen R. Quake +1 more
TL;DR: A review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena as mentioned in this paper.
PatentDOI
Microfluidic large scale integration
TL;DR: The fluidic multiplexor as discussed by the authors is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs.
Journal ArticleDOI
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Maximilian Diehn,Robert W. Cho,Neethan A. Lobo,Tomer Kalisky,Mary Jo Dorie,Angela N. Kulp,Dalong Qian,Jessica Lam,Laurie Ailles,Manzhi Wong,Benzion Joshua,Michael J. Kaplan,Irene Wapnir,Frederick M. Dirbas,George Somlo,Carlos A. Garberoglio,Benjamin Paz,Jeannie Shen,Sean K. Lau,Stephen R. Quake,J. Martin Brown,Irving L. Weissman,Michael F. Clarke +22 more
TL;DR: It is shown that normal mammary epithelial stem cells contain lower concentrations of ROS than their more mature progeny cells, and subsets of CSCs in some tumours contain lower ROS levels and enhanced ROS defences compared to their non-tumorigenic progeny, which may contribute to tumour radioresistance.
Journal ArticleDOI
Dynamic pattern formation in a vesicle-generating microfluidic device.
TL;DR: It is shown that a microfluidic device designed to produce reverse micelles can generate complex, ordered patterns as it is continuously operated far from thermodynamic equilibrium.