Steven N. Goodman

TL;DR: Methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of the tumors to alkylating agents and an independent and stronger prognostic factor than age, stage, tumor grade, or performance status.

TL;DR: The default P-value threshold for statistical significance is proposed to be changed from 0.05 to 0.005 for claims of new discoveries in order to reduce uncertainty in the number of discoveries.

TL;DR: Misinterpretation and abuse of statistical tests, confidence intervals, and statistical power have been decried for decades, yet remain rampant as discussed by the authors, and there are no interpretations of these concepts that are at once simple, intuitive, correct, and foolproof Instead, correct use and interpretation of these statistics requires an attention to detail which seems to tax the patience of working scientists.

TL;DR: This article proposed to change the default P-value threshold for statistical significance for claims of new discoveries from 0.05 to 0.005, which is the threshold used in this paper.

TL;DR: This paper provided definitions and a discussion of basic statistics that are more general and critical than typically found in traditional introductory expositions, and provided an explanatory list of 25 misinterpretations of P values, confidence intervals, and power.