S
Svend Kjaer
Researcher at Francis Crick Institute
Publications - 77
Citations - 4737
Svend Kjaer is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Coronavirus. The author has an hindex of 26, co-authored 70 publications receiving 3574 citations. Previous affiliations of Svend Kjaer include Karolinska Institutet & London Research Institute.
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Journal ArticleDOI
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Ruth Harvey,Saira Hussain,Rachel Ulferts,Christopher Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Dhira Joshi,Nicola O’Reilly,Philip A. Walker,Svend Kjaer,Andrew Riddell,Catherine Moore,Bethany R. Jebson,Meredyth G. Ll Wilkinson,Lucy R. Marshall,Elizabeth C. Rosser,Anna Radziszewska,Hannah Peckham,Coziana Ciurtin,Lucy R. Wedderburn,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,John W. McCauley,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis,George Kassiotis +47 more
TL;DR: Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Helene Plun-Favreau,Kristina Klupsch,Nicoleta Moisoi,Sonia Gandhi,Svend Kjaer,David Frith,Kirsten Harvey,Emma Deas,Robert J. Harvey,Neil Q. McDonald,Nicholas W. Wood,L. Miguel Martins,Julian Downward +12 more
TL;DR: It is suggested that PINK1-dependent phosphorylation of HtrA2 might modulate its proteolytic activity, thereby contributing to an increased resistance of cells to mitochondrial stress.
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PINK1 cleavage at position A103 by the mitochondrial protease PARL
Emma Deas,Helene Plun-Favreau,Sonia Gandhi,Howard Desmond,Svend Kjaer,Samantha H. Y. Loh,Alan E. Renton,Robert J. Harvey,Alexander J. Whitworth,L. Miguel Martins,Andrey Y. Abramov,Nicholas W. Wood +11 more
TL;DR: It is suggested that PINK1 cleavage is important for basal mitochondrial health and that PARL cleaves Pink1 to produce the ΔN-PINK1 fragment, and that loss of PARL results in aberrant PINK 1 cleavage in mammalian cells.
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F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells
Susan Ahrens,Santiago Zelenay,David Sancho,Pavel Hanč,Svend Kjaer,Christoph Feest,Georgina C. Fletcher,Charlotte H. Durkin,Antonio Postigo,Mark Skehel,Facundo D. Batista,Barry J. Thompson,Michael Way,Caetano Reis e Sousa,Oliver Schulz +14 more
TL;DR: The identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity.
Journal ArticleDOI
Structure and Chemical Inhibition of the Ret Tyrosine Kinase Domain.
Phillip P. Knowles,Judith Murray-Rust,Svend Kjaer,Svend Kjaer,Rizaldy P. Scott,Sarah Hanrahan,Massimo Santoro,Carlos F. Ibáñez,Neil Q. McDonald,Neil Q. McDonald +9 more
TL;DR: The results suggest the existence of alternative inhibitory mechanisms, possibly in trans, for the autoregulation of RET kinase activity and explain why certain multiple endocrine neoplasia 2-associated RET mutants found in patients are resistant to inhibition and form the basis for design of more effective inhibitors.