T
Thanneer M. Perumal
Researcher at Sage Bionetworks
Publications - 42
Citations - 2886
Thanneer M. Perumal is an academic researcher from Sage Bionetworks. The author has contributed to research in topics: Expression quantitative trait loci & Gene. The author has an hindex of 16, co-authored 40 publications receiving 2005 citations. Previous affiliations of Thanneer M. Perumal include NanoString Technologies & University of Luxembourg.
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Journal ArticleDOI
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Menachem Fromer,Panos Roussos,Solveig K. Sieberts,Jessica S. Johnson,David H. Kavanagh,Thanneer M. Perumal,Douglas M. Ruderfer,Edwin C. Oh,Aaron Topol,Hardik Shah,Lambertus Klei,Robin Kramer,Dalila Pinto,Zeynep H. Gümüş,A. Ercument Cicek,Kristen K. Dang,Andrew W. Browne,Cong Lu,Lu Xie,Ben Readhead,Eli A. Stahl,Jianqiu Xiao,Mahsa Parvisi,Tymor Hamamsy,John F. Fullard,Ying-Chih Wang,Milind Mahajan,Jonathan M. J. Derry,Joel T. Dudley,Scott E. Hemby,Benjamin A. Logsdon,Konrad Talbot,Towfique Raj,Towfique Raj,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Jun Zhu,Bin Zhang,Patrick F. Sullivan,Patrick F. Sullivan,Andrew Chess,Shaun Purcell,Leslie A. Shinobu,Lara M. Mangravite,Hiroyoshi Toyoshiba,Raquel E. Gur,Chang-Gyu Hahn,David A. Lewis,Vahram Haroutunian,Mette A. Peters,Barbara K. Lipska,Joseph D. Buxbaum,Eric E. Schadt,Keisuke Hirai,Kathryn Roeder,Kristen J. Brennand,Nicholas Katsanis,Enrico Domenici,Bernie Devlin,Pamela Sklar +60 more
TL;DR: It is shown that schizophrenia is polygenic and the utility of this resource of gene expression and its genetic regulation for mechanistic interpretations of genetic liability for brain diseases is highlighted.
Journal ArticleDOI
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.
Solveig K. Sieberts,Thanneer M. Perumal,Minerva M. Carrasquillo,Mariet Allen,Joseph S. Reddy,Gabriel E. Hoffman,Kristen K. Dang,John N. Calley,Phillip J. Ebert,James A. Eddy,Xue Wang,Anna K. Greenwood,Sara Mostafavi,Sara Mostafavi,S Akbarian,J Bendl,M S Breen,K Brennand,L Brown,A Browne,J D Buxbaum,A Charney,Andrew Chess,Couto L,Gregory E. Crawford,Devillers O,Bernie Devlin,Amanda Dobbyn,E Domenici,M Filosi,E Flatow,Nancy Francoeur,John F. Fullard,S E Gil,Kiran Girdhar,A Gulyás-Kovács,R.E. Gur,C G Hahn,Vahram Haroutunian,Mads E. Hauberg,Laura M. Huckins,Rivka Jacobov,Y Jiang,Jessica S. Johnson,Bibi Kassim,Y Kim,Lambertus Klei,Robin Kramer,Mario Lauria,Thomas Lehner,David A. Lewis,Barbara K. Lipska,Kelsey S. Montgomery,R Park,C Rosenbluh,Panagiotis Roussos,Douglas M. Ruderfer,G Senthil,Hardik Shah,Laura G. Sloofman,L Song,E Stahl,P.F. Sullivan,R Visintainer,J Wang,Y C Wang,Jennifer Wiseman,E Xia,W Zhang,Elizabeth Zharovsky,L Addis,S N Addo,David C. Airey,Matthias Arnold,David A. Bennett,Y Bi,K Biber,Colette Blach,E Bradhsaw,Paul Brennan,R Canet-Aviles,S Cao,A Cavalla,Yooree Chae,W W Chen,J Cheng,David A. Collier,J L Dage,Eric B. Dammer,J W Davis,John B. Davis,Derek Drake,D Duong,Brian J. Eastwood,Michelle E. Ehrlich,B Ellingson,B W Engelmann,S Esmaeelinieh,Daniel Felsky,Cory C. Funk,Chris Gaiteri +100 more
TL;DR: A colocalization analysis is applied to identify genes underlying the GWAS association peaks for schizophrenia and identify a potentially novel gene colocalized with lncRNA RP11-677M14.
Journal ArticleDOI
Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map
Kazuhiro Fujita,Marek Ostaszewski,Yukiko Matsuoka,Samik Ghosh,Enrico Glaab,Christophe Trefois,Isaac Crespo,Thanneer M. Perumal,Wiktor Jurkowski,Paul Antony,Nico J. Diederich,Nico J. Diederich,Manuel Buttini,Akihiko Kodama,Venkata P. Satagopam,Serge Eifes,Antonio del Sol,Reinhard Schneider,Hiroaki Kitano,Rudi Balling +19 more
TL;DR: A computationally tractable, comprehensive molecular interaction map of Parkinson's disease that integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation is introduced.
Journal ArticleDOI
Unsupervised analysis of transcriptomics in bacterial sepsis across multiple datasets reveals three robust clusters
Timothy E. Sweeney,Tej D. Azad,Michele Donato,Winston A. Haynes,Thanneer M. Perumal,Ricardo Henao,Jesus F. Bermejo-Martin,Raquel Almansa,Eduardo Tamayo,Judith A. Howrylak,Augustine M.K. Choi,Grant P Parnell,Benjamin Tang,Marshall Nichols,Christopher W. Woods,Christopher W. Woods,Geoffrey S. Ginsburg,Stephen F. Kingsmore,Larsson Omberg,Lara M. Mangravite,Hector R. Wong,Ephraim L. Tsalik,Ephraim L. Tsalik,Raymond J. Langley,Purvesh Khatri +24 more
TL;DR: A unified clustering analysis across 14 discovery datasets revealed three sepsis subtypes, which, based on functional analysis, were termed “Inflammopathic, Adaptive, and Coagulopathic,” which may represent a unifying framework for understanding the molecular heterogeneity of the sepsi syndrome.
Posted ContentDOI
Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia
Menachem Fromer,Panos Roussos,Solveig K. Sieberts,Jessica S. Johnson,David H. Kavanagh,Thanneer M. Perumal,Douglas M. Ruderfer,Edwin C. Oh,Aaron Topol,Hardik Shah,Lambertus Klei,Robin Kramer,Dalila Pinto,Zeynep H. Gümüş,A. Ercument Cicek,Kristen K. Dang,Andrew W. Browne,Cong Lu,Li Xie,Ben Readhead,Eli A. Stahl,Mahsa Parvisi,Tymor Hamamsy,John F. Fullard,Ying-Chih Wang,Milind Mahajan,Jonathan M. J. Derry,Joel T. Dudley,Scott E. Hemby,Benjamin A. Logsdon,Konrad Talbot,Towfique Raj,David A. Bennett,Philip L. De Jager,Jun Zhu,Bin Zhang,Patrick F. Sullivan,Andrew Chess,Shaun Purcell,Leslie A. Shinobu,Lara M. Mangravite,Hiroyoshi Toyoshiba,Raquel E. Gur,Chang-Gyu Hahn,David A. Lewis,Vahram Haroutonian,Mette A. Peters,Barbara K. Lipska,Joseph D. Buxbaum,Eric E. Schadt,Keisuke Hirai,Kathryn Roeder,Kristen J. Brennand,Nicholas Katsanis,Enrico Domenici,Bernie Devlin,Pamela Sklar +56 more
TL;DR: Co-expression analyses identify a gene module that shows enrichment for genetic associations and is thus relevant for schizophrenia, paving the way for mechanistic interpretations of genetic liability for schizophrenia and other brain diseases.