T
Thomas Fröhlich
Researcher at Ludwig Maximilian University of Munich
Publications - 140
Citations - 5294
Thomas Fröhlich is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Proteome & Medicine. The author has an hindex of 34, co-authored 120 publications receiving 4089 citations. Previous affiliations of Thomas Fröhlich include Center for Integrated Protein Science Munich.
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Journal ArticleDOI
The ecoresponsive genome of Daphnia pulex
John K. Colbourne,Michael E. Pfrender,Michael E. Pfrender,Donald L. Gilbert,W. Kelley Thomas,Abraham E. Tucker,Abraham E. Tucker,Todd H. Oakley,Shin-ichi Tokishita,Andrea Aerts,Georg J. Arnold,Malay Kumar Basu,Malay Kumar Basu,Darren J Bauer,Carla E. Cáceres,Liran Carmel,Liran Carmel,Claudio Casola,Jeong Hyeon Choi,John C. Detter,Qunfeng Dong,Qunfeng Dong,Serge Dusheyko,Brian D. Eads,Thomas Fröhlich,Kerry Geiler-Samerotte,Kerry Geiler-Samerotte,Daniel Gerlach,Daniel Gerlach,Phil Hatcher,Sanjuro Jogdeo,Sanjuro Jogdeo,Jeroen Krijgsveld,Evgenia V. Kriventseva,Dietmar Kültz,Christian Laforsch,Erika Lindquist,Jacqueline Lopez,J. Robert Manak,J. Robert Manak,Jean Muller,Jasmyn Pangilinan,Rupali P Patwardhan,Rupali P Patwardhan,Samuel Pitluck,Ellen J. Pritham,Andreas Rechtsteiner,Andreas Rechtsteiner,Mina Rho,Igor B. Rogozin,Onur Sakarya,Onur Sakarya,Asaf Salamov,Sarah Schaack,Sarah Schaack,Harris Shapiro,Yasuhiro Shiga,Courtney Skalitzky,Zachary Smith,Alexander Souvorov,Way Sung,Zuojian Tang,Zuojian Tang,Dai Tsuchiya,Hank Tu,Hank Tu,Harmjan R. Vos,Mei Wang,Yuri I. Wolf,Hideo Yamagata,Takuji Yamada,Yuzhen Ye,Joseph R. Shaw,Justen Andrews,Teresa J. Crease,Haixu Tang,Susan Lucas,Hugh M. Robertson,Peer Bork,Eugene V. Koonin,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Igor V. Grigoriev,Michael Lynch,Jeffrey L. Boore,Jeffrey L. Boore +85 more
TL;DR: The Daphnia genome reveals a multitude of genes and shows adaptation through gene family expansions, and the coexpansion of gene families interacting within metabolic pathways suggests that the maintenance of duplicated genes is not random.
Journal ArticleDOI
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Jan Hendrik Straub,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +17 more
TL;DR: Structural characterization of the inhibitory mechanism of Nsp1 may aid structure-based drug design against SARS-CoV-2 and effectively blocks retinoic acid–inducible gene I–dependent innate immune responses that would otherwise facilitate clearance of the infection.
Posted ContentDOI
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +16 more
TL;DR: It is shown that Nsp1 from SARS-CoV-2 binds to 40S and 80S ribosomes, resulting in shutdown of capped mRNA translation both in vitro and in cells, which effectively blocks RIG-I-dependent innate immune responses that would otherwise facilitate clearance of the infection.
Journal ArticleDOI
Embryo-Maternal Communication in Bovine – Strategies for Deciphering a Complex Cross-Talk
Eckhard Wolf,Guy Arnold,Stefan Bauersachs,Henning M. Beier,Helmut Blum,Ralf Einspanier,Thomas Fröhlich,A. Herrler,Stefan Hiendleder,Sabine Kölle,Katja Prelle,H.-D. Reichenbach,Miodrag Stojkovic,Hendrik Wenigerkind,Fred Sinowatz +14 more
TL;DR: State-of-the-art transcriptomic and proteomic technologies will identify reciprocal signals between embryos and their maternal environment and the respective downstream reaction cascades, and signalling mechanisms identified in bovine will also be functionally evaluated in other species, including the human.
Journal ArticleDOI
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
Alessandra Moretti,LM Fonteyne,Florian Giesert,Petra Hoppmann,A. B. Meier,Tarik Bozoglu,Andrea Baehr,Christine M. Schneider,Daniel Sinnecker,Katharina Klett,Thomas Fröhlich,F. Abdel Rahman,T. Haufe,Shicheng Sun,Victoria Jurisch,Barbara Kessler,Rabea Hinkel,Ralf J. Dirschinger,Eimo Martens,C. Jilek,Alexander Graf,Stefan Krebs,Gianluca Santamaria,Mayuko Kurome,V. Zakhartchenko,B. Campbell,K. Voelse,Anja Wolf,Tilman Ziegler,S. Reichert,Seungmin Lee,Florian Flenkenthaler,Tatjana Dorn,Irmela Jeremias,Helmut Blum,Andreas Dendorfer,Angelika Schnieke,S Krause,M. C. Walter,Nikolai Klymiuk,Karl-Ludwig Laugwitz,Eckhard Wolf,Wolfgang Wurst,Wolfgang Wurst,Christian Kupatt +44 more
TL;DR: CRISPR–Cas9-mediated gene editing restores dystrophin expression in both pig and human induced pluripotent stem cell models of Duchenne muscular dystrophy, with beneficial effects on skeletal muscle and cardiac function.