Tiia Ngandu

TL;DR: In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-of-concept randomised controlled trial, the authors aimed to assess a multidomain approach to prevent cognitive decline in at-risk elderly people from the general population.

TL;DR: Obesity at midlife is associated with an increased risk of dementia and AD later in life and the role of weight reduction for the prevention of dementia needs to be further investigated.

TL;DR: The dementia risk score is a novel approach for the prediction of dementia risk, but should be validated and further improved to increase its predictive value.

TL;DR: In this article, a review of the current knowledge of lifestyle-related risk factors and results from novel trials aiming to prevent cognitive decline and dementia is presented, including the World Wide FINGERS network, which aims to harmonize studies on dementia prevention, generate high-quality scientific evidence and promote its implementation.

TL;DR: This paper performed a two-stage genome-wide association study with 111,326 clinically diagnosed/proxy AD cases and 677,663 controls and found 75 risk loci, of which 42 were new at the time of analysis.