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Urban Lendahl
Researcher at Karolinska Institutet
Publications - 242
Citations - 31645
Urban Lendahl is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Notch signaling pathway & Nestin. The author has an hindex of 79, co-authored 228 publications receiving 28639 citations. Previous affiliations of Urban Lendahl include University of Hong Kong & Åbo Akademi University.
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Journal ArticleDOI
CNS stem cells express a new class of intermediate filament protein.
TL;DR: The predicted amino acid sequence of the nestin gene product shows that nestin defines a distinct sixth class of intermediate filament protein, extending a model in which transitions in intermediate filament gene expression reflect major steps in the pathway of neural differentiation.
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Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
TL;DR: Evidence is presented that ependymal cells are neural stem cells and a novel process in the response to central nervous system injury is identified, identified in response to spinal cord injury.
Journal ArticleDOI
Notch signalling controls pancreatic cell differentiation
Åsa Apelqvist,Hao Li,Lukas Sommer,Paul Beatus,David J. Anderson,Tasuku Honjo,Martin Hrabě de Angelis,Urban Lendahl,Helena Edlund +8 more
TL;DR: Evidence is provided that ngn3 acts as pro-endocrine gene and that Notch signalling is critical for the decision between theendocrine and progenitor/exocrine fates in the developing pancreas.
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A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.
Journal ArticleDOI
Generalized potential of adult neural stem cells.
Diana Clarke,Clas B. Johansson,Johannes Wilbertz,Biborka Veress,Erik Nilsson,Helena Karlström,Urban Lendahl,Jonas Frisén +7 more
TL;DR: It is shown that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers, demonstrating that an adult neural stem cell has a very broad developmental capacity.