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William E. Kraus
Researcher at Duke University
Publications - 625
Citations - 40583
William E. Kraus is an academic researcher from Duke University. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 93, co-authored 565 publications receiving 33692 citations. Previous affiliations of William E. Kraus include University of Texas Southwestern Medical Center & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
Ron Do,Ron Do,Nathan O. Stitziel,Hong-Hee Won,Hong-Hee Won,Anders Berg Jørgensen,Stefano Duga,Pier Angelica Merlini,Adam Kiezun,Martin Farrall,Anuj Goel,Or Zuk,Illaria Guella,Rosanna Asselta,Leslie A. Lange,Gina M. Peloso,Gina M. Peloso,Paul L. Auer,Domenico Girelli,Nicola Martinelli,Deborah N. Farlow,Mark A. DePristo,Robert Roberts,Alex Stewart,Danish Saleheen,John Danesh,Stephen E. Epstein,Suthesh Sivapalaratnam,G. Kees Hovingh,John J.P. Kastelein,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann,Svati H. Shah,William E. Kraus,Robert W. Davies,Majid Nikpay,Christopher T. Johansen,Jian Wang,Robert A. Hegele,Eliana Hechter,Winfried März,Winfried März,Winfried März,Marcus E. Kleber,Jie Huang,Andrew D. Johnson,Mingyao Li,Greg L. Burke,Myron D. Gross,Yongmei Liu,Themistocles L. Assimes,Gerardo Heiss,Ethan M. Lange,Aaron R. Folsom,Herman A. Taylor,Oliviero Olivieri,Anders Hamsten,Robert Clarke,Dermot F. Reilly,Wu Yin,Manuel A. Rivas,Peter Donnelly,Jacques E. Rossouw,Bruce M. Psaty,Bruce M. Psaty,David M. Herrington,James G. Wilson,Stephen S. Rich,Michael J. Bamshad,Russell P. Tracy,L. Adrienne Cupples,Daniel J. Rader,Muredach P. Reilly,John A. Spertus,Sharon Cresci,Jaana Hartiala,W.H. Wilson Tang,Stanley L. Hazen,Hooman Allayee,Alexander P. Reiner,Alexander P. Reiner,Christopher S. Carlson,Charles Kooperberg,Rebecca D. Jackson,Eric Boerwinkle,Eric S. Lander,Stephen M. Schwartz,Stephen M. Schwartz,David S. Siscovick,Ruth McPherson,Anne Tybjærg-Hansen,Gonçalo R. Abecasis,Hugh Watkins,Deborah A. Nickerson,Diego Ardissino,Shamil R. Sunyaev,Shamil R. Sunyaev,Christopher J. O'Donnell,David Altshuler,David Altshuler,Stacey Gabriel,Sekar Kathiresan,Sekar Kathiresan +103 more
TL;DR: Kathiresan et al. as mentioned in this paper used exome sequencing of nearly 10,000 people to identify alleles associated with early-onset myocardial infarction; mutations in low-density lipoprotein receptor (LDLR) or apolipoprotein A-V (APOA5) were associated with disease risk.
Journal ArticleDOI
Population Approaches to Improve Diet, Physical Activity, and Smoking Habits: A Scientific Statement From the American Heart Association
Dariush Mozaffarian,Ashkan Afshin,Neal L. Benowitz,Vera Bittner,Stephen R. Daniels,Harold A. Franch,David R. Jacobs,William E. Kraus,Penny M. Kris-Etherton,Debra A. Krummel,Barry M. Popkin,Laurie P. Whitsel,Neil A. Zakai +12 more
TL;DR: In this article, the authors systematically reviewed and graded the current scientific evidence for effective population approaches to improve dietary habits, increase physical activity, and reduce tobacco use, including media and educational campaigns, labeling and consumer information, taxation, subsidies, and other economic incentives.
Journal ArticleDOI
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
Deborah M. Muoio,Paul S. MacLean,David B. Lang,Shi Li,Joseph A. Houmard,James M. Way,Deborah A. Winegar,J. Christopher Corton,G. Lynis Dohm,William E. Kraus +9 more
TL;DR: Results show redundancy in the functions of PPars α and δ as transcriptional regulators of fatty acid homeostasis and suggest that in skeletal muscle high levels of the δ-subtype can compensate for deficiency of PPARα.
Journal ArticleDOI
Association of a Peripheral Blood Metabolic Profile with Coronary Artery Disease and Risk of Subsequent Cardiovascular Events
Svati H. Shah,James R. Bain,Michael J. Muehlbauer,Robert Stevens,David R. Crosslin,Carol Haynes,Jennifer R. Dungan,L. Kristin Newby,Elizabeth R. Hauser,Geoffrey S. Ginsburg,Christopher B. Newgard,William E. Kraus +11 more
TL;DR: Metabolite profiles are associated with CAD and subsequent cardiovascular events and were associated with cardiovascular events in the event-replication group.
Journal ArticleDOI
Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women
Kim M. Huffman,Svati H. Shah,Robert Stevens,James R. Bain,Michael J. Muehlbauer,Cris A. Slentz,Charles J. Tanner,Maragatha Kuchibhatla,Joseph A. Houmard,Christopher B. Newgard,William E. Kraus +10 more
TL;DR: Elevated concentrations of large, neutral amino acids were independently associated with insulin resistance and fatty acids were inversely related to the pancreatic response to glucose, suggesting that these metabolic intermediates might play a role in the progression to type 2 diabetes.