Y
Yew Kok Lee
Researcher at Agency for Science, Technology and Research
Publications - 13
Citations - 2758
Yew Kok Lee is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Gene & Chromatin immunoprecipitation. The author has an hindex of 9, co-authored 13 publications receiving 2517 citations. Previous affiliations of Yew Kok Lee include Genome Institute of Singapore.
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Journal ArticleDOI
An oestrogen-receptor-α-bound human chromatin interactome
Melissa J. Fullwood,Mei Hui Liu,You Fu Pan,Jun Liu,Han Xu,Yusoff Bin Mohamed,Yuriy L. Orlov,Stoyan Velkov,Andrea Ho,Poh Huay Mei,Elaine G.Y. Chew,Phillips Yao Hui Huang,Willem Welboren,Yuyuan Han,Hong Sain Ooi,Pramila N. Ariyaratne,Vinsensius B. Vega,Yanquan Luo,Peck Yean Tan,Pei Ye Choy,K. D. Senali Abayratna Wansa,Bing Zhao,Kar Sian Lim,Shi Chi Leow,Jit Sin Yow,Roy Joseph,Haixia Li,Kartiki V. Desai,Jane S. Thomsen,Yew Kok Lee,R. Krishna Murthy Karuturi,Thoreau Herve,Guillaume Bourque,Hendrik G. Stunnenberg,Xiaoan Ruan,Valere Cacheux-Rataboul,Wing-Kin Sung,Wing-Kin Sung,Edison T. Liu,Chia-Lin Wei,Edwin Cheung,Edwin Cheung,Edwin Cheung,Yijun Ruan,Yijun Ruan +44 more
TL;DR: It is proposed that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes and is described as a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global Chromatin interactions.
Journal ArticleDOI
Whole-Genome Cartography of Estrogen Receptor α Binding Sites
Chin-Yo Lin,Vinsensius B. Vega,Jane S. Thomsen,Tao Zhang,Say Li Li Kong,Ming Xie,Kuo-Ping Ping Chiu,Leonard Lipovich,Daniel H. Barnett,Fabio Stossi,Ailing Yeo,Joshy George,Vladimir A. Kuznetsov,Yew Kok Lee,Tze Howe Charn,Nallasivam Palanisamy,Lance D. Miller,Edwin Cheung,Edwin Cheung,Benita S. Katzenellenbogen,Yijun Ruan,Guillaume Bourque,Chia-Lin Wei,Edison T. Liu +23 more
TL;DR: It is found that only 22%–24% of the bona fide human ERα binding sites were overlapping conserved regions in whole genome vertebrate alignments, which suggest limited conservation of functional binding sites.
Journal ArticleDOI
Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition
Runrui Zhang,Qingyan Cui,Kiyohito Murai,Yen Ching Lim,Zachary D. Smith,Zachary D. Smith,Shengnan Jin,Peng Ye,Luis Rosa,Yew Kok Lee,Hai-Ping Wu,Wei Liu,Zhi-Mei Xu,Lu Yang,Yu-Qiang Ding,Yu-Qiang Ding,Fuchou Tang,Alexander Meissner,Alexander Meissner,Chunming Ding,Yanhong Shi,Guoliang Xu +21 more
TL;DR: It is demonstrated that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain, and that it is positively involved in the epigenetic regulation of neural progensitor cells proliferation in the adult brain.
Journal ArticleDOI
Genome-Wide Dynamics of Chromatin Binding of Estrogen Receptors α and β: Mutual Restriction and Competitive Site Selection
Tze Howe Charn,Edison T. Liu,Edmund C. Chang,Yew Kok Lee,John A. Katzenellenbogen,John A. Katzenellenbogen,Benita S. Katzenellenbogen +6 more
TL;DR: The dynamic interplay between these two receptors in their selection of chromatin binding sites when present separately or together in MCF-7 breast cancer cells is explored, with competition, restriction, and site shifting having important implications for the regulation of gene expression by these two nuclear receptors.
Journal ArticleDOI
Global DNA Hypermethylation in Down Syndrome Placenta
Shengnan Jin,Yew Kok Lee,Yen Ching Lim,Zejun Zheng,Xueqin Michelle Lin,Desmond P. Y. Ng,Joanna D. Holbrook,Hai-Yang Law,Kenneth Kwek,George S. H. Yeo,Chunming Ding +10 more
TL;DR: DNA methylation perturbation was conserved in DS placenta villi and in adult DS peripheral blood leukocytes, and enriched for genes known to be causally associated with DS phenotypes, suggesting that global epigenetic changes may occur early in development and contribute toDS phenotypes.