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Xiaoyong Zhi
Researcher at Van Andel Institute
Publications - 9
Citations - 972
Xiaoyong Zhi is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Autophagy & Repressor. The author has an hindex of 8, co-authored 9 publications receiving 842 citations. Previous affiliations of Xiaoyong Zhi include Nanjing University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Autophagy in cancer
Xiaoyong Zhi,Qing Zhong +1 more
TL;DR: Recent progress on the role of autophagy in tumorigenesis and cancer therapy is summarized.
Journal ArticleDOI
ATG14 controls SNARE-mediated autophagosome fusion with a lysosome.
Rong Liu,Xiaoyong Zhi,Qing Zhong +2 more
TL;DR: It is demonstrated that fusogenic activity of the autophagic SNARE complex is temporally and spatially controlled by ATG14/Barkor/Atg14L, an essential autophagy-specific regulator of the class III phosphatidylinositol 3-kinase complex (PtdIns3K).
Journal ArticleDOI
Anatomy of autophagy: from the beginning to the end
TL;DR: The hallmark events involved in autophagy, from its initiation, to the final destruction of engulfed targets are described and rationale as to how they control autophagic events in a highly ordered manner is provided.
Journal ArticleDOI
Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes
Xiaoyong Zhi,X. Edward Zhou,Karsten Melcher,Daniel L. Motola,Verena Gelmedin,John M. Hawdon,Steven A. Kliewer,David J. Mangelsdorf,H. Eric Xu,H. Eric Xu +9 more
TL;DR: Results reveal the molecular mechanism for the interplay between parasite and host, provide a structural framework for DAF-12 as a promising target in treating nematode parasitism, and provide insight into the evolution of gut parasite hormone-signaling pathways.