Yuri Shimizu

TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.

TL;DR: Zhang et al. as mentioned in this paper demonstrate that RUNX1 contributes DNA demethylation in a binding site-directed manner in human hematopoietic cells. But the role of the epigenetic role of runx1 remains unclear.

TL;DR: A screening system that involves the ectopic expression of target TFs in model cells followed by DNA methylome analysis and overrepresentation analysis of the corresponding TF binding motif at differentially methylated regions successfully identified binding site-directed demethylation of SPI1.

TL;DR: Evidence is provided that RUNX1 contributes site specificity of DNA dem methylation by recruitment of TET and other demethylation-related enzymes to its binding sites in hematopoietic cells.

TL;DR: It is found that the ectopic overexpression of RUNX1 in HEK-293T cells induces almost complete DNA demethylation at the −17-kb upstream regulatory region and partial but significant DNA demethylation at the proximal promoter region, suggesting active DNA dem methylation.