Bareilly College

About: Bareilly College is a based out in . It is known for research contribution in the topics: Quantitative structure–activity relationship & Population. The organization has 171 authors who have published 214 publications receiving 2127 citations.

Synthesis of some new 1, 3-di methyl substituted guanidine with possible antibacterial and antifungal activity

Abstract: The compounds containing thiazole, thiadiazole, oxazole, oxadiazole, imidazole, pyrimidine, pyridine & benzothiazole rings have been found to exhibit broad spectrum of biological activities. Derivatives of 1, 2, 4-thiadiazole and 1, 2, 4-thiadiazolidines exhibit antibacterial and antifungal activity 1 . Thiazolyl guanidines2 and various substituted aryl guanidine’s have been found to exhibit antibacterial & antifungal activities3.Keeping all these views in mind attempts were made to synthesized some new 1,3-di methyl Substituted Guanidine. In the present work 2,4 Dimethyl -3,5-(di Aryl imino)-1,2,4-thiadiazolidines were prepared by nitrous acid oxidation of N-methyl –N Aryl thiourea4 & 2,4 dimethyl-3,5-(diaryl imino)-1,2,4-thiazolidines were converted to corresponding 1,3 di methyl substituted guanidine’s by their acid catalyzed re-arrangment5.(Scheme-1) Antibacterial & Antifungal activity of the title compounds were evaluated against two bacteria, E.coli & lactobacillus & two fungi, A.Brassicicola & Aspergillus Niger. N=methyl-N`-Aryl thiourea (1-10) were prepared by refluxing a mixture of different 2-Amino Heterocyclic moieties with methyl iso thiocyanate in Ethanol. A mixture of compound (1-100 and conc. HCl, ethanol was added drop wise & under stirring to a solution of NaNO2 in water afforded 2, 4-dimethyl-3, 5-(di Aryl imino)-1,2,4-thiadiazolidine (11-20) afforded 1,3 di methyl substituted guanidine’s (21-30). Structures of the compounds were established by elemental analysis & spectral data.

Molecular mechanics and quantum chemistry study of cobalt-thiazolidinethione complexes

Abstract: Eigenvalue, eigenvector, and overlap matrix of the cobalt halide complex with thiazolidinethione have been estimated The theoretically estimated values of ligand field parameters such as Dq, B′, and β are very close to the experimental results Hence, the theoretical methods based on molecular mechanics calculation can be well relied upon The eigenvector analysis and population analysis have shown that in bonding only s-and d orbitals are involved both in halides (CoX2) and their complexes (CoX2 · 2L) The involvement of p orbitals is negligible The sd hybridization is accordingly supported On the basis of these results sd 3 hybridization is supported The bond angles, total energy, and ligand field parameters estimated theoretically indicate that thiazolidinethione is coordinated to cobalt through its thioamide sulfur

Serum iron level of the common Indian frogRana tigrina Daud.

Abstract: A study extending over a period of 2 years has been made on serum iron level of common Indian frogR. tigrina. Serum iron averages 99.4 μg/100 ml in female and 92.60 μg/100 ml in males. The serum iron concentration is relatively high from May to October. Starvation has been found to decrease the serum iron level from the 16th day onwards.

Improved estimation under midzuno – lahiri – sen type sampling scheme

Abstract: The generalized ratio type estimator for estimating the mean or total of finite population proposed by Walsh (1970) is reconsidered following Midzuno-Lahiri-Sen type sampling scheme. The unbiasedness of the generalized ratio estimator under the proposed Midzuno-Lahiri-Sen type sampling scheme is established and the expression of mean square error of the generalized ratio estimator under the proposed Midzuno-Lahiri-Sen type sampling scheme is derived. Further the optimum value of the parameter involved and the minimum mean square error under this optimum value of the parameter are also given. A comparative study of the proposed sampling strategy as compared to mean per unit estimator, ratio estimator, product estimator, linear regression estimator and generalized ratio estimator (Walsh) is made. The concluding remarks show that using suitable range information we can get estimators which under the proposed Midzuno-Lahiri-Sen type sampling scheme are better than the usual mean per unit estimator, ratio estimator, product estimator, linear regression estimator and generalized ratio estimator (Walsh) in the sense of unbiasedness and smaller mean square error. Finally an empirical study is included for illustration.