Institution
Chinese Academy of Sciences
Government•Beijing, Beijing, China•
About: Chinese Academy of Sciences is a government organization based out in Beijing, Beijing, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 421602 authors who have published 634849 publications receiving 14894293 citations. The organization is also known as: CAS.
Topics: Catalysis, Population, Laser, Adsorption, Graphene
Papers published on a yearly basis
Papers
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TL;DR: It is reported that the gradient structure in engineering materials such as metals renders a unique extra strain hardening, which leads to high ductility, which is a hitherto unknown strategy to develop strong and ductile materials by architecting heterogeneous nanostructures.
Abstract: Gradient structures have evolved over millions of years through natural selection and optimization in many biological systems such as bones and plant stems, where the structures change gradually from the surface to interior. The advantage of gradient structures is their maximization of physical and mechanical performance while minimizing material cost. Here we report that the gradient structure in engineering materials such as metals renders a unique extra strain hardening, which leads to high ductility. The grain-size gradient under uniaxial tension induces a macroscopic strain gradient and converts the applied uniaxial stress to multiaxial stresses due to the evolution of incompatible deformation along the gradient depth. Thereby the accumulation and interaction of dislocations are promoted, resulting in an extra strain hardening and an obvious strain hardening rate up-turn. Such extraordinary strain hardening, which is inherent to gradient structures and does not exist in homogeneous materials, provides a hitherto unknown strategy to develop strong and ductile materials by architecting heterogeneous nanostructures.
848 citations
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TL;DR: Results indicate a gender dependent feature of nanotoxicity andKidney, liver and spleen are found to be target organs of nano-copper particles.
845 citations
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844 citations
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TL;DR: A high-resolution ice core record from Dasuopu, Tibet, reveals that this site is sensitive to fluctuations in the intensity of the South Asian Monsoon, and suggests a large-scale, plateau-wide 20th-century warming trend that appears to be amplified at higher elevations.
Abstract: A high-resolution ice core record from Dasuopu, Tibet, reveals that this site is sensitive to fluctuations in the intensity of the South Asian Monsoon. Reductions in monsoonal intensity are recorded by dust and chloride concentrations. The deeper, older sections of the Dasuopu cores suggest many other periods of drought in this region, but none have been of greater intensity than the greatest recorded drought, during 1790 to 1796 A.D. of the last millennium. The 20th century increase in anthropogenic activity in India and Nepal, upwind from this site, is recorded by a doubling of chloride concentrations and a fourfold increase in dust. Like other ice cores from the Tibetan Plateau, Dasuopu suggests a large-scale, plateau-wide 20th-century warming trend that appears to be amplified at higher elevations.
843 citations
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TL;DR: This study suggests that tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple α-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.
Abstract: Two Krebs cycle genes, fumarate hydratase (FH )a ndsuccinate dehydrogenase (SDH), are mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate and succinate, respectively. Here we demonstrate that fumarate and succinate are competitive inhibitors of multiple a-ketoglutarate (a-KG)dependent dioxygenases, including histone demethylases, prolyl hydroxylases, collagen prolyl-4-hydroxylases, and the TET (ten-eleven translocation) family of 5-methlycytosine (5mC) hydroxylases. Knockdown of FH and SDH results in elevated intracellular levels of fumarate and succinate, respectively, which act as competitors of a-KG to broadly inhibit the activity of a-KG-dependent dioxygenases. In addition, ectopic expression of tumor-derived FH and SDH mutants inhibits histone demethylation and hydroxylation of 5mC. Our study suggests that tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple a-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation. These epigenetic alterations associated with mutations of FH and SDH likely contribute to tumorigenesis.
840 citations
Authors
Showing all 422053 results
Name | H-index | Papers | Citations |
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Frank B. Hu | 250 | 1675 | 253464 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Yi Chen | 217 | 4342 | 293080 |
Jing Wang | 184 | 4046 | 202769 |
Peidong Yang | 183 | 562 | 144351 |
Xiaohui Fan | 183 | 878 | 168522 |
H. S. Chen | 179 | 2401 | 178529 |
Douglas Scott | 178 | 1111 | 185229 |
Jie Zhang | 178 | 4857 | 221720 |
Pulickel M. Ajayan | 176 | 1223 | 136241 |
Feng Zhang | 172 | 1278 | 181865 |
Andrea Bocci | 172 | 2402 | 176461 |
Yang Yang | 171 | 2644 | 153049 |
Lei Jiang | 170 | 2244 | 135205 |
Yang Gao | 168 | 2047 | 146301 |