Durham University

About: Durham University is a education organization based out in Durham, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 39385 authors who have published 82311 publications receiving 3110994 citations. The organization is also known as: University of Durham & Gallery of Durham University.

Interventions for treating obesity in children

Abstract: Childhood obesity affects both the physical and psychosocial health of children and may put them at risk of ill health as adults. More information is needed about the best way to treat obesity in children and adolescents. In this review, 64 studies were examined including 54 studies on lifestyle treatments (with a focus on diet, physical activity or behaviour change) and 10 studies on drug treatment to help overweight and obese children and their families with weight control. No surgical treatment studies were suitable to include in this review. This review showed that lifestyle programs can reduce the level of overweight in child and adolescent obesity 6 and 12 months after the beginning of the program. In moderate to severely obese adolescents, a reduction in overweight was found when either the drug orlistat, or the drug sibutramine were given in addition to a lifestyle program, although a range of adverse effects was also noted. Information on the long-term outcome of obesity treatment in children and adolescents was limited and needs to be examined in some high quality studies.

Models of emotional intelligence

Abstract: COMPETING MODELS OF EMOTIONAL INTELLIGENCE Studies of emotional intelligence initially appeared in academic articles beginning in the early 1990s. By middecade, the concept had attracted considerable popular attention, and powerful claims were made concerning its importance for predicting success. Emotional intelligence is the set of abilities that accounts for how people's emotional reports vary in their accuracy and how the more accurate understanding of emotion leads to better problem solving in an individual's emotional life. More formally, we define emotional intelligence as the ability to perceive and express emotion, assimilate emotion in thought, understand and reason with emotion, and regulate emotion in the self and others (Mayer & Salovey, 1997). As of now, the academic concept has been developed over several theoretical articles (e.g., Mayer & Salovey, 1997; Salovey & Mayer, 1990) and is based on a growing body of relevant research (e.g., Averill & Nunley, 1992; Buck, 1984; Lane, Sechrest, Reidel et al., 1996; Mayer, DiPaolo, & Salovey, 1990; Mayer & Geher, 1996; Mayer & Stevens, 1994; Rosenthal, Hall, DiMatteo, Rogers, & Archer, 1979; Salovey, Mayer, Goldman, Turvey, & Palfai, 1995; see also, Salovey & Sluyter, 1997). Shortly after the academic work began, a popular book on the subject appeared (Goleman, 1995a). The book covered much of the literature reviewed in the aforementioned articles as well as considerable additional research on emotions and the brain, emotions and social behavior, and school-based programs designed to help children develop emotional and social skills.

The Traumatic Impact of Child Sexual Abuse: A Conceptualization

Abstract: A framework is proposed for a more systematic understanding of the effects of child sexual abuse. Four traumagenic dynamics--traumatic sexualization, betrayal, stigmatization, and powerlessness--are identified as the core of the psychological injury inflicted by abuse. These dynamics can be used to make assessments of victimized children and to anticipate problems to which these children may be vulnerable subsequently. Implications for research are also considered.

ER stress and the unfolded protein response.

Abstract: Conformational diseases are caused by mutations altering the folding pathway or final conformation of a protein. Many conformational diseases are caused by mutations in secretory proteins and reach from metabolic diseases, e.g. diabetes, to developmental and neurological diseases, e.g. Alzheimer's disease. Expression of mutant proteins disrupts protein folding in the endoplasmic reticulum (ER), causes ER stress, and activates a signaling network called the unfolded protein response (UPR). The UPR increases the biosynthetic capacity of the secretory pathway through upregulation of ER chaperone and foldase expression. In addition, the UPR decreases the biosynthetic burden of the secretory pathway by downregulating expression of genes encoding secreted proteins. Here we review our current understanding of how an unfolded protein signal is generated, sensed, transmitted across the ER membrane, and how downstream events in this stress response are regulated. We propose a model in which the activity of UPR signaling pathways reflects the biosynthetic activity of the ER. We summarize data that shows that this information is integrated into control of cellular events, which were previously not considered to be under control of ER signaling pathways, e.g. execution of differentiation and starvation programs.

The reversal of the star formation-density relation in the distant universe

Abstract: Aims We study the relationship between the local environment of galaxies and their star formation rate (SFR) in the Great Observatories Origins Deep Survey, GOODS, at z∼1 Methods We use ultradeep imaging at 24� m with the MIPS camera onboard Spitzer to determine the contribution of obscured light to the SFR of galaxies over the redshift range 08≤ z ≤12 Accurate galaxy densities are measured thanks to the large sample of ∼1200 spectroscopic redshifts with high (∼70 %) spectroscopic completeness Morphology and stellar masses are derived from deep HST-ACS imaging, supplemented by ground based imaging programs and photometry from the IRAC camera onboard Spitzer Results We show that the star formation‐density relation observed locally was reversed at z∼ 1: the average SFR of an individual galaxy increased with local galaxy density when the universe was less than half its present age Hierarchical galaxy for mation models (simulated lightcones from the Millennium model) predicted such a reversal to occur only at earlier epochs (z>2) and at a lower level We present a remarkable structure at z∼ 1016, containing X-ray traced galaxy concentrations, which will eventually merge into a Virgo-like cluster This structure illustrates how the ind ividual SFR of galaxies increases with density and shows that it is the∼1‐2 Mpc scale that affects most the star formation in galaxies at z∼ 1 The SFR of z∼ 1 galaxies is found to correlate with stellar mass suggesting that mass plays a role in the observed star formation‐density trend However the specific SFR ( =SFR/M⋆) decreases with stellar mass while it increases with galaxy density, which i mplies that the environment does directly affect the star formation activity of galaxies Major mergers do not appear to be the unique or even major cause for this effect since nearly half (46 %) of the luminous infrared galaxies (LIRGs) at z∼ 1 present the HST-ACS morphology of spirals, while only a third present a clear signature of major mergers The remaining galaxies are divided into compact (9 %) and irregular (14 %) galaxies Moreover, the specific SFR o f major mergers is only marginally stronger than that of spirals Conclusions These findings constrain the influence of the growth of large- scale structures on the star formation history of galaxies Reproducing the SFR‐density relation at z∼ 1 is a new challenge for models, requiring a correct balance between mass assembly through mergers and in-situ star formation at early epochs