Showing papers by "Durham University published in 2020"
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
3,302 citations
Queen Mary University of London1, Durham University2, University of Bristol3, Charité4, National Institutes of Health5, Liverpool School of Tropical Medicine6, University of Southampton7, University of Tasmania8, AstraZeneca9, University of Edinburgh10, Cardiff University11, Medical Research Council12, University of Florida13, University of Sydney14, Janssen Pharmaceutica15, University of Bern16
TL;DR: The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) have been updated and information reorganised to facilitate their use in practice to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.
Abstract: Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the “ARRIVE Essential 10,” which constitutes the minimum requirement, and the “Recommended Set,” which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.
1,796 citations
Stanford University1, New York University2, Duke University3, Boston University4, Saint Louis University5, Northwick Park Hospital6, Imperial College London7, Hospital Universitario La Paz8, Durham University9, NewYork–Presbyterian Hospital10, Albany Medical College11, St. Michael's Hospital12, Montreal Heart Institute13, Auckland City Hospital14, All India Institute of Medical Sciences15, University of British Columbia16, Cedars-Sinai Medical Center17, Harvard University18, Brigham and Women's Hospital19, Columbia University Medical Center20, Saint Francis University21, University of Missouri–Kansas City22, Government Medical College, Thiruvananthapuram23, Sri Jayadeva Institute of Cardiovascular Sciences and Research24, University of São Paulo25, Veterans Health Administration26, Emory University27, Mayo Clinic28, Semmelweis University29, Flinders Medical Centre30, Université Paris-Saclay31, Uppsala University Hospital32, Uppsala University33, Keio University34, National Institutes of Health35, Vanderbilt University36, East Carolina University37, Icahn School of Medicine at Mount Sinai38
TL;DR: Evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years is not found.
Abstract: Background Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical ther...
1,324 citations
TL;DR: The role that telehealth has played in transforming healthcare delivery during the 3 phases of the U.S. COVID-19 pandemic is described and how people, process, and technology work together to support a successful telehealth transformation is examined.
986 citations
Queen Mary University of London1, Durham University2, University of Bristol3, Charité4, National Institutes of Health5, Liverpool School of Tropical Medicine6, University of Southampton7, University of Tasmania8, AstraZeneca9, University of Edinburgh10, Cardiff University11, Medical Research Council12, University of Florida13, University of Sydney14, Janssen Pharmaceutica15, University of Bern16
TL;DR: The ARRIVE guidelines are revised to update them and facilitate their use in practice and this explanation and elaboration document was developed as part of the revision.
Abstract: Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting is vital to this process; it allows readers to assess the reliability of the findings and repeat or build upon the work of other researchers. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. Despite widespread endorsement by the scientific community, the impact of ARRIVE on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This explanation and elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2.0, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature. This document also covers advice and best practice in the design and conduct of animal studies to support researchers in improving standards from the start of the experimental design process through to publication.
961 citations
Romina Ahumada1, Carlos Allende Prieto2, Carlos Allende Prieto3, Andres Almeida4 +342 more•Institutions (94)
TL;DR: The most recent data release from the Sloan Digital Sky Surveys (SDSS-IV) is DR16 as mentioned in this paper, which is the fourth and penultimate from the fourth phase of the survey.
Abstract: This paper documents the sixteenth data release (DR16) from the Sloan Digital Sky Surveys; the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the southern hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey (TDSS) and new data from the SPectroscopic IDentification of ERosita Survey (SPIDERS) programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17).
803 citations
University of Virginia1, McGill University2, National Radio Astronomy Observatory3, Goddard Space Flight Center4, West Virginia University5, Lafayette College6, Hillsdale College7, Durham University8, University of East Anglia9, University of Maryland, College Park10, First Green Bank11, University of British Columbia12, University of Toronto13, Hungarian Academy of Sciences14, Swinburne University of Technology15, University of Wisconsin–Milwaukee16, Chinese Academy of Sciences17
TL;DR: In this article, the authors measured the mass of the MSP J0740+6620 to be ${\mathbf{2.14} + 2.09} + 0.10% credibility interval.
Abstract: Despite its importance to our understanding of physics at supranuclear densities, the equation of state (EoS) of matter deep within neutron stars remains poorly understood. Millisecond pulsars (MSPs) are among the most useful astrophysical objects in the Universe for testing fundamental physics, and place some of the most stringent constraints on this high-density EoS. Pulsar timing—the process of accounting for every rotation of a pulsar over long time periods—can precisely measure a wide variety of physical phenomena, including those that allow the measurement of the masses of the components of a pulsar binary system1. One of these, called relativistic Shapiro delay2, can yield precise masses for both an MSP and its companion; however, it is only easily observed in a small subset of high-precision, highly inclined (nearly edge-on) binary pulsar systems. By combining data from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) 12.5-yr data set with recent orbital-phase-specific observations using the Green Bank Telescope, we have measured the mass of the MSP J0740+6620 to be $${\mathbf{2}}{\mathbf{.14}}_{ - {\mathbf{0}}{\mathbf{.09}}}^{ + {\mathbf{0}}{\mathbf{.10}}}$$ M⊙ (68.3% credibility interval; the 95.4% credibility interval is $${\mathbf{2}}{\mathbf{.14}}_{ - {\mathbf{0}}{\mathbf{.18}}}^{ + {\mathbf{0}}{\mathbf{.20}}}$$ M⊙). It is highly likely to be the most massive neutron star yet observed, and serves as a strong constraint on the neutron star interior EoS. Cromartie et al. have probably found the most massive neutron star discovered so far by combining NANOGrav 12.5-yr data with radio data from the Green Bank Telescope. Millisecond pulsar J0740+6620 has a mass of 2.14 M⊙, ~0.1 M⊙ more massive than the previous record holder, and very close to the upper limit on neutron star masses from Laser Interferometer Gravitational-Wave Observatory measurements.
770 citations
Charles University in Prague1, Academy of Sciences of the Czech Republic2, Stellenbosch University3, Canterbury of New Zealand4, University of Tennessee5, University of Fribourg6, Zoological Society of London7, University College London8, Williams College9, Durham University10, University of Vienna11, South African National Parks12, International Union for Conservation of Nature and Natural Resources13, Free University of Berlin14, Leibniz Association15, Helmholtz Centre for Environmental Research - UFZ16, Martin Luther University of Halle-Wittenberg17, United States Forest Service18, Czech University of Life Sciences Prague19, University of Toronto20, University of Rhode Island21, University of Concepción22, University of Konstanz23, Taizhou University24, Spanish National Research Council25, University of Seville26, University of Pretoria27
TL;DR: Improved international cooperation is crucial to reduce the impacts of invasive alien species on biodiversity, ecosystem services, and human livelihoods, as synergies with other global changes are exacerbating current invasions and facilitating new ones, thereby escalating the extent and impacts of invaders.
Abstract: Biological invasions are a global consequence of an increasingly connected world and the rise in human population size The numbers of invasive alien species – the subset of alien species that spread widely in areas where they are not native, affecting the environment or human livelihoods – are increasing Synergies with other global changes are exacerbating current invasions and facilitating new ones, thereby escalating the extent and impacts of invaders Invasions have complex and often immense long‐term direct and indirect impacts In many cases, such impacts become apparent or problematic only when invaders are well established and have large ranges Invasive alien species break down biogeographic realms, affect native species richness and abundance, increase the risk of native species extinction, affect the genetic composition of native populations, change native animal behaviour, alter phylogenetic diversity across communities, and modify trophic networks Many invasive alien species also change ecosystem functioning and the delivery of ecosystem services by altering nutrient and contaminant cycling, hydrology, habitat structure, and disturbance regimes These biodiversity and ecosystem impacts are accelerating and will increase further in the future Scientific evidence has identified policy strategies to reduce future invasions, but these strategies are often insufficiently implemented For some nations, notably Australia and New Zealand, biosecurity has become a national priority There have been long‐term successes, such as eradication of rats and cats on increasingly large islands and biological control of weeds across continental areas However, in many countries, invasions receive little attention Improved international cooperation is crucial to reduce the impacts of invasive alien species on biodiversity, ecosystem services, and human livelihoods Countries can strengthen their biosecurity regulations to implement and enforce more effective management strategies that should also address other global changes that interact with invasions
677 citations
TL;DR: Among patients with high-risk heart failure, the incidence of death from cardiovascular causes or hospitalization for heart failure was lower among those who received vericiguat than among thoseWho received placebo.
Abstract: Background The effect of vericiguat, a novel oral soluble guanylate cyclase stimulator, in patients with heart failure and reduced ejection fraction who had recently been hospitalized or h...
657 citations
TL;DR: This work describes and validate a simple-to-apply method for assessing and reporting on saturation in the context of inductive thematic analyses and proposes a more flexible approach to reporting saturation.
Abstract: Data saturation is the most commonly employed concept for estimating sample sizes in qualitative research. Over the past 20 years, scholars using both empirical research and mathematical/statistical models have made significant contributions to the question: How many qualitative interviews are enough? This body of work has advanced the evidence base for sample size estimation in qualitative inquiry during the design phase of a study, prior to data collection, but it does not provide qualitative researchers with a simple and reliable way to determine the adequacy of sample sizes during and/or after data collection. Using the principle of saturation as a foundation, we describe and validate a simple-to-apply method for assessing and reporting on saturation in the context of inductive thematic analyses. Following a review of the empirical research on data saturation and sample size estimation in qualitative research, we propose an alternative way to evaluate saturation that overcomes the shortcomings and challenges associated with existing methods identified in our review. Our approach includes three primary elements in its calculation and assessment: Base Size, Run Length, and New Information Threshold. We additionally propose a more flexible approach to reporting saturation. To validate our method, we use a bootstrapping technique on three existing thematically coded qualitative datasets generated from in-depth interviews. Results from this analysis indicate the method we propose to assess and report on saturation is feasible and congruent with findings from earlier studies.
640 citations
National Institutes of Health1, Wellcome Trust Sanger Institute2, Rockefeller University3, University of California, Davis4, European Bioinformatics Institute5, Seoul National University6, Max Planck Society7, Durham University8, University of Massachusetts Amherst9, University of Adelaide10, University of Missouri11, East Carolina University12, University of Queensland13, Queen Mary University of London14, Wellington Management Company15, University of Arizona16, Natural History Museum17, Bangor University18, University of Konstanz19, Northeastern University20, Naturalis21, University of Graz22, Florida Museum of Natural History23, University of California, Santa Cruz24, Pacific Biosciences25, University of Maryland, College Park26, Harbin Institute of Technology27, University of Chicago28, Oregon Health & Science University29, Monash University Malaysia Campus30, University of Milan31, University of Copenhagen32, Pennsylvania State University33, University of Los Andes34, Agency for Science, Technology and Research35, Royal Ontario Museum36, Smithsonian Conservation Biology Institute37, University of East Anglia38, Pompeu Fabra University39, University College Dublin40, University of Illinois at Urbana–Champaign41, La Trobe University42, University of California, San Diego43, UPRRP College of Natural Sciences44, Dresden University of Technology45
TL;DR: The Vertebrate Genomes Project is embarked on, an effort to generate high-quality, complete reference genomes for all ~70,000 extant vertebrate species and help enable a new era of discovery across the life sciences.
Abstract: High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are only available for a few non-microbial species. To address this issue, the international Genome 10K (G10K) consortium has worked over a five-year period to evaluate and develop cost-effective methods for assembling the most accurate and complete reference genomes to date. Here we summarize these developments, introduce a set of quality standards, and present lessons learned from sequencing and assembling 16 species representing major vertebrate lineages (mammals, birds, reptiles, amphibians, teleost fishes and cartilaginous fishes). We confirm that long-read sequencing technologies are essential for maximizing genome quality and that unresolved complex repeats and haplotype heterozygosity are major sources of error in assemblies. Our new assemblies identify and correct substantial errors in some of the best historical reference genomes. Adopting these lessons, we have embarked on the Vertebrate Genomes Project (VGP), an effort to generate high-quality, complete reference genomes for all ~70,000 extant vertebrate species and help enable a new era of discovery across the life sciences.
Children's Hospital of Philadelphia1, Great Ormond Street Hospital2, McMaster University3, Boston Children's Hospital4, St Mary's Hospital5, University of Queensland6, University of Cape Town7, University of Liverpool8, Durham University9, South University10, French Institute of Health and Medical Research11, University of Cambridge12, University Hospital Southampton NHS Foundation Trust13, Nationwide Children's Hospital14, Erasmus University Medical Center15, All India Institute of Medical Sciences16, Radboud University Nijmegen17, Royal Children's Hospital18, Children's Hospital Los Angeles19, New York University20, Stony Brook University21, Apollo Hospitals22, Johns Hopkins University23, University of the West of England24, University of Iowa25, St. Jude Children's Research Hospital26, Cincinnati Children's Hospital Medical Center27, Seattle Children's28, University of British Columbia29, Centre national de la recherche scientifique30
TL;DR: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations.
Abstract: OBJECTIVES: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. DESIGN: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. METHODS: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, "in our practice" statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. RESULTS: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 52 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, "in our practice" statements were provided. In addition, 49 research priorities were identified. CONCLUSIONS: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research.
TL;DR: Brolucizumab was noninferior to aflibercept in visual function at Week 48, and >50% of broluczumab 6 mg-treated eyes were maintained on q12w dosing interval through Week 48 and Anatomic retinal fluid outcomes favored Brolucizuab over afl fibercept.
TL;DR: This review summarizes recent experimental, computational, and theoretical research efforts that have contributed to improving the understanding and ability to predict the interactions of ABL flow with wind turbines and wind farms.
Abstract: Wind energy, together with other renewable energy sources, are expected to grow substantially in the coming decades and play a key role in mitigating climate change and achieving energy sustainability. One of the main challenges in optimizing the design, operation, control, and grid integration of wind farms is the prediction of their performance, owing to the complex multiscale two-way interactions between wind farms and the turbulent atmospheric boundary layer (ABL). From a fluid mechanical perspective, these interactions are complicated by the high Reynolds number of the ABL flow, its inherent unsteadiness due to the diurnal cycle and synoptic-forcing variability, the ubiquitous nature of thermal effects, and the heterogeneity of the terrain. Particularly important is the effect of ABL turbulence on wind-turbine wake flows and their superposition, as they are responsible for considerable turbine power losses and fatigue loads in wind farms. These flow interactions affect, in turn, the structure of the ABL and the turbulent fluxes of momentum and scalars. This review summarizes recent experimental, computational, and theoretical research efforts that have contributed to improving our understanding and ability to predict the interactions of ABL flow with wind turbines and wind farms.
Katrina L. Grasby1, Neda Jahanshad2, Jodie N. Painter1, Lucía Colodro-Conde3 +356 more•Institutions (115)
TL;DR: Results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness and find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.
Abstract: The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
Goddard Space Flight Center1, Widener University2, West Virginia University3, Montana State University4, Cornell University5, Canadian Institute for Advanced Research6, Centre national de la recherche scientifique7, University of Orléans8, Franklin & Marshall College9, University of Virginia10, Lafayette College11, United States Naval Research Laboratory12, National Radio Astronomy Observatory13, Hillsdale College14, Durham University15, McGill University16, University of British Columbia17, University of Washington18, Carnegie Mellon University19, University of Illinois at Urbana–Champaign20, University of Wisconsin–Milwaukee21, Northwestern University22, Oregon State University23, Rochester Institute of Technology24, California Institute of Technology25, University of Toronto26, First Green Bank27, York University28, University of Connecticut29, Eötvös Loránd University30, Vanderbilt University31, University of Colorado Boulder32, Swinburne University of Technology33, Oberlin College34
TL;DR: In this article, the authors search for an isotropic stochastic GWB in the 12.5-yr pulsar-timing data set collected by the North American Nanohertz Observatory for Gravitational Waves.
Abstract: We search for an isotropic stochastic gravitational-wave background (GWB) in the 12.5 yr pulsar-timing data set collected by the North American Nanohertz Observatory for Gravitational Waves. Our analysis finds strong evidence of a stochastic process, modeled as a power law, with common amplitude and spectral slope across pulsars. Under our fiducial model, the Bayesian posterior of the amplitude for an f −2/3 power-law spectrum, expressed as the characteristic GW strain, has median 1.92 × 10−15 and 5%–95% quantiles of 1.37–2.67 × 10−15 at a reference frequency of the Bayes factor in favor of the common-spectrum process versus independent red-noise processes in each pulsar exceeds 10,000. However, we find no statistically significant evidence that this process has quadrupolar spatial correlations, which we would consider necessary to claim a GWB detection consistent with general relativity. We find that the process has neither monopolar nor dipolar correlations, which may arise from, for example, reference clock or solar system ephemeris systematics, respectively. The amplitude posterior has significant support above previously reported upper limits; we explain this in terms of the Bayesian priors assumed for intrinsic pulsar red noise. We examine potential implications for the supermassive black hole binary population under the hypothesis that the signal is indeed astrophysical in nature.
University of Wisconsin-Madison1, Washington University in St. Louis2, Columbia University3, Boston University4, Johns Hopkins University School of Medicine5, Durham University6, Imperial College London7, University of Chicago8, National Institutes of Health9, Benaroya Research Institute10, University of Washington11
TL;DR: Underlying respiratory allergy and experimental allergen exposure reduce the expression of the SARS-CoV-2 receptor, ACE2, which could lead to reduced COVID-19 susceptibility.
Abstract: Underlying respiratory allergy and experimental allergen exposure reduce the expression of the SARS-CoV-2 receptor, ACE2, which could lead to reduced COVID-19 susceptibility.
Louisiana State University1, University of Virginia2, University of Minnesota3, Fred Hutchinson Cancer Research Center4, University of Washington5, University of Texas MD Anderson Cancer Center6, University at Albany, SUNY7, University of Pennsylvania8, Durham University9, University of California, San Francisco10, Harvard University11, American Cancer Society12, Thomas Jefferson University13
TL;DR: The American Cancer Society recommends that individuals aged >65 years who have no history of cervical intraepithelial neoplasia grade 2 or more severe disease within the past 25 years, discontinue all cervical cancer screening (qualified recommendation).
Abstract: The American Cancer Society (ACS) recommends that individuals with a cervix initiate cervical cancer screening at age 25 years and undergo primary human papillomavirus (HPV) testing every 5 years through age 65 years (preferred); if primary HPV testing is not available, then individuals aged 25 to 65 years should be screened with cotesting (HPV testing in combination with cytology) every 5 years or cytology alone every 3 years (acceptable) (strong recommendation). The ACS recommends that individuals aged >65 years who have no history of cervical intraepithelial neoplasia grade 2 or more severe disease within the past 25 years, and who have documented adequate negative prior screening in the prior 10 years, discontinue all cervical cancer screening (qualified recommendation). These new screening recommendations differ in 4 important respects compared with the 2012 recommendations: 1) The preferred screening strategy is primary HPV testing every 5 years, with cotesting and cytology alone acceptable where access to US Food and Drug Administration-approved primary HPV testing is not yet available; 2) the recommended age to start screening is 25 years rather than 21 years; 3) primary HPV testing, as well as cotesting or cytology alone when primary testing is not available, is recommended starting at age 25 years rather than age 30 years; and 4) the guideline is transitional, ie, options for screening with cotesting or cytology alone are provided but should be phased out once full access to primary HPV testing for cervical cancer screening is available without barriers. Evidence related to other relevant issues was reviewed, and no changes were made to recommendations for screening intervals, age or criteria for screening cessation, screening based on vaccination status, or screening after hysterectomy. Follow-up for individuals who screen positive for HPV and/or cytology should be in accordance with the 2019 American Society for Colposcopy and Cervical Pathology risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors.
TL;DR: In this article, the authors of standalone papers and graduate students in the Entrepreneurship domain are encouraged to write contribution-focused systematic reviews e.g. by providing a concrete guideline.
Abstract: Systematic literature reviews are an increasingly used review methodology to synthesize the existing body of literature in a field. However, editors complain about a high number of desk rejections because of a lack in quality. Poorly developed review articles are not published because of a perceived lack of contribution to the field. Our article supports authors of standalone papers and graduate students in the Entrepreneurship domain to write contribution-focused systematic reviews e.g. by providing a concrete guideline. Our article analyzes the strengths and weaknesses of a systematic literature review and how they can be overcome. Furthermore, we provide a combined list of highly ranked journals in the Entrepreneurship domain as a basis for quality appraisal. Finally, this article builds a scenario for the future of the systematic literature review methodology and shows how technological improvements have changed this methodology and what can be achieved in the future.
26 Jun 2020
TL;DR: It was found that women were somewhat more likely to engage in these health behaviors than men, but that age was generally unrelated to voluntary compliance behaviors and may suggest avenues and dead ends for behavioral interventions during COVID-19 and beyond.
Abstract: With a large international sample (n = 8317), the present study examined which beliefs and attitudes about COVID-19 predict 1) following government recommendations, 2) taking health precautions (including mask wearing, social distancing, handwashing, and staying at home), and 3) encouraging others to take health precautions The results demonstrate the importance of believing that taking health precautions will be effective for avoiding COVID-19 and generally prioritizing one’s health These beliefs continued to be important predictors of health behaviors after controlling for demographic and personality variables In contrast, we found that perceiving oneself as vulnerable to COVID-19, the perceived severity of catching COVID-19, and trust in government were of relatively little importance We also found that women were somewhat more likely to engage in these health behaviors than men, but that age was generally unrelated to voluntary compliance behaviors These findings may suggest avenues and dead ends for behavioral interventions during COVID-19 and beyond Highlights •Examines which beliefs and attitudes about COVID-19 predict 1) following government recommendations, 2) taking health precautions (including mask wearing, social distancing, handwashing, and staying at home), and 3) encouraging others to take health precautions•Uses a large international sample (n = 8317) to demonstrate the importance of believing that taking health precautions will be effective for avoiding COVID-19 and generally prioritizing one’s health•Finds that perceiving oneself as vulnerable to COVID-19, the perceived severity of catching COVID-19, and trust in government were of relatively little importance•Finds that women were somewhat more likely to engage in these health behaviors than men, but that age was generally unrelated to voluntary compliance behaviors
TL;DR: It is demonstrated that thermohaline-driven currents can control the distribution of microplastics by creating hotspots of accumulation, analogous to their role in causing focused areas of seafloor sediment deposition.
Abstract: Although microplastics are known to pervade the global seafloor, the processes that control their dispersal and concentration in the deep sea remain largely unknown. Here, we show that thermohaline-driven currents, which build extensive seafloor sediment accumulations, can control the distribution of microplastics and create hotspots with the highest concentrations reported for any seafloor setting (190 pieces per 50 grams). Previous studies propose that microplastics are transported to the seafloor by vertical settling from surface accumulations; here, we demonstrate that the spatial distribution and ultimate fate of microplastics are strongly controlled by near-bed thermohaline currents (bottom currents). These currents are known to supply oxygen and nutrients to deep-sea benthos, suggesting that deep-sea biodiversity hotspots are also likely to be microplastic hotspots.
Children's Hospital of Philadelphia1, Great Ormond Street Hospital2, McMaster University3, Boston Children's Hospital4, St Mary's Hospital5, University of Queensland6, University of Cape Town7, University of Liverpool8, Durham University9, French Institute of Health and Medical Research10, South University11, University of Cambridge12, University Hospital Southampton NHS Foundation Trust13, Nationwide Children's Hospital14, Erasmus University Medical Center15, All India Institute of Medical Sciences16, Radboud University Nijmegen17, Royal Children's Hospital18, University Health System19, Children's Hospital Los Angeles20, New York University21, Stony Brook University22, Apollo Hospitals23, Johns Hopkins University24, University of the West of England25, University of Iowa26, St. Jude Children's Research Hospital27, Cincinnati Children's Hospital Medical Center28, Seattle Children's29, University of British Columbia30, Centre national de la recherche scientifique31
TL;DR: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations.
Abstract: OBJECTIVES: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. DESIGN: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. METHODS: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, "in our practice" statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. RESULTS: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 49 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, "in our practice" statements were provided. In addition, 52 research priorities were identified. CONCLUSIONS: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research.
TL;DR: It is shown how scientifically derived colour maps report true data variations, reduce complexity, and are accessible for people with colour-vision deficiencies, in a simple guide for the scientific use of colour.
Abstract: The accurate representation of data is essential in science communication. However, colour maps that visually distort data through uneven colour gradients or are unreadable to those with colour-vision deficiency remain prevalent in science. These include, but are not limited to, rainbow-like and red-green colour maps. Here, we present a simple guide for the scientific use of colour. We show how scientifically derived colour maps report true data variations, reduce complexity, and are accessible for people with colour-vision deficiencies. We highlight ways for the scientific community to identify and prevent the misuse of colour in science, and call for a proactive step away from colour misuse among the community, publishers, and the press.
TL;DR: In this paper, a comprehensive theory of the through-space conjugation (TSC) for these chromophores is proposed, and various applications have been envisioned, for example in the areas of process monitoring, structural visualization, sensors, and probes.
TL;DR: Two soluble ectodomain constructs are developed for the SARS-CoV-2 S-protein, in which the highly immunogenic and mobile receptor binding domain (RBD) is either locked in the all-RBDs ‘down’ position or adopts ‘up’ state conformations more readily than the wild-type S- protein.
Abstract: The coronavirus (CoV) spike (S) protein, involved in viral-host cell fusion, is the primary immunogenic target for virus neutralization and the current focus of many vaccine design efforts. The highly flexible S-protein, with its mobile domains, presents a moving target to the immune system. Here, to better understand S-protein mobility, we implemented a structure-based vector analysis of available β-CoV S-protein structures. Despite an overall similarity in domain organization, we found that S-proteins from different β-CoVs display distinct configurations. Based on this analysis, we developed two soluble ectodomain constructs for the SARS-CoV-2 S-protein, in which the highly immunogenic and mobile receptor binding domain (RBD) is either locked in the all-RBDs 'down' position or adopts 'up' state conformations more readily than the wild-type S-protein. These results demonstrate that the conformation of the S-protein can be controlled via rational design and can provide a framework for the development of engineered CoV S-proteins for vaccine applications.
University of Maryland, College Park1, University of New Hampshire2, Potsdam Institute for Climate Impact Research3, Joint Global Change Research Institute4, Netherlands Environmental Assessment Agency5, Durham University6, National Institute for Environmental Studies7, International Institute for Applied Systems Analysis8, University of Bern9, Max Planck Society10, University of Hong Kong11, National Center for Atmospheric Research12, University of Copenhagen13, Ludwig Maximilian University of Munich14, Goddard Space Flight Center15, Princeton University16, Oak Ridge National Laboratory17, Food and Agriculture Organization18, University of Maryland Center for Environmental Science19
TL;DR: The Land-Use Harmonization 2 (LUH2) project is presented, which smoothly connects updated historical reconstructions of land use with eight new future projections in the format required for ESMs to enable new and improved estimates of the combined effects of landUse on the global carbon–climate system.
Abstract: . Human land-use activities have resulted in large changes to the biogeochemical and biophysical properties of the Earth surface, with consequences for climate and other ecosystem services. In the future, land-use activities are likely to expand and/or intensify further to meet growing demands for food, fiber, and energy. As part of the World Climate Research Program Coupled Model Intercomparison Project (CMIP6), the international community is developing the next generation of advanced Earth System Models (ESMs) to estimate the combined effects of human activities (e.g. land use and fossil fuel emissions) on the carbon-climate system. A new set of historical data based on the History of the Global Environment database (HYDE), and multiple alternative scenarios of the future (2015–2100) from Integrated Assessment Model (IAM) teams, are required as input for these models. Here we present results from the Land-use Harmonization 2 (LUH2) project, with the goal to smoothly connect updated historical reconstructions of land-use with new future projections in the format required for ESMs. The harmonization strategy estimates the fractional land-use patterns, underlying land-use transitions, key agricultural management information, and resulting secondary lands annually, while minimizing the differences between the end of the historical reconstruction and IAM initial conditions and preserving changes depicted by the IAMs in the future. The new approach builds off a similar effort from CMIP5, and is now provided at higher resolution (0.25 × 0.25 degree), over a longer time domain (850–2100, with extensions to 2300), with more detail (including multiple crop and pasture types and associated management practices), using more input datasets (including Landsat remote sensing data), updated algorithms (wood harvest and shifting cultivation), and is assessed via a new diagnostic package. The new LUH2 products contain > 50 times the information content of the datasets used in CMIP5, and are designed to enable new and improved estimates of the combined effects of land-use on the global carbon-climate system.
TL;DR: In this paper, the influence of corporate social responsibility (CSR) on environmental performance, using data from 297 large manufacturing firms in Malaysia, was investigated, and it was shown that CSR has no direct significant influence on environmental performances, but is positively correlated to environmental strategy and green innovation, which again improve environmental performance.
Paris Diderot University1, Durham University2, University of Granada3, Universidade Federal do Espírito Santo4, Universidade Federal de Minas Gerais5, University of Helsinki6, University of Sussex7, University of Massachusetts Amherst8, University of Illinois at Urbana–Champaign9, University of California, San Diego10, University of Stavanger11, Autonomous University of Madrid12, Spanish National Research Council13, University of Mainz14, University of Hamburg15, University of Nottingham16
TL;DR: In this paper, the potential for observing gravitational waves from cosmological phase transitions with LISA was investigated, based on current state-of-the-art simulations of sound waves in the cosmic fluid after the phase transition completes.
Abstract: We investigate the potential for observing gravitational waves from cosmological phase transitions with LISA in light of recent theoretical and experimental developments. Our analysis is based on current state-of-the-art simulations of sound waves in the cosmic fluid after the phase transition completes. We discuss the various sources of gravitational radiation, the underlying parameters describing the phase transition and a variety of viable particle physics models in this context, clarifying common misconceptions that appear in the literature and identifying open questions requiring future study. We also present a web-based tool, PTPlot, that allows users to obtain up-to-date detection prospects for a given set of phase transition parameters at LISA.
TL;DR: There is a need to return to vector control approaches based on a thorough knowledge of the determinants of pathogen transmission, which utilise a range of insecticide and non–insecticide-based approaches in a locally tailored manner for more effective and sustainable vector control.
Abstract: Vector-borne diseases (VBDs) such as malaria, dengue, and leishmaniasis exert a huge burden of morbidity and mortality worldwide, particularly affecting the poorest of the poor. The principal method by which these diseases are controlled is through vector control, which has a long and distinguished history. Vector control, to a greater extent than drugs or vaccines, has been responsible for shrinking the map of many VBDs. Here, we describe the history of vector control programmes worldwide from the late 1800s to date. Pre 1940, vector control relied on a thorough understanding of vector ecology and epidemiology, and implementation of environmental management tailored to the ecology and behaviour of local vector species. This complex understanding was replaced by a simplified dependency on a handful of insecticide-based tools, particularly for malaria control, without an adequate understanding of entomology and epidemiology and without proper monitoring and evaluation. With the rising threat from insecticide-resistant vectors, global environmental change, and the need to incorporate more vector control interventions to eliminate these diseases, we advocate for continued investment in evidence-based vector control. There is a need to return to vector control approaches based on a thorough knowledge of the determinants of pathogen transmission, which utilise a range of insecticide and non-insecticide-based approaches in a locally tailored manner for more effective and sustainable vector control.