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Durham University

EducationDurham, United Kingdom
About: Durham University is a education organization based out in Durham, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 39385 authors who have published 82311 publications receiving 3110994 citations. The organization is also known as: University of Durham & Gallery of Durham University.


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Journal ArticleDOI
TL;DR: This approach is a potentially powerful method of measuring trophic niche width, particularly if combined with conventional approaches, because it provides a single measure on a continuous axis that is common to all species; it integrates information on only assimilated prey over time; and data production is theoretically fast and testing among populations simple.
Abstract: 1. Although conceptually robust, it has proven difficult to find practical measures of niche width that are simple to obtain, yet provide an adequate descriptor of the ecological position of the population examined. 2. Trophic niche has proven more tractable than other niche dimensions. However, indices used as a proxy for trophic niche width often suffer from the following difficulties. Such indices rarely lie along a single scale making comparisons between populations or species difficult; have difficulty in combining dietary prey diversity and evenness in an ecologically meaningful way; and fail to integrate diet over ecological time-scales thus usually only comprise single snapshots of niche width. 3. We propose an alternative novel method for the comparison of trophic niche width: the use of variance of tissue stable isotope ratios, especially those of nitrogen and carbon. 4. This approach is a potentially powerful method of measuring trophic niche width, particularly if combined with conventional approaches, because: it provides a single measure on a continuous axis that is common to all species; it integrates information on only assimilated prey over time; the integration period changes with choice of tissue sampled; and data production is theoretically fast and testing among populations simple. 5. Empirical studies are now required to test the benefits of using isotopic variance as a measure of niche width, and in doing so help refine this approach.

1,171 citations

Journal ArticleDOI
TL;DR: Potential solutions for problems related to the research workforce are proposed, including improvements in protocols and documentation, consideration of evidence from studies in progress, standardisation of research efforts, optimisation and training of an experienced and non-conflicted scientific workforce, and reconsideration of scientific reward systems.

1,169 citations

Journal ArticleDOI
TL;DR: The Dyadic Trust Scale as discussed by the authors is a tool designed for social scientific research to measure personal trust in close relationships, which is an aspect of close relationships which has been virtually ignored in social science research despite its importance.
Abstract: Interpersonal trust is an aspect of close relationships which has been virtually ignored in social scientific research despite its importance as perceived by intimate partners and several family theorists. This article describes the development, validation, and correlates of the Dyadic Trust Scale, a tool designed for such research. It is unidimensional, reliable, relatively free ifrom response biases, and purposely designed to be consistent with conceptualizations qf trust from various perspectives. Dyadic trust proved to be associated with love and with intimacy of self-disclosure, especiallyjfor longer married partners. It varied by level of commitment, being lowest jor ex-partners and highest for those engaged and living together, for newlyweds, and for those married over 20 years. Partners reciprocated trust more than either love or depth qfself-disclosure. Future research could fruitfully relate dyadic trust to such issues as personal growth in relationships, resolving interpersonal conflict, and developing close relationships subsequent to separation or divorce.

1,165 citations

Journal ArticleDOI
TL;DR: In participants with atrial fibrillation undergoing PCI with placement of stents, the administration of either low-dose rivaroxaban plus a P2Y12 inhibitor for 12 months or very-low-dose thrombolysis in Myocardial Infarction plus DAPT for 1, 6, or 12 months was associated with a lower rate of clinically significant bleeding.
Abstract: BackgroundIn patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) with placement of stents, standard anticoagulation with a vitamin K antagonist plus dual antiplatelet therapy (DAPT) with a P2Y12 inhibitor and aspirin reduces the risk of thrombosis and stroke but increases the risk of bleeding. The effectiveness and safety of anticoagulation with rivaroxaban plus either one or two antiplatelet agents are uncertain. MethodsWe randomly assigned 2124 participants with nonvalvular atrial fibrillation who had undergone PCI with stenting to receive, in a 1:1:1 ratio, low-dose rivaroxaban (15 mg once daily) plus a P2Y12 inhibitor for 12 months (group 1), very-low-dose rivaroxaban (2.5 mg twice daily) plus DAPT for 1, 6, or 12 months (group 2), or standard therapy with a dose-adjusted vitamin K antagonist (once daily) plus DAPT for 1, 6, or 12 months (group 3). The primary safety outcome was clinically significant bleeding (a composite of major bleeding or minor bleeding according...

1,164 citations

Journal ArticleDOI
TL;DR: The intricate web of crosstalk among the often redundant multitudes of signaling intermediates is just beginning to be understood and future research employing genome-scale systems biology approaches to solve problems of such magnitude will undoubtedly lead to better understanding of plant development.
Abstract: Being sessile organisms, plants are often exposed to a wide array of abiotic and biotic stresses. Abiotic stress conditions include drought, heat, cold and salinity, whereas biotic stress arises mainly from bacteria, fungi, viruses, nematodes and insects. To adapt to such adverse situations, plants have evolved well-developed mechanisms that help to perceive the stress signal and enable optimal growth response. Phytohormones play critical roles in helping the plants to adapt to adverse environmental conditions. The elaborate hormone signaling networks and their ability to crosstalk make them ideal candidates for mediating defense responses. Recent research findings have helped to clarify the elaborate signaling networks and the sophisticated crosstalk occurring among the different hormone signaling pathways. In this review, we summarize the roles of the major plant hormones in regulating abiotic and biotic stress responses with special focus on the significance of crosstalk between different hormones in generating a sophisticated and efficient stress response. We divided the discussion into the roles of ABA, salicylic acid, jasmonates and ethylene separately at the start of the review. Subsequently, we have discussed the crosstalk among them, followed by crosstalk with growth promoting hormones (gibberellins, auxins and cytokinins). These have been illustrated with examples drawn from selected abiotic and biotic stress responses. The discussion on seed dormancy and germination serves to illustrate the fine balance that can be enforced by the two key hormones ABA and GA in regulating plant responses to environmental signals. The intricate web of crosstalk among the often redundant multitudes of signaling intermediates is just beginning to be understood. Future research employing genome-scale systems biology approaches to solve problems of such magnitude will undoubtedly lead to a better understanding of plant development. Therefore, discovering additional crosstalk mechanisms among various hormones in coordinating growth under stress will be an important theme in the field of abiotic stress research. Such efforts will help to reveal important points of genetic control that can be useful to engineer stress tolerant crops.

1,163 citations


Authors

Showing all 39730 results

NameH-indexPapersCitations
Eugene Braunwald2301711264576
Robert J. Lefkowitz214860147995
David J. Hunter2131836207050
Francis S. Collins196743250787
Robert M. Califf1961561167961
Martin White1962038232387
Eric J. Topol1931373151025
David J. Schlegel193600193972
Simon D. M. White189795231645
George Efstathiou187637156228
Terrie E. Moffitt182594150609
John A. Rogers1771341127390
Avshalom Caspi170524113583
Richard S. Ellis169882136011
Rob Ivison1661161102314
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023182
2022555
20214,695
20204,628
20194,239
20184,047