Institution
Durham University
Education•Durham, United Kingdom•
About: Durham University is a education organization based out in Durham, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 39385 authors who have published 82311 publications receiving 3110994 citations. The organization is also known as: University of Durham & Gallery of Durham University.
Topics: Population, Galaxy, Redshift, Context (language use), Star formation
Papers published on a yearly basis
Papers
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Marcos Daniel Actis1, G. Agnetta2, Felix Aharonian3, A. G. Akhperjanian +682 more•Institutions (109)
TL;DR: The ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes as mentioned in this paper, which is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100GeV and above 100 TeV.
Abstract: Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.
1,006 citations
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TL;DR: A review of the research initial and long-term effects of research abuse was conducted by David Finkelhor and Angela Browne as discussed by the authors, with the focus on high-risk children.
Abstract: Introduction - David Finkelhor Prevalence - Stephanie Doyle Peters, Gail Elizabeth Wyatt and David Finkelhor High Risk Children - David Finkelhor and Larry Baron Abusers - Sharon Araji and David Finkelhor A Review of the Research Abusers - David Finkelhor Special Topics Initial and Long Term Effects - Angela Browne and David Finkelhor A Review of the Research Initial and Long Term Effects - David Finkelhor and Angela Browne A Conceptual Framework Designing New Studies - David Finkelhor Prevention - David Finkelhor A Review of Programs and Research
1,003 citations
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TL;DR: Arguments for the reasonableness of measuring EI as an ability, indicate that correct answers exist, and summarize recent data suggesting that such measures are, indeed, reliable are presented.
Abstract: The authors have claimed that emotional intelligence (EI) meets traditional standards for an intelligence (J. D. Mayer, D. R. Caruso, & P. Salovey, 1999). R. D. Roberts, M. Zeidner, and G. Matthews (2001) questioned whether that claim was warranted. The central issue raised by Roberts et al. concerning Mayer et al. (1999) is whether there are correct answers to questions on tests purporting to measure EI as a set of abilities. To address this issue (and others), the present authors briefly restate their view of intelligence, emotion, and EI. They then present arguments for the reasonableness of measuring EI as an ability, indicate that correct answers exist, and summarize recent data suggesting that such measures are, indeed, reliable.
996 citations
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992 citations
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TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
Abstract: Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection. The mature antibody, CH103, neutralized approximately 55% of HIV-1 isolates, and its co-crystal structure with the HIV-1 envelope protein gp120 revealed a new loop-based mechanism of CD4-binding-site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the unmutated common ancestor of the CH103 lineage avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data determine the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies, and provide insights into strategies to elicit similar antibodies by vaccination.
989 citations
Authors
Showing all 39730 results
Name | H-index | Papers | Citations |
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Eugene Braunwald | 230 | 1711 | 264576 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
David J. Hunter | 213 | 1836 | 207050 |
Francis S. Collins | 196 | 743 | 250787 |
Robert M. Califf | 196 | 1561 | 167961 |
Martin White | 196 | 2038 | 232387 |
Eric J. Topol | 193 | 1373 | 151025 |
David J. Schlegel | 193 | 600 | 193972 |
Simon D. M. White | 189 | 795 | 231645 |
George Efstathiou | 187 | 637 | 156228 |
Terrie E. Moffitt | 182 | 594 | 150609 |
John A. Rogers | 177 | 1341 | 127390 |
Avshalom Caspi | 170 | 524 | 113583 |
Richard S. Ellis | 169 | 882 | 136011 |
Rob Ivison | 166 | 1161 | 102314 |