Institution
Durham University
Education•Durham, United Kingdom•
About: Durham University is a education organization based out in Durham, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 39385 authors who have published 82311 publications receiving 3110994 citations. The organization is also known as: University of Durham & Gallery of Durham University.
Topics: Population, Galaxy, Redshift, Context (language use), Star formation
Papers published on a yearly basis
Papers
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TL;DR: Better ways of identifying which patients will respond to specific treatments are urgently needed for the assessment and management of adult patients with irritable bowel syndrome.
Abstract: Background: IBS affects 5–11% of the population of most countries. Prevalence peaks in the third and fourth decades, with a female predominance. Aim: To provide a guide for the assessment and management of adult patients with irritable bowel syndrome. Methods: Members of the Clinical Services Committee of The British Society of Gastroenterology were allocated particular areas to produce review documents. Literature searching included systematic searches using electronic databases such as Pubmed, EMBASE, MEDLINE, Web of Science, and Cochrane databases and extensive personal reference databases. Results: Patients can usefully be classified by predominant bowel habit. Few investigations are needed except when diarrhoea is a prominent feature. Alarm features may warrant further investigation. Adverse psychological features and somatisation are often present. Ascertaining the patients’ concerns and explaining symptoms in simple terms improves outcome. IBS is a heterogeneous condition with a range of treatments, each of which benefits a small proportion of patients. Treatment of associated anxiety and depression often improves bowel and other symptoms. Randomised placebo controlled trials show benefit as follows: cognitive behavioural therapy and psychodynamic interpersonal therapy improve coping; hypnotherapy benefits global symptoms in otherwise refractory patients; antispasmodics and tricyclic antidepressants improve pain; ispaghula improves pain and bowel habit; 5-HT 3 antagonists improve global symptoms, diarrhoea, and pain but may rarely cause unexplained colitis; 5-HT 4 agonists improve global symptoms, constipation, and bloating; selective serotonin reuptake inhibitors improve global symptoms. Conclusions: Better ways of identifying which patients will respond to specific treatments are urgently needed.
816 citations
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Liverpool John Moores University1, University of Chester2, Max Planck Society3, Oxford Brookes University4, McGill University5, University of Massachusetts Dartmouth6, New York University7, British Academy8, University of Oxford9, University of Lethbridge10, Michigan State University11, Bournemouth University12, Durham University13, University of Stirling14, Instituto Politécnico Nacional15, University of Wisconsin-Madison16, University of Zurich17
TL;DR: In this paper, a new framework for integrating current knowledge on fission-fusion dynamics emerged from a fundamental rethinking of the term fission fusion away from its current general use as a label for a particular modal type of social system.
Abstract: Renewed interest in fission‐fusion dynamics is due to the recognition that such dynamics may create unique challenges for social interaction and distinctive selective pressures acting on underlying communicative and cognitive abilities. New frameworks for integrating current knowledge on fission‐fusion dynamics emerge from a fundamental rethinking of the term “fission‐fusion” away from its current general use as a label for a particular modal type of social system (i.e., “fission‐fusion societies”). Specifically, because the degree of spatial and temporal cohesion of group members varies both within and across taxa, any social system can be described in terms of the extent to which it expresses fission‐fusion dynamics. This perspective has implications for socioecology, communication, cognitive demands, and human social evolution.
816 citations
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University of Edinburgh1, Durham University2, Australian National University3, Liverpool John Moores University4, University of New South Wales5, University of Oxford6, University of St Andrews7, University of Cambridge8, California Institute of Technology9, Johns Hopkins University10, University of Leeds11, University of Nottingham12
TL;DR: In this paper, the authors presented the power spectrum of the galaxy distribution, calculated using a direct Fourier transform based technique and showed that within the k-space region 0.02 less than or similar to k less than and similar to 0.15 h Mpc(-1), the shape of this spectrum should be close to that of the linear density perturbations convolved with the window function of the survey.
Abstract: The 2dF Galaxy Redshift Survey has now measured in excess of 160 000 galaxy redshifts. This paper presents the power spectrum of the galaxy distribution, calculated using a direct Fourier transform based technique. We argue that, within the k-space region 0.02 less than or similar to k less than or similar to 0.15 h Mpc(-1), the shape of this spectrum should be close to that of the linear density perturbations convolved with the window function of the survey. This window function and its convolving effect on the power spectrum estimate are analysed in detail. By convolving model spectra, we are able to fit the power-spectrum data and provide a measure of the matter content of the Universe. Our results show that models containing baryon oscillations are mildly preferred over featureless power spectra. Analysis of the data yields 68 per cent confidence limits on the total matter density times the Hubble parameter Omega (m) h = 0.20 +/- 0.03, and the baryon fraction Omega (b)/Omega (m) = 0.15 +/- 0.07, assuming scale-invariant primordial fluctuations.
812 citations
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TL;DR: Following neuronal induction of murine and human ADAS cells, Western blot analysis confirmed GFAP, nestin, and NeuN protein expression and Pretreatment with EGF and basic FGF augmented the neuronal differentiation of huADAS cells.
811 citations
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University of Nottingham1, Durham University2, University of Cambridge3, University of California, Berkeley4, University of Edinburgh5, Johns Hopkins University6, Australian National University7, Liverpool John Moores University8, University of New South Wales9, University of Oxford10, Rutherford Appleton Laboratory11, California Institute of Technology12, University of Leeds13
TL;DR: In this article, a detailed analysis of the two-point correlation function, ξ(σ, π), from the 2dF Galaxy Redshift Survey (2dFGRS) is presented.
Abstract: We present a detailed analysis of the two-point correlation function, ξ(σ, π), from the 2dF Galaxy Redshift Survey (2dFGRS). The large size of the catalogue, which contains ∼220 000 redshifts, allows us to make high-precision measurements of various properties of the galaxy clustering pattern. The effective redshift at which our estimates are made is zs≈ 0.15, and similarly the effective luminosity, Ls≈ 1.4L*. We estimate the redshift-space correlation function, ξ(s), from which we measure the redshift-space clustering length, s0= 6.82 ± 0.28 h−1 Mpc. We also estimate the projected correlation function, Ξ(σ), and the real-space correlation function, ξ(r), which can be fit by a power law (r/r0), with r0= 5.05 ± 0.26 h−1 Mpc, γr= 1.67 ± 0.03. For r≳ 20 h−1 Mpc, ξ drops below a power law as, for instance, is expected in the popular Λ cold dark matter model. The ratio of amplitudes of the real- and redshift-space correlation functions on scales of 8–30 h−1 Mpc gives an estimate of the redshift-space distortion parameter β. The quadrupole moment of ξ(σ, π) on scales 30–40 h−1 Mpc provides another estimate of β. We also estimate the distribution function of pairwise peculiar velocities, ƒ(v), including rigorously the significant effect due to the infall velocities, and we find that the distribution is well fit by an exponential form. The accuracy of our ξ(σ, π) measurement is sufficient to constrain a model, which simultaneously fits the shape and amplitude of ξ(r) and the two redshift-space distortion effects parametrized by β and velocity dispersion, a. We find β= 0.49 ± 0.09 and a= 506 ± 52 km s−1, although the best-fitting values are strongly correlated. We measure the variation of the peculiar velocity dispersion with projected separation, a(σ), and find that the shape is consistent with models and simulations. This is the first time that β and ƒ(v) have been estimated from a self-consistent model of galaxy velocities. Using the constraints on bias from recent estimates, and taking account of redshift evolution, we conclude that β (L=L*, z= 0) = 0.47 ± 0.08, and that the present-day matter density of the Universe, Ωm≈ 0.3, consistent with other 2dFGRS estimates and independent analyses.
811 citations
Authors
Showing all 39730 results
Name | H-index | Papers | Citations |
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Eugene Braunwald | 230 | 1711 | 264576 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
David J. Hunter | 213 | 1836 | 207050 |
Francis S. Collins | 196 | 743 | 250787 |
Robert M. Califf | 196 | 1561 | 167961 |
Martin White | 196 | 2038 | 232387 |
Eric J. Topol | 193 | 1373 | 151025 |
David J. Schlegel | 193 | 600 | 193972 |
Simon D. M. White | 189 | 795 | 231645 |
George Efstathiou | 187 | 637 | 156228 |
Terrie E. Moffitt | 182 | 594 | 150609 |
John A. Rogers | 177 | 1341 | 127390 |
Avshalom Caspi | 170 | 524 | 113583 |
Richard S. Ellis | 169 | 882 | 136011 |
Rob Ivison | 166 | 1161 | 102314 |