Showing papers by "Durham University published in 2013"

THE NUCLEAR SPECTROSCOPIC TELESCOPE ARRAY (NuSTAR) HIGH-ENERGY X-RAY MISSION

Abstract: The Nuclear Spectroscopic Telescope Array (NuSTAR) mission, launched on 2012 June 13, is the first focusing high-energy X-ray telescope in orbit. NuSTAR operates in the band from 3 to 79 keV, extending the sensitivity of focusing far beyond the ~10 keV high-energy cutoff achieved by all previous X-ray satellites. The inherently low background associated with concentrating the X-ray light enables NuSTAR to probe the hard X-ray sky with a more than 100-fold improvement in sensitivity over the collimated or coded mask instruments that have operated in this bandpass. Using its unprecedented combination of sensitivity and spatial and spectral resolution, NuSTAR will pursue five primary scientific objectives: (1) probe obscured active galactic nucleus (AGN) activity out to the peak epoch of galaxy assembly in the universe (at z ≾ 2) by surveying selected regions of the sky; (2) study the population of hard X-ray-emitting compact objects in the Galaxy by mapping the central regions of the Milky Way; (3) study the non-thermal radiation in young supernova remnants, both the hard X-ray continuum and the emission from the radioactive element ^(44)Ti; (4) observe blazars contemporaneously with ground-based radio, optical, and TeV telescopes, as well as with Fermi and Swift, to constrain the structure of AGN jets; and (5) observe line and continuum emission from core-collapse supernovae in the Local Group, and from nearby Type Ia events, to constrain explosion models. During its baseline two-year mission, NuSTAR will also undertake a broad program of targeted observations. The observatory consists of two co-aligned grazing-incidence X-ray telescopes pointed at celestial targets by a three-axis stabilized spacecraft. Deployed into a 600 km, near-circular, 6° inclination orbit, the observatory has now completed commissioning, and is performing consistent with pre-launch expectations. NuSTAR is now executing its primary science mission, and with an expected orbit lifetime of 10 yr, we anticipate proposing a guest investigator program, to begin in late 2014.

Cosmology and Fundamental Physics with the Euclid Satellite

Abstract: Euclid is a European Space Agency medium-class mission selected for launch in 2020 within the cosmic vision 2015–2025 program. The main goal of Euclid is to understand the origin of the accelerated expansion of the universe. Euclid will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky. Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research. In this review we focus on cosmology and fundamental physics, with a strong emphasis on science beyond the current standard models. We discuss five broad topics: dark energy and modified gravity, dark matter, initial conditions, basic assumptions and questions of methodology in the data analysis. This review has been planned and carried out within Euclid’s Theory Working Group and is meant to provide a guide to the scientific themes that will underlie the activity of the group during the preparation of the Euclid mission.

Innovative instructions and software model for isolated execution

Abstract: For years the PC community has struggled to provide secure solutions on open platforms. Intel has developed innovative new technology to enable SW developers to develop and deploy secure applications on open platforms. The technology enables applications to execute with confidentiality and integrity in the native OS environment. It does this by providing ISA extensions for generating hardware enforceable containers at a granularity determined by the developer. These containers while opaque to the operating system are managed by the OS. This paper analyzes the threats and attacks to applications. It then describes the ISA extension for generating a HW based container. Finally it describes the programming model of this container.

Green Human Resource Management: A Review and Research Agenda*

Abstract: The paper makes a case for the integration of the largely separate literatures of environmental management (EM) and human resource management (HRM) research. The paper categorizes the existing literature on the basis of Ability–Motivation– Opportunity (AMO) theory, revealing the role that Green human resource management (GHRM) processes play in people-management practice. The contributions of the paper lie in drawing together the extant literature in the area, mapping the terrain of the field, identifying some gaps in the existing literature and suggesting some potentially fruitful future research agendas. The findings of the review suggest that understanding of how GHRM practices influence employee motivation to become involved in environmental activities lags behind that of how organizations develop Green abilities and provide employees with opportunities to be involved in EM organizational efforts. Organizations are not using the full range of GHRM practices, and this may limit their effectiveness in efforts to improve EM.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Abstract: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4α, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. HNF-4α), resulting in up- and downregulation of hundreds of genes. An understanding of these changes is crucial for a correct interpretation of in vitro data. The possibilities and limitations of the most useful liver in vitro systems are summarized, including three-dimensional culture techniques, co-cultures with non-parenchymal cells, hepatospheres, precision cut liver slices and the isolated perfused liver. Also discussed is how closely hepatoma, stem cell and iPS cell-derived hepatocyte-like-cells resemble real hepatocytes. Finally, a summary is given of the state of the art of liver in vitro and mathematical modeling systems that are currently used in the pharmaceutical industry with an emphasis on drug metabolism, prediction of clearance, drug interaction, transporter studies and hepatotoxicity. One key message is that despite our enthusiasm for in vitro systems, we must never lose sight of the in vivo situation. Although hepatocytes have been isolated for decades, the hunt for relevant alternative systems has only just begun.

The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem

Abstract: Background: Concerns for arsenic exposure are not limited to toxic waste sites and massive poisoning events. Chronic exposure continues to be a major public health problem worldwide, affecting hundreds of millions of persons. Objectives: We reviewed recent information on worldwide concerns for arsenic exposures and public health to heighten awareness of the current scope of arsenic exposure and health outcomes and the importance of reducing exposure, particularly during pregnancy and early life. Methods: We synthesized the large body of current research pertaining to arsenic exposure and health outcomes with an emphasis on recent publications. Discussion: Locations of high arsenic exposure via drinking water span from Bangladesh, Chile, and Taiwan to the United States. The U.S. Environmental Protection Agency maximum contaminant level (MCL) in drinking water is 10 µg/L; however, concentrations of > 3,000 µg/L have been found in wells in the United States. In addition, exposure through diet is of growing concern. Knowledge of the scope of arsenic-associated health effects has broadened; arsenic leaves essentially no bodily system untouched. Arsenic is a known carcinogen associated with skin, lung, bladder, kidney, and liver cancer. Dermatological, developmental, neurological, respiratory, cardiovascular, immunological, and endocrine effects are also evident. Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood. Conclusions: These data call for heightened awareness of arsenic-related pathologies in broader contexts than previously perceived. Testing foods and drinking water for arsenic, including individual private wells, should be a top priority to reduce exposure, particularly for pregnant women and children, given the potential for life-long effects of developmental exposure.

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Abstract: Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection. The mature antibody, CH103, neutralized approximately 55% of HIV-1 isolates, and its co-crystal structure with the HIV-1 envelope protein gp120 revealed a new loop-based mechanism of CD4-binding-site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the unmutated common ancestor of the CH103 lineage avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data determine the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies, and provide insights into strategies to elicit similar antibodies by vaccination.

Topographic structure from motion: a new development in photogrammetric measurement

Abstract: The production of topographic datasets is of increasing interest and application throughout the geomorphic sciences, and river science is no exception. Consequently, a wide range of topographic measurement methods have evolved. Despite the range of available methods, the production of high resolution, high quality digital elevation models (DEMs) requires a significant investment in personnel time, hardware and/or software. However, image-based methods such as digital photogrammetry have been decreasing in costs. Developed for the purpose of rapid, inexpensive and easy three-dimensional surveys of buildings or small objects, the ‘structure from motion’ photogrammetric approach (SfM) is an image-based method which could deliver a methodological leap if transferred to geomorphic applications, requires little training and is extremely inexpensive. Using an online SfM program, we created high-resolution digital elevation models of a river environment from ordinary photographs produced from a workflow that takes advantage of free and open source software. This process reconstructs real world scenes from SfM algorithms based on the derived positions of the photographs in three-dimensional space. The basic product of the SfM process is a point cloud of identifiable features present in the input photographs. This point cloud can be georeferenced from a small number of ground control points collected in the field or from measurements of camera positions at the time of image acquisition. The georeferenced point cloud can then be used to create a variety of digital elevation products. We examine the applicability of SfM in the Pedernales River in Texas (USA), where several hundred images taken from a hand-held helikite are used to produce DEMs of the fluvial topographic environment. This test shows that SfM and low-altitude platforms can produce point clouds with point densities comparable with airborne LiDAR, with horizontal and vertical precision in the centimeter range, and with very low capital and labor costs and low expertise levels. Copyright © 2012 John Wiley & Sons, Ltd.

Higher levels of multiple ecosystem services are found in forests with more tree species

Abstract: Forests are of major importance to human society, contributing several crucial ecosystem services. Biodiversity is suggested to positively influence multiple services but evidence from natural systems at scales relevant to management is scarce. Here, across a scale of 400,000 km(2), we report that tree species richness in production forests shows positive to positively hump-shaped relationships with multiple ecosystem services. These include production of tree biomass, soil carbon storage, berry production and game production potential. For example, biomass production was approximately 50% greater with five than with one tree species. In addition, we show positive relationships between tree species richness and proxies for other biodiversity components. Importantly, no single tree species was able to promote all services, and some services were negatively correlated to each other. Management of production forests will therefore benefit from considering multiple tree species to sustain the full range of benefits that the society obtains from forests.

Government by experiment? Global cities and the governing of climate change

Abstract: In this paper, we argue for an approach that goes beyond an institutional reading of urban climate governance to engage with the ways in which government is accomplished through social and technical practices. Central to the exercise of government in this manner, we argue, are ‘climate change experiments’– purposive interventions in urban socio-technical systems designed to respond to the imperatives of mitigating and adapting to climate change in the city. Drawing on three different concepts – of governance experiments, socio-technical experiments, and strategic experiments – we first develop a framework for understanding the nature and dynamics of urban climate change experiments. We use this conceptual analysis to frame a scoping study of the global dimensions of urban climate change experimentation in a database of 627 urban climate change experiments in 100 global cities. The analysis charts when and where these experiments occur, the relationship between the social and technical aspects of experimentation and the governance of urban climate change experimentation, including the actors involved in their governing and the extent to which new political spaces for experimentation are emerging in the contemporary city. We find that experiments serve to create new forms of political space within the city, as public and private authority blur, and are primarily enacted through forms of technical intervention in infrastructure networks, drawing attention to the importance of such sites in urban climate politics. These findings point to an emerging research agenda on urban climate change experiments that needs to engage with the diversity of experimentation in different urban contexts, how they are conducted in practice and their impacts and implications for urban governance and urban life.

A survey of urban climate change experiments in 100 cities

Abstract: Cities are key sites where climate change is being addressed. Previous research has largely overlooked the multiplicity of climate change responses emerging outside formal contexts of decision-making and led by actors other than municipal governments. Moreover, existing research has largely focused on case studies of climate change mitigation in developed economies. The objective of this paper is to uncover the heterogeneous mix of actors, settings, governance arrangements and technologies involved in the governance of climate change in cities in different parts of the world. The paper focuses on urban climate change governance as a process of experimentation. Climate change experiments are presented here as interventions to try out new ideas and methods in the context of future uncertainties. They serve to understand how interventions work in practice, in new contexts where they are thought of as innovative. To study experimentation, the paper presents evidence from the analysis of a database of 627 urban climate change experiments in a sample of 100 global cities. The analysis suggests that, since 2005, experimentation is a feature of urban responses to climate change across different world regions and multiple sectors. Although experimentation does not appear to be related to particular kinds of urban economic and social conditions, some of its core features are visible. For example, experimentation tends to focus on energy. Also, both social and technical forms of experimentation are visible, but technical experimentation is more common in urban infrastructure systems. While municipal governments have a critical role in climate change experimentation, they often act alongside other actors and in a variety of forms of partnership. These findings point at experimentation as a key tool to open up new political spaces for governing climate change in the city.

Neutrino Mass and Mixing with Discrete Symmetry

Abstract: This is a review paper about neutrino mass and mixing and flavour model building strategies based on discrete family symmetry. After a pedagogical introduction and overview of the whole of neutrino physics, we focus on the PMNS mixing matrix and the latest global fits following the Daya Bay and RENO experiments which measure the reactor angle. We then describe the simple bimaximal, tri-bimaximal and golden ratio patterns of lepton mixing and the deviations required for a non-zero reactor angle, with solar or atmospheric mixing sum rules resulting from charged lepton corrections or residual trimaximal mixing. The different types of see-saw mechanism are then reviewed as well as the sequential dominance mechanism. We then give a mini-review of finite group theory, which may be used as a discrete family symmetry broken by flavons either completely, or with different subgroups preserved in the neutrino and charged lepton sectors. These two approaches are then reviewed in detail in separate chapters including mechanisms for flavon vacuum alignment and different model building strategies that have been proposed to generate the reactor angle. We then briefly review grand unified theories (GUTs) and how they may be combined with discrete family symmetry to describe all quark and lepton masses and mixing. Finally, we discuss three model examples which combine an SU(5) GUT with the discrete family symmetries A₄, S₄ and Δ(96).

Triplet harvesting with 100% efficiency by way of thermally activated delayed fluorescence in charge transfer OLED emitters.

Abstract: Organic light-emitting diodes (OLEDs) have their performance limited by the number of emissive singlet states created upon charge recombination (25%). Recently, a novel strategy has been proposed, based on thermally activated up-conversion of triplet to singlet states, yielding delayed fluorescence (TADF), which greatly enhances electroluminescence. The energy barrier for this reverse intersystem crossing mechanism is proportional to the exchange energy (ΔEST ) between the singlet and triplet states; therefore, materials with intramolecular charge transfer (ICT) states, where it is known that the exchange energy is small, are perfect candidates. However, here it is shown that triplet states can be harvested with 100% efficiency via TADF, even in materials with ΔEST of more than 20 kT (where k is the Boltzmann constant and T is the temperature) at room temperature. The key role played by lone pair electrons in achieving this high efficiency in a series of ICT molecules is elucidated. The results show the complex photophysics of efficient TADF materials and give clear guidelines for designing new emitters.

The Financial Toxicity of Cancer Treatment: A Pilot Study Assessing Out-of-Pocket Expenses and the Insured Cancer Patient's Experience

Abstract: Purpose. Cancer patients carry rising burdens of health care-related out-of-pocket expenses, and a growing number of patients are considered “underinsured.” Our objective was to describe experiences of insured cancer patients requesting copayment assistance and to describe the impact of health care expenses on well-being and treatment.

How bad are the effects of bad leaders? A meta-analysis of destructive leadership and its outcomes

Abstract: While the focus on constructive leadership still dominates leadership research, an increasing number of studies investigate different forms of destructive leadership. This meta-analysis integrates different conceptualizations of destructive leadership and analyzes the relationship between destructive leadership and outcome variables. The search for articles yielded more than 200 studies of which 57 could be included in the meta-analysis. Results indicate the expected negative correlations with positive followers' outcomes and behaviors (e.g., attitudes towards the leader, well-being, and individual performance) and positive correlations with negative outcomes (e.g., turnover intention, resistance towards the leader, counterproductive work behavior). As expected, the highest correlation arises between destructive leadership and attitudes towards the leader. Surprisingly, the next highest correlation was found between destructive leadership and counterproductive work behavior. After discussing the results, an agenda for future research is proposed. Given the negative impact of destructive leadership, more knowledge is especially necessary regarding what triggers destructive leadership.

Scaling the Ion Trap Quantum Processor

Abstract: Trapped atomic ions are standards for quantum information processing, serving as quantum memories, hosts of quantum gates in quantum computers and simulators, and nodes of quantum communication networks. Quantum bits based on trapped ions enjoy a rare combination of attributes: They have exquisite coherence properties, they can be prepared and measured with nearly 100% efficiency, and they are readily entangled with each other through the Coulomb interaction or remote photonic interconnects. The outstanding challenge is the scaling of trapped ions to hundreds or thousands of qubits and beyond, at which scale quantum processors can outperform their classical counterparts in certain applications. We review the latest progress and prospects in that effort, with the promise of advanced architectures and new technologies, such as microfabricated ion traps and integrated photonics.

10 × '20 Progress—Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

Abstract: Infections caused by antibiotic-resistant bacteria, especially the “ESKAPE” pathogens, continue to increase in frequency and cause significant morbidity and mortality. New antimicrobial agents are greatly needed to treat infections caused by gram-negative bacilli (GNB) resistant to currently available agents. The Infectious Diseases Society of America (IDSA) continues to propose legislative, regulatory, and funding solutions to this continuing crisis. The current report updates the status of development and approval of systemic antibiotics in the United States as of early 2013. Only 2 new antibiotics have been approved since IDSA's 2009 pipeline status report, and the number of new antibiotics annually approved for marketing in the United States continues to decline. We identified 7 drugs in clinical development for treatment of infections caused by resistant GNB. None of these agents was included in our 2009 list of antibacterial compounds in phase 2 or later development, but unfortunately none addresses the entire spectrum of clinically relevant GNB resistance. Our survey demonstrates some progress in development of new antibacterial drugs that target infections caused by resistant GNB, but progress remains alarmingly elusive. IDSA stresses our conviction that the antibiotic pipeline problem can be solved by the collaboration of global leaders to develop creative incentives that will stimulate new antibacterial research and development. Our aim is the creation of a sustainable global antibacterial drug research and development enterprise with the power in the short term to develop 10 new, safe, and efficacious systemically administered antibiotics by 2020 as called for in IDSA's “10 × '20 Initiative.”

PRIMUS: Constraints on Star Formation Quenching and Galaxy Merging, and the Evolution of the Stellar Mass Function from z = 0-1

Abstract: We measure the evolution of the stellar mass function (SMF) from z = 0−1 using multi-wavelength imaging and spectroscopic redshifts from the PRism MUlti-object Survey (PRIMUS) and the Sloan Digital Sky Survey (SDSS). From PRIMUS we construct an i < 23 flux-limited sample of ∼ 40,000 galaxies at z = 0.2 − 1.0 over five fields totaling ≈ 5.5 deg 2 , and from the SDSS we select ∼ 170,000 galaxies atz = 0.01−0.2 that we analyze consistently with respect to PRIMUS to minimize systematic errors in our evolutionary measurements. We find that the SMF of all galaxies evolves relatively little since z = 1, although we do find evidence for mass assembly downsizing; we measure a ≈ 30% increase in the number density of ∼ 10 10 M⊙ galaxies sincez ≈ 0.6, and a . 10% change in the number density of all & 10 11 M⊙ galaxies since z ≈ 1. Dividing the sample into star-forming and quiescent using an evolving cut in specific star-formation rate, we find that the number density of ∼ 10 10 M⊙ star-forming galaxies stays relatively constant since z ≈ 0.6, whereas the space-density of & 10 11 M⊙ star-forming galaxies decreases by ≈ 50% between z ≈ 1 and z ≈ 0. Meanwhile, the number density of ∼ 10 10 M⊙ quiescent galaxies increases steeply towards low redshift, by a factor of ∼ 2 − 3 since z ≈ 0.6, while the number of massive quiescent galaxies remains approximately constant since z ≈ 1. These results suggest that the rate at which star-forming galaxies are quenched increases with decreasing stellar mass, but that the bulk of the stellar mass buildup within the quiescent population occurs around ∼ 10 10.8 M⊙. In addition, we conclude that mergers do not appear to be a dominant channel for the stellar mass buildup of galaxies at z < 1, even among massive (& 10 11 M⊙) quiescent galaxies. Subject headings: Surveys – galaxies: evolution – galaxies: high-redshift – cosmology: large-scale structure of universe

Graphene synthesis: relationship to applications.

Abstract: Graphene is a true wonder material that promises much in a variety of applications that include electronic devices, supercapacitors, batteries, composites, flexible transparent displays and sensors. This review highlights the different methods available for the synthesis of graphene and discusses the viability and practicalities of using the materials produced via these methods for different graphene-based applications.

ACR guidance document on MR safe practices: 2013.

Abstract: Because there are many potential risks in the MR environment and reports of adverse incidents involving patients, equipment and personnel, the need for a guidance document on MR safe practices emerged. Initially published in 2002, the ACR MR Safe Practices Guidelines established de facto industry standards for safe and responsible practices in clinical and research MR environments. As the MR industry changes the document is reviewed, modified and updated. The most recent version will reflect these changes.

SCUBA-2: the 10 000 pixel bolometer camera on the James Clerk Maxwell Telescope

Abstract: SCUBA-2 is an innovative 10000 pixel bolometer camera operating at submillimetre wavelengths on the James Clerk Maxwell Telescope (JCMT). The camera has the capability to carry out wide-field surveys to unprecedented depths, addressing key questions relating to the origins of galaxies, stars and planets. With two imaging arrays working simultaneously in the atmospheric windows at 450 and 850µm, the vast increase in pixel count means that SCUBA-2 maps the sky 100–150 times faster than the previous SCUBA instrument. In this paper we present an overview of the instrument, discuss the physical characteristics of the superconducting detector arrays, outline the observing modes and data acquisition, and present the early performance figures on the telescope. We also showcase the capabilities of the instrument via some early examples of the science SCUBA-2 has already undertaken. In February 2012, SCUBA-2 began a series of unique legacy surveys for the JCMT community. These surveys will take 2.5years and the results are already providing complementary data to the shorter wavelength, shallower, larger-area surveys from Herschel. The SCUBA-2 surveys will also provide a wealth of information for further study with new facilities such as ALMA, and future telescopes such as CCAT and SPICA.

is volunteering a public health intervention? a systematic review and meta-analysis of the health and survival of volunteers

Abstract: Background: Volunteering has been advocated by the United Nations, and American and European governments as a way to engage people in their local communities and improve social capital, with the potential for public health benefits such as improving wellbeing and decreasing health inequalities Furthermore, the US Corporation for National and Community Service Strategic Plan for 2011–2015 focused on increasing the impact of national service on community needs, supporting volunteers’ wellbeing, and prioritising recruitment and engagement of underrepresented populations The aims of this review were to examine the effect of formal volunteering on volunteers’ physical and mental health and survival, and to explore the influence of volunteering type and intensity on health outcomes Methods: Experimental and cohort studies comparing the physical and mental health outcomes and mortality of a volunteering group to a non-volunteering group were identified from twelve electronic databases (Cochrane Library, Medline, Embase, PsychINFO, CINAHL, ERIC, HMIC, SSCI, ASSIA, Social Care Online, Social Policy and Practice) and citation tracking in January 2013 No language, country or date restrictions were applied Data synthesis was based on vote counting and random effects meta-analysis of mortality risk ratios Results: Forty papers were selected: five randomised controlled trials (RCTs, seven papers); four non-RCTs; and 17 cohort studies (29 papers) Cohort studies showed volunteering had favourable effects on depression, life satisfaction, wellbeing but not on physical health These findings were not confirmed by experimental studies Meta-analysis of five cohort studies found volunteers to be at lower risk of mortality (risk ratio: 078; 95% CI: 066, 090) There was insufficient evidence to demonstrate a consistent influence of volunteering type or intensity on outcomes Conclusion: Observational evidence suggested that volunteering may benefit mental health and survival although the causal mechanisms remain unclear Consequently, there was limited robustly designed research to guide the development of volunteering as a public health promotion intervention Future studies should explicitly map intervention design to clear health outcomes as well as use pragmatic RCT methodology to test effects