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Institution

Eppley Institute for Research in Cancer and Allied Diseases

About: Eppley Institute for Research in Cancer and Allied Diseases is a based out in . It is known for research contribution in the topics: Pancreatic cancer & Cancer. The organization has 965 authors who have published 1396 publications receiving 58994 citations.
Topics: Pancreatic cancer, Cancer, DNA, Gene, Cancer cell


Papers
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Journal ArticleDOI
TL;DR: It is hypothesised that CNS vacuolation in Mgrn1 null mice may be caused by the accumulation of multi‐cisternal endosome‐like ‘class E’ vacuolar protein sorting (vps) compartments similar to those observed in Tsg101‐depleted cells in culture.

13 citations

Journal ArticleDOI
TL;DR: Binding of duplex DNA by polymeric RNA might be improved by optimizing the RNA structure to efficiently present the recognition sequence, and reduced affinity suggests that reduced affinity arises from unfavorable electrostatic, structural and topological considerations.
Abstract: We are interested in creating artificial gene repressors based on duplex DNA recognition by nucleic acids. Homopyrimidine RNA oligonucleotides bind to duplex DNA at homopurine/homopyrimidine sequences under slightly acidic conditions. Recognition is sequence-specific, involving rU.dA.dT and rC+.dG.dC base triplets. Affinities were determined for folded polymeric RNAs (ca. 100-200 nt) containing 0, 1 or 3 copies of a 21 nt RNA sequence that binds duplex DNA by triple helix formation. When this recognition sequence was inserted into the larger folded RNAs, micromolar concentrations of the resulting RNA ligands bound a duplex DNA target at pH 5. However, these binding affinities were at least 20-fold lower than the affinity of an RNA oligonucleotide containing only the recognition sequence. Enzymatic probing of folded RNAs suggests that reduced affinity arises from unfavorable electrostatic, structural and topological considerations. The affinity of a polymeric RNA with three copies of the recognition sequence was greater than that of a polymeric RNA with a single copy of the sequence. This affinity difference ranged from 2.6- to 13-fold, depending on pH. Binding of duplex DNA by polymeric RNA might be improved by optimizing the RNA structure to efficiently present the recognition sequence.

13 citations

Journal ArticleDOI
TL;DR: Evidence is presented that the combination of many factors, including the structure of the template/primer, the identity of the metal, the metal turnover in the pol active site, and the influence of the concentration of nucleoside triphosphates, affect DNA pol synthesis.

13 citations

Journal ArticleDOI
TL;DR: The results indicate that an important metabolic pathway for NMA, with both inducing agents, entails an initial denitrosation to yield MA, which in turn rapidly undergoes oxidative demethylation to aniline, which suggests that direct dem methylation of NMA in the phenobarbital-induced system is an important metabolism pathway.

13 citations

Journal ArticleDOI
TL;DR: Conventional PKCs appear generally insensitive to desensitization by sustained diacylglycerol stimulation, and prolonged (several-day) membrane association/activation of PKCα is seen in self-renewing epithelium of the intestine, cervix, and skin.

13 citations


Authors

Showing all 965 results

NameH-indexPapersCitations
Michael R. Green12653757447
Henrik Clausen10952049820
Howard E. Gendelman10156739460
James O. Armitage9755859171
Surinder K. Batra8756430653
Michael L. Gross8270127140
Michael A. Hollingsworth7624924460
Peter M. J. Burgers7316716123
Patrick L. Iversen6831913707
J. Alan Diehl6716819966
Samuel M. Cohen6542115940
Kenneth H. Cowan6417814094
Gangning Liang6015018081
Michael G. Brattain5919913199
Thomas E. Smithgall571848904
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20223
202188
202069
201964
201842
201757