Institution
Eppley Institute for Research in Cancer and Allied Diseases
About: Eppley Institute for Research in Cancer and Allied Diseases is a based out in . It is known for research contribution in the topics: Pancreatic cancer & Cancer. The organization has 965 authors who have published 1396 publications receiving 58994 citations.
Topics: Pancreatic cancer, Cancer, DNA, Gene, Cancer cell
Papers published on a yearly basis
Papers
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Cornell University1, University of Pennsylvania2, NewYork–Presbyterian Hospital3, Hannover Medical School4, Rockefeller University5, National Taiwan University6, Oslo University Hospital7, University of Oslo8, Memorial Sloan Kettering Cancer Center9, Eppley Institute for Research in Cancer and Allied Diseases10, University of Nebraska Medical Center11
TL;DR: It is shown that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden and suggests that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.
Abstract: Lyden and colleagues report that pancreatic cancer-derived exosomes induce a pre-metastatic niche in the liver by promoting TGFβ secretion from Kupffer cells, leading to fibronectin production in hepatic stellate cells and macrophage recruitment.
1,973 citations
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TL;DR: Mucins — large extracellular proteins that are heavily glycosylated with complex oligosaccharides — establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction.
Abstract: Mucins — large extracellular proteins that are heavily glycosylated with complex oligosaccharides — establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.
1,657 citations
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TL;DR: Using frequently occurring residues, database-aided peptide design in different ways is demonstrated, and GLK-19 showed a higher activity against Escherichia coli than human LL-37 and Leu, Ala, Gly and Lys in amphibian peptides.
Abstract: The antimicrobial peptide database (APD, http://aps.unmc.edu/AP/main.php) has been updated and expanded. It now hosts 1228 entries with 65 anticancer, 76 antiviral (53 anti-HIV), 327 antifungal and 944 antibacterial peptides. The second version of our database (APD2) allows users to search peptide families (e.g. bacteriocins, cyclotides, or defensins), peptide sources (e.g. fish, frogs or chicken), post-translationally modified peptides (e.g. amidation, oxidation, lipidation, glycosylation or d-amino acids), and peptide binding targets (e.g. membranes, proteins, DNA/RNA, LPS or sugars). Statistical analyses reveal that the frequently used amino acid residues (>10%) are Ala and Gly in bacterial peptides, Cys and Gly in plant peptides, Ala, Gly and Lys in insect peptides, and Leu, Ala, Gly and Lys in amphibian peptides. Using frequently occurring residues, we demonstrate database-aided peptide design in different ways. Among the three peptides designed, GLK-19 showed a higher activity against Escherichia coli than human LL-37.
895 citations
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TL;DR: An antimicrobial peptide database (APD) has been established based on an extensive literature search and contains detailed information for 525 peptides (498 antibacterial, 155 antifungal, 28 antiviral and 18 antitumor).
Abstract: An antimicrobial peptide database (APD) has been established based on an extensive literature search. It contains detailed information for 525 peptides (498 antibacterial, 155 antifungal, 28 antiviral and 18 antitumor). APD provides interactive interfaces for peptide query, prediction and design. It also provides statistical data for a select group of or all the peptides in the database. Peptide information can be searched using keywords such as peptide name, ID, length, net charge, hydrophobic percentage, key residue, unique sequence motif, structure and activity. APD is a useful tool for studying the structure-function relationship of antimicrobial peptides. The database can be accessed via a web-based browser at the URL: http://aps.unmc.edu/AP/main.html.
771 citations
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TL;DR: Important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications, including bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered.
Abstract: Click chemistry refers to a group of reactions that are fast, simple to use, easy to purify, versatile, regiospecific, and give high product yields. While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. In this manuscript, important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications. Bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered. Limitations of the reaction will also be discussed.
708 citations
Authors
Showing all 965 results
Name | H-index | Papers | Citations |
---|---|---|---|
Maneesh Jain | 40 | 93 | 8619 |
Apar Kishor Ganti | 39 | 241 | 6378 |
Ming Fong Lin | 39 | 82 | 5024 |
James E. Talmadge | 39 | 165 | 4504 |
Diane F. Birt | 38 | 141 | 6103 |
Nicolas Moniaux | 38 | 62 | 4122 |
David T. Purtilo | 37 | 119 | 4685 |
Murielle Mimeault | 37 | 67 | 4601 |
Thomas Bechtold | 37 | 289 | 5175 |
Rodney D. McComb | 37 | 88 | 4746 |
Moorthy P. Ponnusamy | 36 | 98 | 3695 |
Keith R. Johnson | 36 | 59 | 5453 |
Dong Wang | 36 | 88 | 4007 |
Luis A. Marky | 35 | 115 | 5682 |
Daryl J. Murry | 35 | 121 | 4089 |