Institution
International Agency for Research on Cancer
Government•Lyon, France•
About: International Agency for Research on Cancer is a government organization based out in Lyon, France. It is known for research contribution in the topics: Cancer & Population. The organization has 2989 authors who have published 9010 publications receiving 929752 citations. The organization is also known as: IARC.
Topics: Cancer, Population, Breast cancer, Risk factor, European Prospective Investigation into Cancer and Nutrition
Papers published on a yearly basis
Papers
More filters
TL;DR: The continuing rise in lung cancer among women in many countries reinforces the need for targeted smoking cessation efforts alongside preventive actions.
308 citations
International Agency for Research on Cancer1, Russian Academy2, Nofer Institute of Occupational Medicine3, Curie Institute4, Charles University in Prague5, National and Kapodistrian University of Athens6, Harvard University7, Institut Gustave Roussy8, University of Bremen9, University of Turin10, University of Aberdeen11, University of Padua12, Imperial College London13, Newcastle University14, Glasgow Dental Hospital and School15, National Health Service16, Trinity College, Dublin17, Oswaldo Cruz Foundation18, Universidade Federal de Pelotas19, University of São Paulo20, Catholic University of the Sacred Heart21, University of North Carolina at Chapel Hill22, Pomeranian Medical University23, Fred Hutchinson Cancer Research Center24, Pennsylvania State University25, University of California, Los Angeles26, University of Texas MD Anderson Cancer Center27, Brown University28, Boston University29, University of Minnesota30, University of Pittsburgh31, Maastricht University32, Radboud University Nijmegen33, University of Toronto34, Cancer Care Ontario35, Norwegian University of Science and Technology36, University of Liverpool37, University of Naples Federico II38, University of Cambridge39, University of Oxford40, Utrecht University41, German Cancer Research Center42, Umeå University43, Aarhus University44, University Hospital of North Norway45, University of Tartu46, University of Paris47, New York University48
TL;DR: A genome-wide association study to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
308 citations
TL;DR: If one aim of a study is to detect interactions, the size of the study will have to be at least four times larger than if attention were confined to detecting main effects of the same magnitude.
Abstract: This paper considers quantitatively the extent to which the interaction or confounding effects of covariates may influence the design of case-control studies with particular reference to sample requirements and the role of matching. For the most part, attention is confined to a dichotomous exposure variable, and a single dichotomous covariate. Adjustment for confounding variables appears to have little effect on the power of a study unless they are strongly (odds ratio of 5 or more) related to both the disease and the exposure of interest, and only in similar circumstances will matching be of appreciable value. Matching also makes only a small improvement in the power to detect interaction effects, except under fairly extreme conditions. Both to control confounding and to detect interaction, the effect of matching may sometimes be to reduce the power of a study. The difference in power between matched and unmatched studies diminishes rapidly as the control-to-case ratio is increased. The implications of interaction effects for sample size requirements are more important. If one aim of a study is to detect interactions, the size of the study will have to be at least four times larger than if attention were confined to detecting main effects of the same magnitude. These conclusions are based on a quantitative evaluation of a wide range of possible situations.
307 citations
TL;DR: The Northern Sweden FFQ measurements have good reproducibility and an estimated level of validity similar to that ofFFQ measurements in other prospective cohort studies, and indicate that relative risk estimates corresponding to an absolute difference in dietary intake levels measured by the FFQ will generally be biased towards 1.0.
Abstract: OBJECTIVES: To evaluate the reproducibility of, and to compare and calibrate, diet measures by the Northern Sweden 84-item food-frequency questionnaire (FFQ) with measures from 24-hour diet recalls ...
307 citations
TL;DR: It can be concluded that, among HPV positive women, high parity, long-term OC use, smoking, and co-infection with other sexually transmitted agents are the most consistently identified environmental co-factors likely to influence the risk of progression from cervical HPV infection to HSIL and invasive CC.
307 citations
Authors
Showing all 3012 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David J. Hunter | 213 | 1836 | 207050 |
| Kay-Tee Khaw | 174 | 1389 | 138782 |
| Elio Riboli | 158 | 1136 | 110499 |
| Silvia Franceschi | 155 | 1340 | 112504 |
| Stephen J. Chanock | 154 | 1220 | 119390 |
| Paolo Boffetta | 148 | 1455 | 93876 |
| Timothy J. Key | 146 | 808 | 90810 |
| Hans-Olov Adami | 145 | 908 | 83473 |
| Joseph J.Y. Sung | 142 | 1240 | 92035 |
| Heiner Boeing | 140 | 1024 | 92580 |
| Anne Tjønneland | 139 | 1345 | 91556 |
| Kim Overvad | 139 | 1196 | 86018 |
| Sheila Bingham | 136 | 519 | 67332 |
| Pasi A. Jänne | 136 | 685 | 89488 |
| Peter Kraft | 135 | 821 | 82116 |