Islamic Azad University North Tehran Branch

About: Islamic Azad University North Tehran Branch is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Adsorption & Catalysis. The organization has 868 authors who have published 968 publications receiving 9987 citations.

Study of antimutagenic and anticancer effect of lactic acid bacteria isolated from Tarkhineh by Ames Test

Abstract: Background: Deaths due to cancer have been increasing in many countries in recent years. Probiotics are live microorganisms that have beneficial effects on consumer’s health. The aim of this study was to investigate antimutagenic and anticancer effects of Lactobacilli strains isolated from Tarkhineh in order to select potential probiotic strains. Materials and Methods: In this experimental study, 25 strains of Lactobacillus that had previously been isolated from Tarkhineh were used. Antimutagenicity test was performed based on proposed method of Ames. The results of the test were individuated after comparison between samples (suspensions of Lactobacilli) and positive (sodium azide) and negative (distilled water) controls. SPSS version 16 was used for statistical analysis. Results: Antimutagenic activity was observed only in four strains of Lactobacilli. The inhibitory percentage in the four strains of Lactobacilli, in its highest level was equal to 60.38 and in its lowest percentage equal to 39.37%. Also, the inhibitory percentage of mutation among the four strains in the presence of microsome were significantly different (P<0.05) than the absence of microsome. Adding the microsome of rat liver (S9) proved the anticancer effects of four Lactobacilli strains. Conclusion: Of the 25 strains of Lactobacilli, 4 strains which had the highest antimutagenicity

The H+ ions and static electric field effects on the adsorption and detection of cyanogen fluoride on the surface of boron nitride nanocage: a DFT, TD-DFT study

Abstract: By using the DFT and TD-DFT method, the potential of B12N12 nanocage to adsorb and detect of cyanogen fluoride (FCN) as a toxic gas molecule in the present of 1H+, 2H+, and 3H+ ions field and static electric field (SEF) were investigated at the WB97XD level of theory at the 6-31G (d, p) basis set. The structural and electrical parameters, adsorption energy, quantum descriptor, quantum theory of atom in the molecule (QTAIM), reduced density gradient (RDG), nonlinear optical properties (NLO), UV–Visible transitions, and thermodynamic parameters were calculated and results were analyzed. The adsorption energy (Eads), Enthalpy (ΔH) and Gibbs free energy (ΔG) values for all adsorption models were negative, and adsorption of FCN on the B12N12 nanocage was exothermic in the thermodynamic approach. The bandgap energy of all adsorption models is in the range of 7.60–11.08 eV, and with increasing the H+ ions functionalized and SEF, the bandgap energy of FCN/B12N12 complex decreased significantly from the pristine model, and so the conductivity and sensitivity of nanocluster increased. The QTAIM, ELF, LOL, and RDG results demonstrated that the attractive interaction between FCN and B12N12 in all models was a strong covalent bond. The NLO results revealed that the 3H+ functionalized B12N12 in presence of FCN was optically active. On the other hand, the calculated results demonstrated that the B12N12 nanocluster in the presence of 700 × 10−3 a.u electrostatic field (SEF0.70-z) and functionalizing 3H+ ions was a good strategy for adsorbing and making a sensitive sensor for FCN toxic gas.

Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats

Abstract: Numerous studies have reported that epilepsy causes memory deficits. The present study was aimed at studying the effect of rapamycin against the memory deficiency of the pentylenetetrazole (PTZ)-kindled animal model of epilepsy. In the present experiment, we randomly chose thirty male rats from the species of Wistar and categorized them in groups of control and experiment (6 for each group). The groups of experiment received the injection of rapamycin (0.5, 1 and 2 mg/kg) intraperitoneally (i.p.) and the group of control received normal saline (0.9%) treatment. Through the PTZ’s sub-threshold dose (35 mg kg−1, i.p.), all groups were kindled 12 times. Passive avoidance test (PAT) was used for gauging the memory function and the seizure behaviors after the kindling procedure. The rodents were sacrificed at the end of the trial and their brains were scooped for measuring the expression of Gabra1 and Pras40 genes. Statistical analysis unveiled that rapamycin delayed the kindling development and the onset of seizures which are tonic-clonic. Moreover, the administration of rapamycin significantly prevented memory dysfunction in epileptic rats. Finally, it was shown that rapamycin resulted in an increase in the expression levels of Gabra1 and Pras40 genes at the brain tissues. The current research design indicated that rapamycin has beneficial effects for the prevention of memory impairment against PTZ-kindling epilepsy in rats. Such promising outcomes could be attributed to its impact on the Gabra1 and Pras40 genes.