Khulna Medical College

About: Khulna Medical College is a healthcare organization based out in Khulna, Bangladesh. It is known for research contribution in the topics: Hysterectomy & Cancer. The organization has 266 authors who have published 203 publications receiving 964 citations. The organization is also known as: Khulna Medical College, Khulna & KMC.

Comparative study between Silodosin alone and Silodosin plus Tadalafil for the medical management of lower Ureteric Stone in South-Western part of the Bangladesh

Abstract: Objective: To compare the treatment outcome of Silodosin alone and Silodosin plusTadalafil as a medical expulsive therapy (MET) of lower ureteric stone in south-westernpart of Bangladesh. Methodology: The study was conducted in a tertiary hospital in Khulna, over a periodof 12 months (January 2019 to December 2019). Out of 108 patients, 100 meet theinclusion criteria who were purposively assigned into 2 groups. 48 patients included inSilodosin alone group and 52 in Silodosin plus Tadalafil group. Result: There was a significant higher stone expulsion rate in Silodosin plus Tadalafilthan Silodosin alone which was 88.46% vs75% respectively (P value 0.02). The meanstone expulsion time of Silodosin alone was14.33 (±3.1) days and Silodosin plus Tadalafilwas 11.48(±2.3) days (P value 0.001). The episodes of pain in Silodosin alone were0.7(±0.06) and 0.6(±0.2) in Silodosin plus Tadalafil group that was statisticallysignificant. Conclusion: The present study concludes that Silodosin plus tadalafil combinationtherapy significantly increases ureteric stone expulsion rate and decreases the expulsiontime and pain episodes than treatment with silodosin alone. Bangladesh Journal of Urology, Vol. 23, No. 1, January 2020 p.67-71

Metastatic male breast cancer

Abstract: Breast cancer of female is common but rare in male. It is diagnosed in advanced stage due to the limited amount of breast tissue and lack of awareness. Most cases occur over the age of 60 years. Male breast cancer is treated like female breast cancer. The outcome of the disease is worse, 5-4 year’s survival in about 40% cases. Mediscope Vol. 2, No. 1: 2015, Pages 36-38

Safety of non-descent vaginal hysterectomy

Abstract: The aim of our study is exploring the safety and feasibility of nondescent vaginal hysterectomy in benign diseases of uterus and also maximizing the proportion of hysterectomy performed vaginally. This was a prospective descriptive study done in obstetrics and gynaecology department of Khulna medical college hospital and two private clinic in Khulna and Satkhira. Over a period of 3 years from January 2012 to December 2014, a total of 56 cases underwent hysterectomy done vaginally for benign diseases. The most common age group affected was 41-50 years (64.28%) and second common group was below 40 years. Majority (73.21%) of the patients was multiparas and 6 weeks size affected uterus was 41.07%. Most common indication for NDVH was dysfiinctional uterine bleeding (39.29%) and fibroid uterus was 35.71%. Among 56 patients 25 cases needed dcbulking technique (44.64%) of which bisection was 32.14%. Maximum (53.57%) operation was completed within 61 to 90 minutes. Maximum blood loss of 201 ml or more was in 3 cases but only 5 patients needed blood transfusion. Among 56 patients. 5 (8.92%) patients suffered from various forms of complications but urinary fistula was nil. So it can be concluded that non descent vaginal hysterectomy has many advantages which include short hospital stay and fast convalescence. Bang Med J (Khulna) 2015; 48 : 16-19

Is There any Association Between CagA+ H. Pylori Infection and Histopathological Types of Gastric Carcinoma

Abstract: Enormous studies have been conducted worldwide regarding CagA+ status of H. pylori in gastric carcinoma. But no study relating CagA+ status and gastric carcinoma has been carried out in our country yet. Thus, this study has been designed to see the association between CagA+ H. Pylori infection and histopathological types of gastric carcinoma. For this purpose, a total number of 80 (eighty) patients were selected. Of the 80 (eighty) patients 40 (forty) were selected as cases (malignant) and the remainder 40 (forty) were selected as controls (non-malignant). H. pylori was detected by applying non-invasive (H. pylori IgG serology and CagA IgG serology) and invasive (Histology and rapid urease test) technique. Of them Histology was done by Modified giemsa stain which was regarded as gold standard, CagA IgG was detected by ELISA method. Study reveals that there is no significant difference between histologic sub-types (Intestinal vs. Diffuse) of gastric carcinoma in relation with H. pylori positivity and present study also shows that there is no significant difference among the sites of lesion regarding H. pylori positivity. In this study, we see that among the 40 cases, 35(thirty five) possess the CagA+ H. pylori strain. And among the 40 controls, 33(thirty three) bear the CagA+ H. pylori strain. Here case-control difference is insignificant regarding CagA IgG status.The present study supports the view of an association of H. pylori infection with both intestinal and diffuse types of gastric cancer. It may be possible that H. pylori may be causally related to both forms of gastriccancer via unknown mechanism or this finding may be due to small sample size. In this study, no significant difference between case and control on the point of CagA IgG status was found. There are sufficient papers in favor of it-which argues that CagA positivity as well as H. pylori positivity is not the sole causative agent of gastric carcinoma. If so,it merely acts as an initiator.However,it is being left open for the future researchers to prove or to disprove it. Medicine Today 2010 Volume 22 Number 02 Page 62-69 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12435