Institution
Leibniz Association
Government•Berlin, Germany•
About: Leibniz Association is a government organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 16586 authors who have published 35691 publications receiving 1095107 citations. The organization is also known as: Leibniz-Gemeinschaft & Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz.
Topics: Population, Gene, Aerosol, Catalysis, Genome
Papers published on a yearly basis
Papers
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TL;DR: This review deals with the reconstruction of gene regulatory networks (GRNs) from experimental data through computational methods and approaches are discussed that enable the modelling of the dynamics of Gene regulatory systems.
Abstract: Systems biology aims to develop mathematical models of biological systems by integrating experimental and theoretical techniques. During the last decade, many systems biological approaches that base on genome-wide data have been developed to unravel the complexity of gene regulation. This review deals with the reconstruction of gene regulatory networks (GRNs) from experimental data through computational methods. Standard GRN inference methods primarily use gene expression data derived from microarrays. However, the incorporation of additional information from heterogeneous data sources, e.g. genome sequence and protein-DNA interaction data, clearly supports the network inference process. This review focuses on promising modelling approaches that use such diverse types of molecular biological information. In particular, approaches are discussed that enable the modelling of the dynamics of gene regulatory systems. The review provides an overview of common modelling schemes and learning algorithms and outlines current challenges in GRN modelling.
742 citations
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Goethe University Frankfurt1, CERN2, University of Helsinki3, Paul Scherrer Institute4, University of Beira Interior5, University of Innsbruck6, Carnegie Mellon University7, California Institute of Technology8, University of Leeds9, University of Eastern Finland10, University of Vienna11, Lebedev Physical Institute12, Finnish Meteorological Institute13, Kyoto University14, Helsinki Institute of Physics15, Stockholm University16, Leibniz Association17
TL;DR: The results show that, in regions of the atmosphere near amine sources, both amines and sulphur dioxide should be considered when assessing the impact of anthropogenic activities on particle formation.
Abstract: Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei(1). Aerosols can cause a net cooling of climate by scattering sun ...
738 citations
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TL;DR: An overview of the key features of CT and CS membranes and scaffolds such as their biodegradability, cytocompatibility and mechanical properties toward applications in tissue engineering and wound healing are provided.
732 citations
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TL;DR: It is proposed that two pathological hits, namely nuclear import defects and cellular stress, are involved in the pathogenesis of FUS‐opathies.
Abstract: Mutations in fused in sarcoma (FUS) are a cause of familial amyotrophic lateral sclerosis (fALS). Patients carrying point mutations in the C-terminus of FUS show neuronal cytoplasmic FUS-positive inclusions, whereas in healthy controls, FUS is predominantly nuclear. Cytoplasmic FUS inclusions have also been identified in a subset of frontotemporal lobar degeneration (FTLD-FUS). We show that a non-classical PY nuclear localization signal (NLS) in the C-terminus of FUS is necessary for nuclear import. The majority of fALS-associated mutations occur within the NLS and impair nuclear import to a degree that correlates with the age of disease onset. This presents the first case of disease-causing mutations within a PY-NLS. Nuclear import of FUS is dependent on Transportin, and interference with this transport pathway leads to cytoplasmic redistribution and recruitment of FUS into stress granules. Moreover, proteins known to be stress granule markers co-deposit with inclusions in fALS and FTLD-FUS patients, implicating stress granule formation in the pathogenesis of these diseases. We propose that two pathological hits, namely nuclear import defects and cellular stress, are involved in the pathogenesis of FUS-opathies.
728 citations
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TL;DR: The results provide the first analysis of the global conservation status and distribution patterns of reptiles and the threats affecting them, highlighting conservation priorities and knowledge gaps which need to be addressed urgently to ensure the continued survival of the world’s reptiles.
720 citations
Authors
Showing all 16595 results
Name | H-index | Papers | Citations |
---|---|---|---|
Helmut Sies | 133 | 670 | 78319 |
Mark Stitt | 132 | 456 | 60800 |
Norbert Schwarz | 117 | 488 | 71008 |
Matthias Beller | 113 | 733 | 46344 |
Matthias Steinmetz | 112 | 461 | 67802 |
Marten Scheffer | 111 | 350 | 73789 |
Erko Stackebrandt | 106 | 633 | 68201 |
Andreas Radbruch | 104 | 485 | 36872 |
Rajeev K. Varshney | 102 | 709 | 39796 |
Thomas J. Jentsch | 101 | 238 | 32810 |
Michael Schulz | 100 | 759 | 50719 |
Oliver G. Schmidt | 100 | 1083 | 39988 |
Rainer Waser | 99 | 927 | 48315 |
Paul Knochel | 99 | 2373 | 44786 |
Matthias Beller | 97 | 903 | 34480 |