Massachusetts Institute of Technology

About: Massachusetts Institute of Technology is a education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Laser. The organization has 116795 authors who have published 268000 publications receiving 18272025 citations. The organization is also known as: MIT & M.I.T..

Spatial Planning: A Configuration Space Approach

Abstract: This paper presents algorithms for computing constraints on the position of an object due to the presence of ther objects. This problem arises in applications that require choosing how to arrange or how to move objects without collisions. The approach presented here is based on characterizing the position and orientation of an object as a single point in a configuration space, in which each coordinate represents a degree of freedom in the position or orientation of the object. The configurations forbidden to this object, due to the presence of other objects, can then be characterized as regions in the configuration space, called configuration space obstacles. The paper presents algorithms for computing these configuration space obstacles when the objects are polygons or polyhedra.

Self-Organization of CdSe Nanocrystallites into Three-Dimensional Quantum Dot Superlattices

Abstract: The self-organization of CdSe nanocrystallites into three-dimensional semiconductor quantum dot superlattices (colloidal crystals) is demonstrated. The size and spacing of the dots within the superlattice are controlled with near atomic precision. This control is a result of synthetic advances that provide CdSe nanocrystallites that are monodisperse within the limit of atomic roughness. The methodology is not limited to semiconductor quantum dots but provides general procedures for the preparation and characterization of ordered structures of nanocrystallites from a variety of materials.

Representing and testing organizational theories: A holistic construal.

Abstract: This research was supported by a Senior Fulbright Research Grant to R. P. Bagozzi and a grant to L. W. Phillips from the Distribution Research and Educational Foundation (DREF), National Association of Wholesale Distributors, Washington, DC. Special thanks go to Dirk Van Dongen, Executive Director of DREF, and Ron Schreibman, Director of Research, for their assistance throughout the project. The contributions made to the research by Louis W. Stern, Northwestern University, are gratefully acknowledged. Comments on an earlier draft by Claes Fornell, University of Michigan, Barbara Lawrence and Alvin Silk, MIT, and V. Srinivasan and Jeffrey Pfeffer, Stanford University, also contributed to ideas presented in this paper, as did suggestions made by the editors. A holistic construal is presented to represent and test organizational theories, using examples from contemporary organizational theory and data from a recent study of wholesale distribution companies. The methodology provides a mechanism for linking theory construction and theory testing in organization research by explicitly representing theoretical and empirical concepts, nonobservational hypotheses, and correspondence rules. Unlike traditional methods used for construct validation and hypothesis testing, the methodology permits the researcher to model the extent of random and systematic error in measures of theoretical concepts and to control these sources of error when testing substantive hypotheses. Comparisons made between the holistic construal and traditional procedures show how the latter can lead to inaccurate conclusions about the status of a theory's constructs, hypotheses, and measures.

Rationally Engineered Cas9 Nucleases With Improved Specificity

Abstract: The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes. Cas9 creates double-strand breaks (DSBs) at targeted genomic loci complementary to a short RNA guide. However, Cas9 can cleave off-target sites that are not fully complementary to the guide, which poses a major challenge for genome editing. Here, we use structure-guided protein engineering to improve the specificity of Streptococcus pyogenes Cas9 (SpCas9). Using targeted deep sequencing and unbiased whole-genome off-target analysis to assess Cas9-mediated DNA cleavage in human cells, we demonstrate that "enhanced specificity" SpCas9 (eSpCas9) variants reduce off-target effects and maintain robust on-target cleavage. Thus, eSpCas9 could be broadly useful for genome-editing applications requiring a high level of specificity.

An analytic derivation of the cost of deposit insurance and loan guarantees An application of modern option pricing theory

Abstract: It is not uncommon in the arrangement of a loan to include as part of the financial package a guarantee of the loan by a third party. Examples are guarantees by a parent company of loans made to its subsidiaries or government guarantees of loans made to private corporations. Also included would be guarantees of bank deposits by the Federal Deposit Insurance Corporation. As with other forms of insurance, the issuing of a guarantee imposes a liability or cost on the guarantor. In this paper, a formula is derived to evaluate this cost. The method used is to demonstrate an isomorphic correspondence between loan guarantees and common stock put options, and then to use the well developed theory of option pricing to derive the formula.