Massachusetts Institute of Technology

About: Massachusetts Institute of Technology is a education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Laser. The organization has 116795 authors who have published 268000 publications receiving 18272025 citations. The organization is also known as: MIT & M.I.T..

Impossibility of distributed consensus with one faulty process

Abstract: The consensus problem involves an asynchronous system of processes, some of which may be unreliable The problem is for the reliable processes to agree on a binary value In this paper, it is shown that every protocol for this problem has the possibility of nontermination, even with only one faulty process By way of contrast, solutions are known for the synchronous case, the “Byzantine Generals” problem

Distributed space-time-coded protocols for exploiting cooperative diversity in wireless networks

Abstract: We develop and analyze space-time coded cooperative diversity protocols for combating multipath fading across multiple protocol layers in a wireless network. The protocols exploit spatial diversity available among a collection of distributed terminals that relay messages for one another in such a manner that the destination terminal can average the fading, even though it is unknown a priori which terminals will be involved. In particular, a source initiates transmission to its destination, and many relays potentially receive the transmission. Those terminals that can fully decode the transmission utilize a space-time code to cooperatively relay to the destination. We demonstrate that these protocols achieve full spatial diversity in the number of cooperating terminals, not just the number of decoding relays, and can be used effectively for higher spectral efficiencies than repetition-based schemes. We discuss issues related to space-time code design for these protocols, emphasizing codes that readily allow for appealing distributed versions.

Mosaic organization of DNA nucleotides

Abstract: Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions We address the question of whether such correlations may be a trivial consequence of the known mosaic structure ("patchiness") of DNA We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range power-law correlations Although both types of sequences are highly heterogenous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties

Adaptive mixtures of local experts

Abstract: We present a new supervised learning procedure for systems composed of many separate networks, each of which learns to handle a subset of the complete set of training cases. The new procedure can be viewed either as a modular version of a multilayer supervised network, or as an associative version of competitive learning. It therefore provides a new link between these two apparently different approaches. We demonstrate that the learning procedure divides up a vowel discrimination task into appropriate subtasks, each of which can be solved by a very simple expert network.

Guidelines for the use and interpretation of assays for monitoring autophagy

Abstract: In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.