Massachusetts Institute of Technology

About: Massachusetts Institute of Technology is a education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Laser. The organization has 116795 authors who have published 268000 publications receiving 18272025 citations. The organization is also known as: MIT & M.I.T..

The Role of Product Architecture in the Manufacturing Firm

Abstract: Product architecture is the scheme by which the function of a product is allocated to physical components. This paper further defines product architecture, provides a typology of product architectures, and articulates the potential linkages between the architecture of the product and five areas of managerial importance: (1) product change; (2) product variety; (3) component standardization; (4) product performance; and (5) product development management. The paper is conceptual and foundational, synthesizing fragments from several different disciplines, including software engineering, design theory, operations management and product development management. The paper is intended to raise awareness of the far-reaching implications of the architecture of the product, to create a vocabulary for discussing and addressing the decisions and issues that are linked to product architecture, and to identify and discuss specific trade-offs associated with the choice of a product architecture.

The click modular router

Abstract: Clicks is a new software architecture for building flexible and configurable routers. A Click router is assembled from packet processing modules called elements. Individual elements implement simple router functions like packet classification, queuing, scheduling, and interfacing with network devices. A router configurable is a directed graph with elements at the vertices; packets flow along the edges of the graph. Several features make individual elements more powerful and complex configurations easier to write, including pull connections, which model packet flow drivn by transmitting hardware devices, and flow-based router context, which helps an element locate other interesting elements. Click configurations are modular and easy to extend. A standards-compliant Click IP router has 16 elements on its forwarding path; some of its elements are also useful in Ethernet switches and IP tunnelling configurations. Extending the IP router to support dropping policies, fairness among flows, or Differentiated Services simply requires adding a couple of element at the right place. On conventional PC hardware, the Click IP router achieves a maximum loss-free forwarding rate of 333,000 64-byte packets per second, demonstrating that Click's modular and flexible architecture is compatible with good performance.

Transdermal drug delivery

Abstract: Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, noncavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase its impact on medicine.