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Institution

Massachusetts Institute of Technology

EducationCambridge, Massachusetts, United States
About: Massachusetts Institute of Technology is a education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Laser. The organization has 116795 authors who have published 268000 publications receiving 18272025 citations. The organization is also known as: MIT & M.I.T..


Papers
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Journal ArticleDOI
12 May 1995-Science
TL;DR: Cortical magnification factor curves for striate and extrastriate cortical areas were determined, which showed that human visual areas have a greater emphasis on the center-of-gaze than their counterparts in monkeys.
Abstract: The borders of human visual areas V1, V2, VP, V3, and V4 were precisely and noninvasively determined. Functional magnetic resonance images were recorded during phase-encoded retinal stimulation. This volume data set was then sampled with a cortical surface reconstruction, making it possible to calculate the local visual field sign (mirror image versus non-mirror image representation). This method automatically and objectively outlines area borders because adjacent areas often have the opposite field sign. Cortical magnification factor curves for striate and extrastriate cortical areas were determined, which showed that human visual areas have a greater emphasis on the center-of-gaze than their counterparts in monkeys. Retinotopically organized visual areas in humans extend anteriorly to overlap several areas previously shown to be activated by written words.

2,590 citations

Journal ArticleDOI
Kazunori Akiyama, Antxon Alberdi1, Walter Alef2, Keiichi Asada3  +403 moreInstitutions (82)
TL;DR: In this article, the Event Horizon Telescope was used to reconstruct event-horizon-scale images of the supermassive black hole candidate in the center of the giant elliptical galaxy M87.
Abstract: When surrounded by a transparent emission region, black holes are expected to reveal a dark shadow caused by gravitational light bending and photon capture at the event horizon. To image and study this phenomenon, we have assembled the Event Horizon Telescope, a global very long baseline interferometry array observing at a wavelength of 1.3 mm. This allows us to reconstruct event-horizon-scale images of the supermassive black hole candidate in the center of the giant elliptical galaxy M87. We have resolved the central compact radio source as an asymmetric bright emission ring with a diameter of 42 +/- 3 mu as, which is circular and encompasses a central depression in brightness with a flux ratio greater than or similar to 10: 1. The emission ring is recovered using different calibration and imaging schemes, with its diameter and width remaining stable over four different observations carried out in different days. Overall, the observed image is consistent with expectations for the shadow of a Kerr black hole as predicted by general relativity. The asymmetry in brightness in the ring can be explained in terms of relativistic beaming of the emission from a plasma rotating close to the speed of light around a black hole. We compare our images to an extensive library of ray-traced general-relativistic magnetohydrodynamic simulations of black holes and derive a central mass of M = (6.5 +/- 0.7) x 10(9) M-circle dot. Our radio-wave observations thus provide powerful evidence for the presence of supermassive black holes in centers of galaxies and as the central engines of active galactic nuclei. They also present a new tool to explore gravity in its most extreme limit and on a mass scale that was so far not accessible.

2,589 citations

Journal ArticleDOI
19 Nov 1993-Cell
TL;DR: It is proposed that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteINE proteases also function in programmed cell deaths in mammals.

2,587 citations

Journal ArticleDOI
TL;DR: In this article, the authors consider the problem of central control in a large economic organization, where the basic operating rules from the centre take the form of quotas, targets, or commands to produce a certain level of output.
Abstract: The setting for the problem under consideration is a large economic organization or system which in some cases is best thought of as the entire economy. Within this large economic organization resources are allocated by some combination of commands and prices (the exact mixture is inessential) or even by some other unspecified mechanism. The following question arises. For one particular isolated economic variable that needs to be regulated,3 what is the best way to implement control for the benefit of the organization as a whole? Is it better to directly administer the activity under scrutiny or to fix transfer prices and rely on self-interested profit or utility maximization to achieve the same ends in decentralized fashion? This issue is taken as the prototype problem of central control which is studied in the present paper. There are a great many specific examples which fit nicely into such a framework. One of current interest is the question of whether it would be better to control certain forms of pollution by setting emission standards or by charging the appropriate pollution taxes. When quantities are employed as planning instruments, the basic operating rules from the centre take the form of quotas, targets, or commands to produce a certain level of output. With prices as instruments, the rules specify either explicitly or implicitly that profits are to be maximized at the given parametric prices. Now a basic theme of resource allocation theory emphasizes the close connection between these two modes of control. No matter how one type of planning instrument is fixed, there is always a corresponding way to set the other which achieves the same result when implemented.4 From a strictly theoretical point of view there is really nothing to recommend one mode of control over the other. This notwithstanding, I think it is a fair generalization to say that the average economist in the Western marginalist tradition has at least a vague preference toward indirect control by prices, just as the typical non-economist leans toward the direct regulation of quantities. That a person not versed in economics should think primarily in terms of direct controls is probably due to the fact that he does not comprehend the full subtlety and strength of the invisible hand argument. The economist's attitude is somewhat more puzzling. Understanding that prices can be used as a powerful and flexible instrument for rationally allocating resources and that in fact a market economy automatically regulates itself in this manner is very different from being under the impression that such indirect controls are generally preferable for the kind of problem considered in this paper. Certainly a careful reading of economic theory yields little to support such a universal proposition.

2,585 citations


Authors

Showing all 117442 results

NameH-indexPapersCitations
Eric S. Lander301826525976
Robert Langer2812324326306
George M. Whitesides2401739269833
Trevor W. Robbins2311137164437
George Davey Smith2242540248373
Yi Cui2201015199725
Robert J. Lefkowitz214860147995
David J. Hunter2131836207050
Daniel Levy212933194778
Rudolf Jaenisch206606178436
Mark J. Daly204763304452
David Miller2032573204840
David Baltimore203876162955
Rakesh K. Jain2001467177727
Ronald M. Evans199708166722
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023240
20221,124
202110,595
202011,922
201911,207
201810,883