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Institution

Massachusetts Institute of Technology

EducationCambridge, Massachusetts, United States
About: Massachusetts Institute of Technology is a education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Laser. The organization has 116795 authors who have published 268000 publications receiving 18272025 citations. The organization is also known as: MIT & M.I.T..


Papers
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Journal ArticleDOI
22 Aug 2008-Science
TL;DR: A catalyst that forms upon the oxidative polarization of an inert indium tin oxide electrode in phosphate-buffered water containing cobalt (II) ions is reported that not only forms in situ from earth-abundant materials but also operates in neutral water under ambient conditions.
Abstract: The utilization of solar energy on a large scale requires its storage. In natural photosynthesis, energy from sunlight is used to rearrange the bonds of water to oxygen and hydrogen equivalents. The realization of artificial systems that perform "water splitting" requires catalysts that produce oxygen from water without the need for excessive driving potentials. Here we report such a catalyst that forms upon the oxidative polarization of an inert indium tin oxide electrode in phosphate-buffered water containing cobalt (II) ions. A variety of analytical techniques indicates the presence of phosphate in an approximate 1:2 ratio with cobalt in this material. The pH dependence of the catalytic activity also implicates the hydrogen phosphate ion as the proton acceptor in the oxygen-producing reaction. This catalyst not only forms in situ from earth-abundant materials but also operates in neutral water under ambient conditions.

3,695 citations

Proceedings ArticleDOI
22 Sep 1975
TL;DR: A data model, called the entity-relationship model, which incorporates the semantic information in the real world is proposed, and a special diagramatic technique is introduced for exhibiting entities and relationships.
Abstract: A data model, called the entity-relationship model, is proposed. This model incorporates some of the important semantic information about the real world. A special diagrammatic technique is introduced as a tool for database design. An example of database design and description using the model and the diagrammatic technique is given. Some implications for data integrity, information retrieval, and data manipulation are discussed.The entity-relationship model can be used as a basis for unification of different views of data: the network model, the relational model, and the entity set model. Semantic ambiguities in these models are analyzed. Possible ways to derive their views of data from the entity-relationship model are presented.

3,693 citations

Journal ArticleDOI
14 Apr 1983-Nature
TL;DR: In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome which are assembled by recombination which leads to the formation of a complete gene.
Abstract: In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.

3,679 citations

Journal ArticleDOI
TL;DR: In this paper, a method is described for converting a weak learning algorithm into one that achieves arbitrarily high accuracy, and it is shown that these two notions of learnability are equivalent.
Abstract: This paper addresses the problem of improving the accuracy of an hypothesis output by a learning algorithm in the distribution-free (PAC) learning model. A concept class is learnable (or strongly learnable) if, given access to a source of examples of the unknown concept, the learner with high probability is able to output an hypothesis that is correct on all but an arbitrarily small fraction of the instances. The concept class is weakly learnable if the learner can produce an hypothesis that performs only slightly better than random guessing. In this paper, it is shown that these two notions of learnability are equivalent. A method is described for converting a weak learning algorithm into one that achieves arbitrarily high accuracy. This construction may have practical applications as a tool for efficiently converting a mediocre learning algorithm into one that performs extremely well. In addition, the construction has some interesting theoretical consequences, including a set of general upper bounds on the complexity of any strong learning algorithm as a function of the allowed error e.

3,678 citations

Journal ArticleDOI
25 Jun 2004-Cell
TL;DR: A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).

3,670 citations


Authors

Showing all 117442 results

NameH-indexPapersCitations
Eric S. Lander301826525976
Robert Langer2812324326306
George M. Whitesides2401739269833
Trevor W. Robbins2311137164437
George Davey Smith2242540248373
Yi Cui2201015199725
Robert J. Lefkowitz214860147995
David J. Hunter2131836207050
Daniel Levy212933194778
Rudolf Jaenisch206606178436
Mark J. Daly204763304452
David Miller2032573204840
David Baltimore203876162955
Rakesh K. Jain2001467177727
Ronald M. Evans199708166722
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023240
20221,124
202110,595
202011,922
201911,207
201810,883