Institution
Medical University of Graz
Education•Graz, Steiermark, Austria•
About: Medical University of Graz is a education organization based out in Graz, Steiermark, Austria. It is known for research contribution in the topics: Population & Medicine. The organization has 5684 authors who have published 12349 publications receiving 417282 citations.
Topics: Population, Medicine, Cancer, Transplantation, Vitamin D and neurology
Papers published on a yearly basis
Papers
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TL;DR: The dysregulation of the growth factors and their receptors may be involved in placental and fetal changes observed in diabetes, i.e. enhanced placentaland fetal growth, placental hypervascularization and higher levels of fetal plasma amino acids.
Abstract: The insulin/insulin-like growth factor (IGF) system regulates fetal and placental growth and development. In maternal diabetes, components of this system including insulin, IGF1, IGF2 and various IGF-binding proteins are deregulated in the maternal or fetal circulation, or in the placenta. The placenta expresses considerable amounts of insulin and IGF1 receptors at distinct locations on both placental surfaces. This makes the insulin and the IGF1 receptor accessible to fetal and/or maternal insulin, IGF1 and IGF2. Unlike the receptor for IGF1, the insulin receptor undergoes a gestational change in expression site from the trophoblast at the beginning of pregnancy to the endothelium at term. Insulin and IGFs are implicated in the receptor-mediated regulation of placental growth and transport, trophoblast invasion and placental angiogenesis. The dysregulation of the growth factors and their receptors may be involved in placental and fetal changes observed in diabetes, i.e. enhanced placental and fetal growth, placental hypervascularization and higher levels of fetal plasma amino acids.
189 citations
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University of Rennes1, Radboud University Nijmegen Medical Centre2, McMaster University3, Charles University in Prague4, University of Regensburg5, Pierre-and-Marie-Curie University6, Queen Alexandra Hospital7, Autonomous University of Barcelona8, Netherlands Cancer Institute9, European Association of Urology10, Medical University of Graz11, Medical University of Vienna12
TL;DR: A systematic review of studies that compared kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma found similar oncologic outcomes for favourable tumours when using ureteroscopic or percutaneous management, whereas indications for segmental ureteretectomy could be extended to selected cases of aggressive tumours.
188 citations
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Medical University of Graz1, University of Birmingham2, Ludwig Maximilian University of Munich3, University of Gothenburg4, University of Debrecen5, University of Helsinki6, University of Hamburg7, University of Bonn8, John Radcliffe Hospital9, Karolinska University Hospital10, Oslo University Hospital11, Katholieke Universiteit Leuven12, Medical University of Vienna13, Hannover Medical School14
TL;DR: A side chain-shortened derivative of ursodeoxycholic acid, norursodexycholic Acid (norUDCA), significantly reduced serum alkaline phosphatase levels in a dose-dependent manner during a 12-week treatment and showed a favorable safety profile, which was similar to placebo.
188 citations
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Hannover Medical School1, Örebro University2, University College London3, Cairo University4, Ankara University5, Ghent University Hospital6, Ege University7, Karolinska University Hospital8, Karolinska Institutet9, Leipzig University10, Université de Montréal11, Universidade Federal do Estado do Rio de Janeiro12, Universidade Federal do Rio Grande do Sul13, Odense University Hospital14, Federal University of Rio de Janeiro15, University of Plymouth16, University of New South Wales17, Ain Shams University18, Dokuz Eylül University19, Federal University of São Paulo20, Carlos III Health Institute21, University of Copenhagen22, State University of Campinas23, University of São Paulo24, Medical University of Vienna25, Masaryk University26, University of Manitoba27, Istanbul University28, University of British Columbia29, Aalborg University30, Katholieke Universiteit Leuven31, University of Western Ontario32, University of Düsseldorf33, Université libre de Bruxelles34, University of Zurich35, University of Calgary36, Queen Elizabeth II Health Sciences Centre37, Monash University38, Nottingham University Hospitals NHS Trust39, Goethe University Frankfurt40, University of St. Gallen41, University Health Network42, Université catholique de Louvain43, Medical University of Graz44, University of Melbourne45, Charles University in Prague46, University of Antwerp47, University of Hasselt48, Copenhagen University Hospital49, Geneva College50
TL;DR: It is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030), however, for most countries presented, this will require a 3–5 fold increase in diagnosis and/or treatment.
Abstract: The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.
188 citations
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Medical University of Graz1, University of Naples Federico II2, University of Bari3, Universidade Federal do Rio Grande do Sul4, Claude Bernard University Lyon 15, Ente Ospedaliero Ospedali Galliera6, University of Buenos Aires7, National Autonomous University of Mexico8, University of Sydney9, Zhengzhou University10, Memorial Sloan Kettering Cancer Center11, Keio University12, Ege University13, Shinshu University14, University of Modena and Reggio Emilia15
TL;DR: Over the 10-year study period, accuracy in melanoma detection improved only in specialized clinics maybe because of a larger use of new diagnostic techniques such as dermatoscopy.
Abstract: Background Early excision is the only strategy to reduce melanoma mortality, but unnecessary excision of benign lesions increases morbidity and healthcare costs. Objective To assess accuracy in melanoma detection based on number-needed-to-excise (NNE) values over a 10-year period. Methods Information was retrieved on all histopathologically confirmed cutaneous melanomas or melanocytic nevi that were excised between 1998 and 2007 at participating clinics. NNE values were calculated by dividing the total number of excised lesions by the number of melanomas. Analyses included changes in NNE over time, differences in NNE between specialized clinical settings (SCS) versus non-specialized clinical settings (NSCS), and patient factors influencing NNE. Results The participating clinics contributed a total of 300,215 cases, including 17,172 melanomas and 283,043 melanocytic nevi. The overall NNE values achieved in SCS and NSCS in the 10-year period were 8.7 and 29.4, respectively. The NNE improved over time in SCS (from 12.8 to 6.8), but appeared unchanged in NSCS. Most of the effect on NNE in SCS was due to a greater number of excised melanomas. Higher NNE values were observed in patients younger than 40 years and for lesions located on the trunk. Limitations No data concerning the use of dermatoscopy and digital monitoring procedures were collected from the participating centers. Conclusion Over the 10-year study period, accuracy in melanoma detection improved only in specialized clinics maybe because of a larger use of new diagnostic techniques such as dermatoscopy.
186 citations
Authors
Showing all 5763 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ian J. Deary | 166 | 1795 | 114161 |
James F. Wilson | 146 | 677 | 101883 |
Nancy L. Pedersen | 145 | 890 | 94696 |
William Wijns | 127 | 752 | 95517 |
Andrew Simmons | 102 | 460 | 36608 |
Franz Fazekas | 101 | 629 | 49775 |
Hans-Peter Hartung | 100 | 810 | 49792 |
Michael Trauner | 98 | 667 | 35543 |
Dietmar Fuchs | 97 | 1119 | 39758 |
Funda Meric-Bernstam | 96 | 753 | 36803 |
Ulf Landmesser | 94 | 564 | 46096 |
Aysegul A. Sahin | 93 | 322 | 30038 |
Frank Madeo | 92 | 269 | 45942 |
Takayoshi Ohkubo | 91 | 631 | 69634 |
Jürgen C. Becker | 90 | 637 | 28741 |