Institution
Medical University of Graz
Education•Graz, Steiermark, Austria•
About: Medical University of Graz is a education organization based out in Graz, Steiermark, Austria. It is known for research contribution in the topics: Population & Medicine. The organization has 5684 authors who have published 12349 publications receiving 417282 citations.
Topics: Population, Medicine, Cancer, Transplantation, Vitamin D and neurology
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Dalhousie University1, Charité2, National Institutes of Health3, University of Geneva4, Karolinska Institutet5, State University of Campinas6, University of Adelaide7, University of Paris8, Medical University of Graz9, Mayo Clinic10, Academia Sinica11, University of Bonn12, University of Cagliari13, Johns Hopkins University14, French Institute of Health and Medical Research15, Ludwig Maximilian University of Munich16, Neuroscience Research Australia17, University of Toronto18, University of Göttingen19, Osaka University20, University of California, San Diego21, United States Department of Veterans Affairs22, University of Würzburg23, National Taiwan University24, Hokkaido University25, University of Antioquia26, University of Naples Federico II27, University of New South Wales28, Fujita Health University29, Nagoya University30, Harvard University31, Dresden University of Technology32, University of Iowa33, Université de Montréal34, University of Queensland35, Heidelberg University36
TL;DR: The key phenotypic measures of the “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” scale currently used in the Consortium on lithium Genetics (ConLiGen) study are reported.
Abstract: OBJECTIVE: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. MATERIALS AND METHODS: Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. RESULTS: Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). CONCLUSIONS: We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.
407 citations
University of Helsinki1, Maastricht University2, University of Texas Southwestern Medical Center3, Columbia University4, University of Gothenburg5, Concord Repatriation General Hospital6, University of Manitoba7, University of Bonn8, Medical University of Graz9, Heidelberg University10, University of Bern11, Lille University of Science and Technology12, University of Milan13, Ghent University14, University College London15, University of Naples Federico II16, Hacettepe University17, French Institute of Health and Medical Research18
TL;DR: Functional foods with plant sterols/stanols may be considered in individuals with high cholesterol levels at intermediate or low global cardiovascular risk who do not qualify for pharmacotherapy and as an adjunct to pharmacologic therapy in high and very high risk patients who fail to achieve LDL-C targets on statins or are statin- intolerant.
406 citations
TL;DR: The progress and challenges in the diagnosis of multiple sclerosis with reference to diagnostic criteria, important differential diagnoses, controversies and uncertainties, and future prospects are explored.
404 citations
TL;DR: How CTCs have contributed to significant insights into the metastatic process and how they may be utilized in clinical practice are reviewed.
Abstract: Metastasis is a biologically complex process consisting of numerous stochastic events which may tremendously differ across various cancer types. Circulating tumor cells (CTCs) are cells that are shed from primary tumors and metastatic deposits into the blood stream. CTCs bear a tremendous potential to improve our understanding of steps involved in the metastatic cascade, starting from intravasation of tumor cells into the circulation until the formation of clinically detectable metastasis. These efforts were propelled by novel high-resolution approaches to dissect the genomes and transcriptomes of CTCs. Furthermore, capturing of viable CTCs has paved the way for innovative culturing technologies to study fundamental characteristics of CTCs such as invasiveness, their kinetics and responses to selection barriers, such as given therapies. Hence the study of CTCs is not only instrumental as a basic research tool, but also allows the serial monitoring of tumor genotypes and may therefore provide predictive and prognostic biomarkers for clinicians. Here, we review how CTCs have contributed to significant insights into the metastatic process and how they may be utilized in clinical practice.
399 citations
TL;DR: It is shown that nutrient starvation causes rapid depletion of AcCoA, and multiple distinct manipulations designed to increase or reduce cytosolic Ac CoA led to the suppression or induction of autophagy, respectively, both in cultured human cells and in mice, delineating Ac coenzyme A-centered pharmacological strategies that allow for the therapeutic manipulation ofautophagy.
397 citations
Authors
Showing all 5763 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ian J. Deary | 166 | 1795 | 114161 |
| James F. Wilson | 146 | 677 | 101883 |
| Nancy L. Pedersen | 145 | 890 | 94696 |
| William Wijns | 127 | 752 | 95517 |
| Andrew Simmons | 102 | 460 | 36608 |
| Franz Fazekas | 101 | 629 | 49775 |
| Hans-Peter Hartung | 100 | 810 | 49792 |
| Michael Trauner | 98 | 667 | 35543 |
| Dietmar Fuchs | 97 | 1119 | 39758 |
| Funda Meric-Bernstam | 96 | 753 | 36803 |
| Ulf Landmesser | 94 | 564 | 46096 |
| Aysegul A. Sahin | 93 | 322 | 30038 |
| Frank Madeo | 92 | 269 | 45942 |
| Takayoshi Ohkubo | 91 | 631 | 69634 |
| Jürgen C. Becker | 90 | 637 | 28741 |