Institution
Medical University of Graz
Education•Graz, Steiermark, Austria•
About: Medical University of Graz is a education organization based out in Graz, Steiermark, Austria. It is known for research contribution in the topics: Population & Medicine. The organization has 5684 authors who have published 12349 publications receiving 417282 citations.
Topics: Population, Medicine, Cancer, Transplantation, Vitamin D and neurology
Papers published on a yearly basis
Papers
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TL;DR: Although laxatives are most frequently used to ameliorate opioid-induced bowel dysfunction, their efficacy is unsatisfactory and the use of opioid receptor antagonists with limited absorption such as oral prolonged-release naloxone and opioid receptors antagonists that do not penetrate the blood-brain barrier such as methylnaltrexone and alvimopan is addressed.
321 citations
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TL;DR: It is demonstrated that a single oral administration of silver nanoparticles to infant mice colonized with V. cholerae or ETEC significantly reduces the colonization rates of the pathogens by 75- or 100-fold, respectively.
321 citations
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University of Reading1, UCL Institute of Child Health2, University of Tromsø3, German Cancer Research Center4, Boston University5, University of Oulu6, Imperial College London7, University of Groningen8, University of Helsinki9, Sahlgrenska University Hospital10, University College London11, King's College London12, George Washington University13, Wake Forest University14, University of Copenhagen15, Gentofte Hospital16, University of Exeter17, Trinity College, Dublin18, University of Edinburgh19, Ludwig Maximilian University of Munich20, University of Oxford21, Wellcome Trust Centre for Human Genetics22, Oulu University Hospital23, National Institutes of Health24, Finnish Institute of Occupational Health25, Heidelberg University26, University of Southampton27, University of Turku28, Turku University Hospital29, VU University Amsterdam30, Aarhus University Hospital31, University of Bristol32, Uppsala University33, Science for Life Laboratory34, University of Split35, Lund University36, Frederiksberg Hospital37, Harvard University38, University of Tampere39, Medical University of Graz40, Synlab Group41, Vanderbilt University42, GlaxoSmithKline43, University of South Australia44
TL;DR: In this article, the authors used a mendelian randomisation approach to test whether low plasma 25-hydroxyvitamin D (25[OH]D) concentration is causally associated with blood pressure and hypertension risk.
320 citations
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TL;DR: The results suggest that it may be possible to develop an alternative to surgical prostate resection and that such a treatment may also reduce future cancer risk.
Abstract: Organ specific drug targeting was explored in mice as a possible alternative to surgery to treat prostate diseases. Peptides that specifically recognize the vasculature in the prostate were identified from phage-displayed peptide libraries by selecting for phage capable of homing into the prostate after an i.v. injection. One of the phage selected in this manner homed to the prostate 10–15 times more than to other organs. Unselected phage did not show this preference. The phage bound also to vasculature in the human prostate. The peptide displayed by the prostate-homing phage, SMSIARL (single letter code), was synthesized and shown to inhibit the homing of the phage when co-injected into mice with the phage. Systemic treatment of mice with a chimeric peptide consisting of the SMSIARL homing peptide, linked to a proapoptotic peptide that disrupts mitochondrial membranes, caused tissue destruction in the prostate, but not in other organs. The chimeric peptide delayed the development of the cancers in prostate cancer-prone transgenic mice (TRAMP mice). These results suggest that it may be possible to develop an alternative to surgical prostate resection and that such a treatment may also reduce future cancer risk.
320 citations
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TL;DR: This review provides an overview and updated data on the current understanding of the complications associated with oxidative changes in GDM and whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus.
Abstract: Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo development, implantation, placental development and function, fetal development, and labor. However, pathologic pregnancies, including gestational diabetes mellitus (GDM), are associated with a heightened level of oxidative stress, owing to both overproduction of free radicals and/or a defect in the antioxidant defenses. This has important implications on the mother, placental function, and fetal well-being. Animal models of diabetes have confirmed the important role of oxidative stress in the etiology of congenital malformations; the relative immaturity of the antioxidant system facilitates the exposure of embryos and fetuses to the damaging effects of oxidative stress. Of note, there are only a few clinical studies evaluating the potential beneficial effects of antioxidants in GDM. Thus, whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus needs to be explored. This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM.
317 citations
Authors
Showing all 5763 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ian J. Deary | 166 | 1795 | 114161 |
James F. Wilson | 146 | 677 | 101883 |
Nancy L. Pedersen | 145 | 890 | 94696 |
William Wijns | 127 | 752 | 95517 |
Andrew Simmons | 102 | 460 | 36608 |
Franz Fazekas | 101 | 629 | 49775 |
Hans-Peter Hartung | 100 | 810 | 49792 |
Michael Trauner | 98 | 667 | 35543 |
Dietmar Fuchs | 97 | 1119 | 39758 |
Funda Meric-Bernstam | 96 | 753 | 36803 |
Ulf Landmesser | 94 | 564 | 46096 |
Aysegul A. Sahin | 93 | 322 | 30038 |
Frank Madeo | 92 | 269 | 45942 |
Takayoshi Ohkubo | 91 | 631 | 69634 |
Jürgen C. Becker | 90 | 637 | 28741 |