Institution
Memorial Sloan Kettering Cancer Center
Healthcare•New York, New York, United States•
About: Memorial Sloan Kettering Cancer Center is a healthcare organization based out in New York, New York, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 30293 authors who have published 65381 publications receiving 4462534 citations. The organization is also known as: MSKCC & New York Cancer Hospital.
Topics: Cancer, Population, Breast cancer, Radiation therapy, Prostate cancer
Papers published on a yearly basis
Papers
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TL;DR: Depression and hopelessness are the strongest predictors of desire for hastened death in this population of terminally ill cancer patients and provide independent and unique contributions.
Abstract: ContextUnderstanding why some terminally ill patients desire a hastened death
has become an important issue in palliative care and the debate regarding
legalization of assisted suicide.ObjectivesTo assess the prevalence of desire for hastened death among terminally
ill cancer patients and to identify factors corresponding to desire for hastened
death.DesignProspective survey conducted in a 200-bed palliative care hospital in
New York, NY.PatientsNinety-two terminally ill cancer patients (60% female; 70% white; mean
age, 65.9 years) admitted between June 1998 and January 1999 for end-of-life
care who passed a cognitive screening test and provided sufficient data to
permit analysis.Main Outcome MeasureScores on the Schedule of Attitudes Toward Hastened Death (SAHD), a
self-report measure assessing desire for hastened death among individuals
with life-threatening medical illness.ResultsSixteen patients (17%) were classified as having a high desire for hastened
death based on the SAHD and 15 (16%) of 89 patients met criteria for a current
major depressive episode. Desire for hastened death was significantly associated
with a clinical diagnosis of depression (P = .001)
as well as with measures of depressive symptom severity (P<.001) and hopelessness (P<.001). In
multivariate analyses, depression (P = .003) and
hopelessness (P<.001) provided independent and
unique contributions to the prediction of desire for hastened death, while
social support (P = .05) and physical functioning
(P = .02) added significant but smaller contributions.ConclusionsDesire for hastened death among terminally ill cancer patients is not
uncommon. Depression and hopelessness are the strongest predictors of desire
for hastened death in this population and provide independent and unique contributions.
Interventions addressing depression, hopelessness, and social support appear
to be important aspects of adequate palliative care, particularly as it relates
to desire for hastened death.
962 citations
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TL;DR: A CGA, with or without screening, and with follow-up, should be used in older cancer patients, in order to detect unaddressed problems, improve their functional status, and possibly their survival.
Abstract: Background: As more and more cancers occur in elderly people, oncologists are increasingly confronted with the necessity of integrating geriatric parameters in the treatment of their patients. Methods: The International Society of Geriatric Oncology (SIOG) created a task force to review the evidence on the use of a comprehensive geriatric assessment (CGA) in cancer patients. A systematic review of the evidence was conducted. Results: Several biological and clinical correlates of aging have been identified. Their relative weight and clinical usefulness is still poorly defined. There is strong evidence that a CGA detects many problems missed by a regular assessment in general geriatric and in cancer patients. There is also strong evidence that a CGA improves function and reduces hospitalization in the elderly. There is heterogeneous evidence that it improves survival and that it is cost-effective. There is corroborative evidence from a few studies conducted in cancer patients. Screening tools exist and were successfully used in settings such as the emergency room, but globally were poorly tested. The article contains recommendations for the use of CGA in research and clinical care for older cancer patients. Conclusions: A CGA, with or without screening, and with follow-up, should be used in older cancer patients, in order to detect unaddressed problems, improve their functional status, and possibly their survival. The task force cannot recommend any specific tool or approach above others at this point and general geriatric experience should be used.
962 citations
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Memorial Sloan Kettering Cancer Center1, University of Ulsan2, Institut Gustave Roussy3, Japanese Foundation for Cancer Research4, Showa University5, Kindai University6, Yonsei University7, National Cancer Research Institute8, University of California, Los Angeles9, Daiichi Sankyo10, Harvard University11
TL;DR: Tastuzumab deruxtecan showed durable antitumor activity in a pretreated patient population with HER2-positive metastatic breast cancer and requires attention to pulmonary symptoms and careful monitoring.
Abstract: Background Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable tetrapeptide-based linke...
961 citations
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TL;DR: It is proposed that impaired homology-directed repair caused by BRCA2 deficiency leads to chromosomal instability and, possibly, tumorigenesis, through lack of repair or misrepair of DNA damage.
961 citations
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TL;DR: It is suggested that signal-induced ncRNAs localized to regulatory regions of transcription units can act cooperatively as selective ligands, recruiting and modulating the activities of distinct classes of RNA-binding co-regulators in response to specific signals, providing an unexpected ncRNA/RNA-binding protein-based strategy to integrate transcriptional programmes.
Abstract: With the recent recognition of non-coding RNAs (ncRNAs) flanking many genes, a central issue is to obtain a full understanding of their potential roles in regulated gene transcription programmes, possibly through different mechanisms. Here we show that an RNA-binding protein, TLS (for translocated in liposarcoma), serves as a key transcriptional regulatory sensor of DNA damage signals that, on the basis of its allosteric modulation by RNA, specifically binds to and inhibits CREB-binding protein (CBP) and p300 histone acetyltransferase activities on a repressed gene target, cyclin D1 (CCND1) in human cell lines. Recruitment of TLS to the CCND1 promoter to cause gene-specific repression is directed by single-stranded, low-copy-number ncRNA transcripts tethered to the 5' regulatory regions of CCND1 that are induced in response to DNA damage signals. Our data suggest that signal-induced ncRNAs localized to regulatory regions of transcription units can act cooperatively as selective ligands, recruiting and modulating the activities of distinct classes of RNA-binding co-regulators in response to specific signals, providing an unexpected ncRNA/RNA-binding protein-based strategy to integrate transcriptional programmes.
954 citations
Authors
Showing all 30708 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gordon H. Guyatt | 231 | 1620 | 228631 |
Edward Giovannucci | 206 | 1671 | 179875 |
Irving L. Weissman | 201 | 1141 | 172504 |
Craig B. Thompson | 195 | 557 | 173172 |
Joan Massagué | 189 | 408 | 149951 |
Gad Getz | 189 | 520 | 247560 |
Chris Sander | 178 | 713 | 233287 |
Richard B. Lipton | 176 | 2110 | 140776 |
Richard K. Wilson | 173 | 463 | 260000 |
George P. Chrousos | 169 | 1612 | 120752 |
Stephen J. Elledge | 162 | 406 | 112878 |
Murray F. Brennan | 161 | 925 | 97087 |
Lewis L. Lanier | 159 | 554 | 86677 |
David W. Bates | 159 | 1239 | 116698 |
Dan R. Littman | 157 | 426 | 107164 |