National Institutes of Health

About: National Institutes of Health is a government organization based out in Bethesda, Maryland, United States. It is known for research contribution in the topics: Population & Gene. The organization has 149298 authors who have published 297896 publications receiving 21337431 citations. The organization is also known as: NIH & U.S. National Institutes of Health.

American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer

Abstract: An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical precancerous lesions and cancer is presented. The guidelines are based on a systematic evidence review, contributions from 6 working groups, and a recent symposium cosponsored by the ACS, the American Society for Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology, which was attended by 25 organizations. The new screening recommendations address age-appropriate screening strategies, including the use of cytology and high-risk human papillomavirus (HPV) testing, follow-up (eg, the management of screen positives and screening intervals for screen negatives) of women after screening, the age at which to exit screening, future considerations regarding HPV testing alone as a primary screening approach, and screening strategies for women vaccinated against HPV16 and HPV18 infections.

Personality in adulthood: a six-year longitudinal study of self-reports and spouse ratings on the NEO Personality Inventory.

Abstract: Previous longitudinal studies of personality in adulthood have been limited in the range of traits examined, have chiefly made use of self-reports, and have frequently included only men. In this study, self-reports (N = 983) and spouse ratings (N = 167) were gathered on the NEO Personality Inventory (Costa & McCrae, 1985b), which measures all five of the major dimensions of normal personality. Cross-sectional and longitudinal analyses on data from men and women aged 21 to 96 years showed evidence of small declines in Activity, Positive Emotions, and openness to Actions that might be attributed to maturation, but none of these effects was replicated in sequential analyses. The 20 other scales examined showed no consistent pattern of maturational effects. In contrast, retest stability was quite high for all five dimensions in self-reports and for the three dimensions measured at both times in spouse ratings. Comparable levels of stability were seen for men and women and for younger and older subjects. The data support the position that personality is stable after age 30.

Radical causes of cancer

Abstract: Free radicals are ubiquitous in our body and are generated by normal physiological processes, including aerobic metabolism and inflammatory responses, to eliminate invading pathogenic microorganisms. Because free radicals can also inflict cellular damage, several defences have evolved both to protect our cells from radicals--such as antioxidant scavengers and enzymes--and to repair DNA damage. Understanding the association between chronic inflammation and cancer provides insights into the molecular mechanisms involved. In particular, we highlight the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis.