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Seung-Ki Kim
Researcher at New Generation University College
Publications - 440
Citations - 12874
Seung-Ki Kim is an academic researcher from New Generation University College. The author has contributed to research in topics: Medicine & Moyamoya disease. The author has an hindex of 50, co-authored 389 publications receiving 10501 citations. Previous affiliations of Seung-Ki Kim include Brigham and Women's Hospital & Seoul National University Hospital.
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Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Florence M.G. Cavalli,Marc Remke,Marc Remke,Marc Remke,Ladislav Rampášek,John Peacock,David Shih,Betty Luu,Livia Garzia,Jonathon Torchia,Carolina Nor,A. Sorana Morrissy,Sameer Agnihotri,Yuan Yao Thompson,Claudia M. Kuzan-Fischer,Hamza Farooq,Keren Isaev,Keren Isaev,Craig Daniels,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Ji Yeoun Lee,Wiesława Grajkowska,Marta Perek-Polnik,Alexandre Vasiljevic,Cécile Faure-Conter,Anne Jouvet,Caterina Giannini,Amulya A. Nageswara Rao,Kay Ka Wai Li,Ho Keung Ng,Charles G. Eberhart,Ian F. Pollack,Ronald L. Hamilton,G. Yancey Gillespie,James M. Olson,James M. Olson,Sarah Leary,William A. Weiss,Boleslaw Lach,Boleslaw Lach,Lola B. Chambless,Reid C. Thompson,Michael K. Cooper,Rajeev Vibhakar,Peter Hauser,Marie Lise C. van Veelen,Johan M. Kros,Pim J. French,Young Shin Ra,Toshihiro Kumabe,Enrique López-Aguilar,Karel Zitterbart,Jaroslav Sterba,Gaetano Finocchiaro,Maura Massimino,Erwin G. Van Meir,Satoru Osuka,Tomoko Shofuda,Almos Klekner,Massimo Zollo,Jeffrey R. Leonard,Joshua B. Rubin,Nada Jabado,Steffen Albrecht,Steffen Albrecht,Jaume Mora,Timothy E. Van Meter,Shin Jung,Andrew S. Moore,Andrew R. Hallahan,Jennifer A. Chan,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Maryam Fouladi,José Pimentel,Claudia C. Faria,Ali G. Saad,Luca Massimi,Linda M. Liau,Helen Wheeler,Hideo Nakamura,Samer K. Elbabaa,Mario Perezpeña-Diazconti,Fernando Chico Ponce de León,Shenandoah Robinson,Michal Zapotocky,Alvaro Lassaletta,Annie Huang,Cynthia Hawkins,Uri Tabori,Eric Bouffet,Ute Bartels,Peter B. Dirks,James T. Rutka,Gary D. Bader,Jüri Reimand,Jüri Reimand,Anna Goldenberg,Vijay Ramaswamy,Michael D. Taylor +101 more
TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.
Journal ArticleDOI
Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma
Nataliya Zhukova,Vijay Ramaswamy,Marc Remke,Elke Pfaff,David Shih,Dianna Martin,Pedro Castelo-Branco,Berivan Baskin,Peter N. Ray,Eric Bouffet,André O. von Bueren,André O. von Bueren,David T.W. Jones,Paul A. Northcott,M Kool,Dominik Sturm,Trevor J. Pugh,Scott L. Pomeroy,Yoon Jae Cho,Torsten Pietsch,Marco Gessi,Stefan Rutkowski,László Bognár,Almos Klekner,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Charles G. Eberhart,Michelle Fèvre-Montange,Maryam Fouladi,Pim J. French,Max Kros,Wiesława Grajkowska,Nalin Gupta,William A. Weiss,Peter Hauser,Nada Jabado,Anne Jouvet,Shin Jung,Toshihiro Kumabe,Boleslaw Lach,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Luca Massimi,Ian F. Pollack,Young Shin Ra,Erwin G. Van Meir,Karel Zitterbart,Ulrich Schüller,Rebecca M Hill,Janet C. Lindsey,Edward C. Schwalbe,Simon Bailey,David W. Ellison,Cynthia Hawkins,David Malkin,Steven C. Clifford,Andrey Korshunov,Stefan M. Pfister,Michael D. Taylor,Uri Tabori +61 more
TL;DR: Subgroup-specific analysis reconciles prior conflicting publications and confirms that TP53 mutations are enriched among SHH medulloblastomas, in which they portend poor outcome and account for a large proportion of treatment failures in these patients.
Journal ArticleDOI
Divergent clonal selection dominates medulloblastoma at recurrence
A. Sorana Morrissy,Livia Garzia,David Shih,Scott Zuyderduyn,Xi Huang,Patryk Skowron,Marc Remke,Florence M.G. Cavalli,Vijay Ramaswamy,Patricia Lindsay,Salomeh Jelveh,Laura K. Donovan,Xin Wang,Betty Luu,Kory Zayne,Yisu Li,Chelsea Mayoh,Nina Thiessen,Eloi Mercier,Karen Mungall,Yusanne Ma,Kane Tse,Thomas Zeng,Karey Shumansky,Andrew Roth,Sohrab P. Shah,Hamza Farooq,Noriyuki Kijima,Borja L. Holgado,John J.Y. Lee,Stuart Matan-Lithwick,Jessica Liu,Stephen C. Mack,Stephen C. Mack,Alex Manno,K. A. Michealraj,Carolina Nor,John Peacock,Lei Qin,Jüri Reimand,Adi Rolider,Yuan Yao Thompson,Xiaochong Wu,Trevor J. Pugh,Adrian Ally,Mikhail Bilenky,Yaron S.N. Butterfield,Rebecca Carlsen,Young Cheng,Eric Chuah,Richard Corbett,Noreen Dhalla,An He,Darlene Lee,Haiyan I. Li,William Long,Michael Mayo,Patrick Plettner,Jenny Q. Qian,Jacqueline E. Schein,Angela Tam,Tina Wong,Inanc Birol,Inanc Birol,Yongjun Zhao,Claudia C. Faria,José Pimentel,Sofia Nunes,Tarek Shalaby,Michael A. Grotzer,Ian F. Pollack,Ronald L. Hamilton,Xiao-Nan Li,Anne Bendel,Daniel W. Fults,Andrew W. Walter,Toshihiro Kumabe,Teiji Tominaga,V. Peter Collins,Yoon Jae Cho,Caitlin Hoffman,David Lyden,Jeffrey H. Wisoff,James Garvin,Duncan Stearns,Luca Massimi,Ulrich Schüller,Jaroslav Sterba,Karel Zitterbart,Stéphanie Puget,Olivier Ayrault,Sandra E. Dunn,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Helen Wheeler,Andrew R. Hallahan,Wendy J. Ingram,Tobey J. MacDonald,Jeffrey J. Olson,Erwin G. Van Meir,Ji Yeoun Lee,Kyu-Chang Wang,Seung-Ki Kim,Byung Kyu Cho,Torsten Pietsch,Gudrun Fleischhack,Stephan Tippelt,Young Shin Ra,Simon Bailey,Janet C. Lindsey,Steven C. Clifford,Charles G. Eberhart,Michael K. Cooper,Roger J. Packer,Maura Massimino,Maria Luisa Garrè,Ute Bartels,Uri Tabori,Cynthia Hawkins,Peter B. Dirks,Eric Bouffet,James T. Rutka,Robert J. Wechsler-Reya,William A. Weiss,Lara S. Collier,Adam J. Dupuy,Andrey Korshunov,David T.W. Jones,Marcel Kool,Paul A. Northcott,Stefan M. Pfister,Stefan M. Pfister,David A. Largaespada,Andrew J. Mungall,Richard A. Moore,Nada Jabado,Gary D. Bader,Steven J.M. Jones,Steven J.M. Jones,David Malkin,Marco A. Marra,Michael D. Taylor +141 more
TL;DR: Targeted therapy is unlikely to be effective in the absence of the target, therefore the results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.
Journal ArticleDOI
Cytogenetic Prognostication Within Medulloblastoma Subgroups
David Shih,Paul A. Northcott,Marc Remke,Andrey Korshunov,Vijay Ramaswamy,Marcel Kool,Betty Luu,Yuan Yao,Xin Wang,Adrian M. Dubuc,Livia Garzia,John Peacock,Stephen C. Mack,Xiaochong Wu,Adi Rolider,A. Sorana Morrissy,Florence M.G. Cavalli,David T.W. Jones,Karel Zitterbart,Claudia C. Faria,Claudia C. Faria,Ulrich Schüller,Leos Kren,Toshihiro Kumabe,Teiji Tominaga,Young Shin Ra,Miklós Garami,Peter Hauser,Jennifer A. Chan,Shenandoah Robinson,László Bognár,Almos Klekner,Ali G. Saad,Linda M. Liau,Steffen Albrecht,Adam M. Fontebasso,Giuseppe Cinalli,Pasqualino De Antonellis,Massimo Zollo,Michael K. Cooper,Reid C. Thompson,Simon Bailey,Janet C. Lindsey,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Stephen W. Scherer,Joanna J. Phillips,Nalin Gupta,Xing Fan,Karin M. Muraszko,Rajeev Vibhakar,Charles G. Eberhart,Maryam Fouladi,Boleslaw Lach,Shin Jung,Robert J. Wechsler-Reya,Michelle Fèvre-Montange,Anne Jouvet,Nada Jabado,Ian F. Pollack,William A. Weiss,Ji Yeoun Lee,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Jeffrey R. Leonard,Joshua B. Rubin,Carmen de Torres,Cinzia Lavarino,Jaume Mora,Yoon Jae Cho,Uri Tabori,James M. Olson,Amar Gajjar,Roger J. Packer,Stefan Rutkowski,Scott L. Pomeroy,Pim J. French,Nanne K. Kloosterhof,Johan M. Kros,Erwin G. Van Meir,Steven C. Clifford,Franck Bourdeaut,Olivier Delattre,François Doz,François Doz,Cynthia Hawkins,David Malkin,Wiesława Grajkowska,Marta Perek-Polnik,Eric Bouffet,James T. Rutka,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor +95 more
TL;DR: A small panel of cytogenetic biomarkers is identified that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials.