Institution
Pennsylvania State University
Education•State College, Pennsylvania, United States•
About: Pennsylvania State University is a education organization based out in State College, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 79763 authors who have published 196876 publications receiving 8318601 citations. The organization is also known as: Penn State & PSU.
Topics: Population, Poison control, Dielectric, Context (language use), Galaxy
Papers published on a yearly basis
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TL;DR: In this paper, the authors provide an overview of the analysis and interpretation of channel profiles in erosional mountain ranges and show that existing data support theoretical expectations of positive, monotonic relationships between channel steepness index, a measure of channel gradient normalized for downstream increases in drainage area, and erosion rate at equilibrium, and that the transient response to perturbations away from equilibrium engenders specific spatial patterns in channel profiles that can be used to infer the forcing.
742 citations
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TL;DR: In this paper, an update to Golder's (2005) Democratic Electoral Systems (DES) dataset was presented, which includes all legislative and presidential elections that took place in democratic states from 2001 to 2011.
741 citations
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TL;DR: Development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases.
Abstract: Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-κB is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κB has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases.
741 citations
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TL;DR: Evidence is presented that human TAF(II)250 and its homologs in Drosophila and yeast have histone acetyltransferase (HAT) activity in vitro, which suggests that targeted hist one acetylation at specific promoters by TAF (II) 250 may be involved in mechanisms by which TFIID gains access to transcriptionally repressed chromatin.
741 citations
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University of Potsdam1, Université Paris-Saclay2, Purdue University3, Japan Agency for Marine-Earth Science and Technology4, University of California, Berkeley5, University of Southern California6, Pennsylvania State University7, Northwestern University8, Columbia University9, University of Nantes10, University of Washington11, Technische Universität München12, California Institute of Technology13, University of Colorado Boulder14, Texas A&M University15, ETH Zurich16
TL;DR: In this paper, the authors review the factors and processes that are known to influence the hydrogen-isotopic compositions of lipids from photosynthesizing organisms, and provide a framework for interpreting their D/H ratios from ancient sediments and identify future research opportunities.
Abstract: Hydrogen-isotopic abundances of lipid biomarkers are emerging as important proxies in the study of ancient environments and ecosystems. A decade ago, pioneering studies made use of new analytical methods and demonstrated that the hydrogen-isotopic composition of individual lipids from aquatic and terrestrial organisms can be related to the composition of their growth (i.e., environmental) water. Subsequently, compound-specific deuterium/hydrogen (D/H) ratios of sedimentary biomarkers have been increasingly used as paleohydrological proxies over a range of geological timescales. Isotopic fractionation observed between hydrogen in environmental water and hydrogen in lipids, however, is sensitive to biochemical, physiological, and environmental influences on the composition of hydrogen available for biosynthesis in cells. Here we review the factors and processes that are known to influence the hydrogen-isotopic compositions of lipids-especially n-alkanes-from photosynthesizing organisms, and we provide a framework for interpreting their D/H ratios from ancient sediments and identify future research opportunities.
740 citations
Authors
Showing all 80524 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Donald P. Schneider | 242 | 1622 | 263641 |
David J. Hunter | 213 | 1836 | 207050 |
Robert M. Califf | 196 | 1561 | 167961 |
Martin White | 196 | 2038 | 232387 |
Eric J. Topol | 193 | 1373 | 151025 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Jing Wang | 184 | 4046 | 202769 |
Dennis S. Charney | 179 | 802 | 122408 |
David Haussler | 172 | 488 | 224960 |
Chad A. Mirkin | 164 | 1078 | 134254 |
Ian A. Wilson | 158 | 971 | 98221 |
David Cella | 156 | 1258 | 106402 |
Jay Hauser | 155 | 2145 | 132683 |