Institution
Pennsylvania State University
Education•State College, Pennsylvania, United States•
About: Pennsylvania State University is a education organization based out in State College, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 79763 authors who have published 196876 publications receiving 8318601 citations. The organization is also known as: Penn State & PSU.
Topics: Population, Poison control, Dielectric, Context (language use), Galaxy
Papers published on a yearly basis
Papers
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TL;DR: Graphene/Mn3O4 composites were prepared by a simple hydrothermal process from KMnO4 using ethylene glycol as a reducing agent in this paper.
Abstract: Graphene/Mn3O4 composites were prepared by a simple hydrothermal process from KMnO4 using ethylene glycol as a reducing agent. Mn3O4 nanorods of 100 nm to 1 μm length were observed to be well-dispersed on graphene sheets. To assess the properties of these materials for use in supercapacitors, cyclic voltammetry and galvanostatic charging–discharging measurements were performed. Graphene/Mn3O4 composites could be charged and discharged faster and had higher capacitance than free Mn3O4 nanorods. The capacitance of the composites was 100% retained after 10 000 cycles at a charging rate of 5 A/g.
720 citations
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TL;DR: The development of the concept attributed adjacency graph (AAG) for the recognition of machined features from a 3D boundary representation of a solid is presented.
Abstract: The internal representation of the solid modeller provides a description of parts which when used directly is useful for automation of the process planning function. So that the CAD model can be used to provide the information required for manufacturing, techniques to improve machine understanding of the part as required for manufacturing are needed. This paper presents the development of the concept attributed adjacency graph (AAG) for the recognition of machined features from a 3D boundary representation of a solid. Current implementation of the feature recogniser is limited to polyhedral features such as pockets, slots, steps, blind steps, blind slots, and polyhedral holes. Sample results that show the capabilities of the system are presented.
720 citations
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University of Luxembourg1, University of Chile2, University of California, San Diego3, European Bioinformatics Institute4, Pennsylvania State University5, Georgia Institute of Technology6, University of Navarra7, University of Latvia8, PSL Research University9, Stanford University10, University of Michigan11, Utah State University12, Imperial College London13, University of Alicante14, California Institute of Technology15, Technical University of Denmark16, Leiden University17
TL;DR: This protocol provides an overview of all new features of the COBRA Toolbox and can be adapted to generate and analyze constraint-based models in a wide variety of scenarios.
Abstract: Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental molecular systems biology data and quantitative prediction of physicochemically and biochemically feasible phenotypic states. The COBRA Toolbox is a comprehensive desktop software suite of interoperable COBRA methods. It has found widespread application in biology, biomedicine, and biotechnology because its functions can be flexibly combined to implement tailored COBRA protocols for any biochemical network. This protocol is an update to the COBRA Toolbox v.1.0 and v.2.0. Version 3.0 includes new methods for quality-controlled reconstruction, modeling, topological analysis, strain and experimental design, and network visualization, as well as network integration of chemoinformatic, metabolomic, transcriptomic, proteomic, and thermochemical data. New multi-lingual code integration also enables an expansion in COBRA application scope via high-precision, high-performance, and nonlinear numerical optimization solvers for multi-scale, multi-cellular, and reaction kinetic modeling, respectively. This protocol provides an overview of all these new features and can be adapted to generate and analyze constraint-based models in a wide variety of scenarios. The COBRA Toolbox v.3.0 provides an unparalleled depth of COBRA methods.
719 citations
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TL;DR: Alice K. Jacobs,MD, FACC, FAHA, Chair Jeffrey L. Anderson, MD, F ACC, FAH, Chair-Elect Nancy Albert, PhD, CCNS, CCRN,FAHA, chair-Elect.
Abstract: Alice K. Jacobs, MD, FACC, FAHA, Chair
Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect
Nancy Albert, PhD, CCNS, CCRN, FAHA
Mark A. Creager, MD, FACC, FAHA
Steven M. Ettinger, MD, FACC
Robert A. Guyton, MD, FACC
Jonathan L. Halperin, MD, FACC, FAHA
Judith S. Hochman, MD, FACC, FAHA
719 citations
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TL;DR: The circulating cytokine response to pneumonia is heterogeneous and continues for more than a week after presentation, with considerable overlap between those who do and do not develop severe sepsis.
Abstract: Background: Severe sepsis is common and frequently fatal, and community-acquired pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to uncontrolled and unbalanced inflammation, evidence from humans with infection syndromes across the breadth of disease is lacking. In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death. Methods: This is a cohort study of 1886 subjects hospitalized with CAP through the emergency departments in 28 US academic and community hospitals. We defined severe sepsis as CAP complicated by new-onset organ dysfunction, following international consensus conference criteria. We measured plasma tumor necrosis factor, IL-6 (interleukin 6), and IL-10 levels daily for the first week and weekly thereafter. Our main outcome measures were severe sepsis and 90-day mortality. Results: A total of 583 patients developed severe sepsis (31%), of whom 149 died (26%). Systemic cytokine level elevation occurred in 82% of all subjects with CAP. Mean cytokine concentrations were highest at presentation, declined rapidly over the first few days, but remained elevated throughout the first week, beyond resolution of clinical signs of infection. Cytokine levels were highest in fatal severe sepsis and lowest in CAP with no severe sepsis. Unbalanced (high/low) cytokine patterns were unusual (4.6%) and not associated with decreased survival. Highest risk of death was with combined high levels of the proinflammatory IL-6 and anti-inflammatory IL-10 cytokine activity (hazard ratio, 20.5; 95% confidence interval, 10.8-39.0) (P.001). Conclusions: The circulating cytokine response to pneumonia is heterogeneous and continues for more than a week after presentation, with considerable overlap between those who do and do not develop severe sepsis. Unbalanced activation is uncommon, and mortality is highest w hen b oth p roinflammatory a nd a ntiinflammatory cytokine levels are high.
718 citations
Authors
Showing all 80524 results
Name | H-index | Papers | Citations |
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Robert Langer | 281 | 2324 | 326306 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Donald P. Schneider | 242 | 1622 | 263641 |
David J. Hunter | 213 | 1836 | 207050 |
Robert M. Califf | 196 | 1561 | 167961 |
Martin White | 196 | 2038 | 232387 |
Eric J. Topol | 193 | 1373 | 151025 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Jing Wang | 184 | 4046 | 202769 |
Dennis S. Charney | 179 | 802 | 122408 |
David Haussler | 172 | 488 | 224960 |
Chad A. Mirkin | 164 | 1078 | 134254 |
Ian A. Wilson | 158 | 971 | 98221 |
David Cella | 156 | 1258 | 106402 |
Jay Hauser | 155 | 2145 | 132683 |