Pennsylvania State University

About: Pennsylvania State University is a education organization based out in State College, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 79763 authors who have published 196876 publications receiving 8318601 citations. The organization is also known as: Penn State & PSU.

Is It Really Just a Social Construction?: The Contribution of the Physical Environment to Sense of Place

Abstract: Although sense of place definitions nominally include the physical environment, much research has emphasized the social construction of sense of place and neglect the potentially important contributions of the physical environment to place meanings and attachment. This article presents research that tests several models that integrate (1) characteristics of the environment, (2) human uses of the environment, (3) constructed meanings, and (4) place attachment and satisfaction. The research utilized a mail survey of 1,000 property owners in a lake-rich region (the Northern Highlands Lake District of Northern Wisconsin). Structural equation modeling revealed that the best fit model integrating environmental variables with sense of place was a meaning-mediated model that considered certain landscape attributes (i.e., level of shoreline development) as predictive of certain meanings related to attachment and satisfaction. This research demonstrates that landscape attributes matter a great deal to constructed m...

Automatic Linguistic Indexing of Pictures by a statistical modeling approach

Abstract: Automatic linguistic indexing of pictures is an important but highly challenging problem for researchers in computer vision and content-based image retrieval. In this paper, we introduce a statistical modeling approach to this problem. Categorized images are used to train a dictionary of hundreds of statistical models each representing a concept. Images of any given concept are regarded as instances of a stochastic process that characterizes the concept. To measure the extent of association between an image and the textual description of a concept, the likelihood of the occurrence of the image based on the characterizing stochastic process is computed. A high likelihood indicates a strong association. In our experimental implementation, we focus on a particular group of stochastic processes, that is, the two-dimensional multiresolution hidden Markov models (2D MHMMs). We implemented and tested our ALIP (Automatic Linguistic Indexing of Pictures) system on a photographic image database of 600 different concepts, each with about 40 training images. The system is evaluated quantitatively using more than 4,600 images outside the training database and compared with a random annotation scheme. Experiments have demonstrated the good accuracy of the system and its high potential in linguistic indexing of photographic images.

Loop Quantum Cosmology: A Status Report

Abstract: Loop quantum cosmology (LQC) is the result of applying principles of loop quantum gravity (LQG) to cosmological settings. The distinguishing feature of LQC is the prominent role played by the quantum geometry effects of LQG. In particular, quantum geometry creates a brand new repulsive force which is totally negligible at low spacetime curvature but rises very rapidly in the Planck regime, overwhelming the classical gravitational attraction. In cosmological models, while Einstein's equations hold to an excellent degree of approximation at low curvature, they undergo major modifications in the Planck regime: for matter satisfying the usual energy conditions, any time a curvature invariant grows to the Planck scale, quantum geometry effects dilute it, thereby resolving singularities of general relativity. Quantum geometry corrections become more sophisticated as the models become richer. In particular, in anisotropic models, there are significant changes in the dynamics of shear potentials which tame their singular behavior in striking contrast to older results on anisotropies in bouncing models. Once singularities are resolved, the conceptual paradigm of cosmology changes and one has to revisit many of the standard issues—e.g. the 'horizon problem'—from a new perspective. Such conceptual issues as well as potential observational consequences of the new Planck scale physics are being explored, especially within the inflationary paradigm. These considerations have given rise to a burst of activity in LQC in recent years, with contributions from quantum gravity experts, mathematical physicists and cosmologists. The goal of this review is to provide an overview of the current state of the art in LQC for three sets of audiences: young researchers interested in entering this area; the quantum gravity community in general and cosmologists who wish to apply LQC to probe modifications in the standard paradigm of the early universe. In this review, effort has been made to streamline the material so that each of these communities can read only the sections they are most interested in, without loss of continuity.

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

Abstract: Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that have been implicated in innate immune response to bacterial infection. Neutrophils express high levels of peptidylarginine deiminase 4 (PAD4), which catalyzes histone citrullination. However, whether PAD4 or histone citrullination plays a role in chromatin structure in neutrophils is unclear. In this study, we show that the hypercitrullination of histones by PAD4 mediates chromatin decondensation. Histone hypercitrullination is detected on highly decondensed chromatin in HL-60 granulocytes and blood neutrophils. The inhibition of PAD4 decreases histone hypercitrullination and the formation of NET-like structures, whereas PAD4 treatment of HL-60 cells facilitates these processes. The loss of heterochromatin and multilobular nuclear structures is detected in HL-60 granulocytes after PAD4 activation. Importantly, citrullination of biochemically defined avian nucleosome arrays inhibits their compaction by the linker histone H5 to form higher order chromatin structures. Together, these results suggest that histone hypercitrullination has important functions in chromatin decondensation in granulocytes/neutrophils.