Institution
Pennsylvania State University
Education•State College, Pennsylvania, United States•
About: Pennsylvania State University is a education organization based out in State College, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 79763 authors who have published 196876 publications receiving 8318601 citations. The organization is also known as: Penn State & PSU.
Topics: Population, Poison control, Dielectric, Context (language use), Galaxy
Papers published on a yearly basis
Papers
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TL;DR: To meet the challenge of promoting healthy weight in children in the current eating environment, parents need guidance regarding alternatives to traditional feeding practices.
Abstract: The first years of life mark a time of rapid development and dietary change, as children transition from an exclusive milk diet to a modified adult diet. During these early years, children's learning about food and eating plays a central role in shaping subsequent food choices, diet quality, and weight status. Parents play a powerful role in children's eating behavior, providing both genes and environment for children. For example, they influence children's developing preferences and eating behaviors by making some foods available rather than others, and by acting as models of eating behavior. In addition, parents use feeding practices, which have evolved over thousands of years, to promote patterns of food intake necessary for children's growth and health. However in current eating environments, characterized by too much inexpensive palatable, energy dense food, these traditional feeding practices can promote overeating and weight gain. To meet the challenge of promoting healthy weight in children in the current eating environment, parents need guidance regarding alternatives to traditional feeding practices.
1,235 citations
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TL;DR: The other source of power dissipation in microprocessors, dynamic power, arises from the repeated capacitance charge and discharge on the output of the hundreds of millions of gates in today's chips.
Abstract: Off-state leakage is static power, current that leaks through transistors even when they are turned off. The other source of power dissipation in today's microprocessors, dynamic power, arises from the repeated capacitance charge and discharge on the output of the hundreds of millions of gates in today's chips. Until recently, only dynamic power has been a significant source of power consumption, and Moore's law helped control it. However, power consumption has now become a primary microprocessor design constraint; one that researchers in both industry and academia will struggle to overcome in the next few years. Microprocessor design has traditionally focused on dynamic power consumption as a limiting factor in system integration. As feature sizes shrink below 0.1 micron, static power is posing new low-power design challenges.
1,233 citations
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TL;DR: It is discovered that the hepatitis C virus (HCV) envelope glycoprotein E2 binds to human hepatoma cell lines independently of the previously proposed HCV receptor CD81, and the receptor responsible for E2 binding to human hepatic cells is identified as the human scavenger receptor class B type I (SR‐BI).
Abstract: We discovered that the hepatitis C virus (HCV) envelope glycoprotein E2 binds to human hepatoma cell lines independently of the previously proposed HCV receptor CD81. Comparative binding studies using recombinant E2 from the most prevalent 1a and 1b genotypes revealed that E2 recognition by hepatoma cells is independent from the viral isolate, while E2–CD81 interaction is isolate specific. Binding of soluble E2 to human hepatoma cells was impaired by deletion of the hypervariable region 1 (HVR1), but the wild-type phenotype was recovered by introducing a compensatory mutation reported previously to rescue infectivity of an HVR1-deleted HCV infectious clone. We have identified the receptor responsible for E2 binding to human hepatic cells as the human scavenger receptor class B type I (SR-BI). E2–SR-BI interaction is very selective since neither mouse SR-BI nor the closely related human scavenger receptor CD36, were able to bind E2. Finally, E2 recognition by SR-BI was competed out in an isolate-specific manner both on the hepatoma cell line and on the human SR-BI-transfected cell line by an anti-HVR1 monoclonal antibody.
1,223 citations
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TL;DR: This protocol describes the dextran sulfate sodium (DSS)‐induced colitis model, focusing on details and factors that could affect DSS‐induced pathology.
Abstract: Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis and Crohn's Disease, are complex and multifactorial diseases with unknown etiology. For the past 20 years, to study human IBD mechanistically, a number of murine models of colitis have been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate a number of potential therapeutics. Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed. This protocol describes the DSS-induced colitis model, focusing on details and factors that could affect DSS-induced pathology.
1,221 citations
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National Institute of Advanced Industrial Science and Technology1, University of Bari2, Air Products & Chemicals3, University of Delaware4, University of Pittsburgh5, University of California, Berkeley6, California Institute of Technology7, Brookhaven National Laboratory8, Karlsruhe Institute of Technology9, Environmental Molecular Sciences Laboratory10, Tokyo Institute of Technology11, National Renewable Energy Laboratory12, Los Alamos National Laboratory13, University of Louisville14, Texas A&M University15, Sandia National Laboratories16, Northwestern University17, DuPont18, Emory University19, University of Oklahoma20, University of Southern California21, University of Minnesota22, Pennsylvania State University23, Idaho National Laboratory24
TL;DR: The goal of the "Opportunities for Catalysis Research in Carbon Management" workshop was to review within the context of greenhouse gas/carbon issues the current state of knowledge, barriers to further scientific and technological progress, and basic scientific research needs in the areas of H2 generation and utilization.
Abstract: There is increased recognition by the world’s scientific, industrial, and political communities that the concentrations of greenhouse gases in the earth’s
atmosphere, particularly CO_2, are increasing. For
example, recent studies of Antarctic ice cores to
depths of over 3600 m, spanning over 420 000 years,
indicate an 80 ppm increase in atmospheric CO_2 in
the past 200 years (with most of this increase
occurring in the past 50 years) compared to the
previous 80 ppm increase that required 10 000 years.2
The 160 nation Framework Convention for Climate
Change (FCCC) in Kyoto focused world attention on
possible links between CO2 and future climate change
and active discussion of these issues continues.3 In
the United States, the PCAST report4 “Federal
Energy Research and Development for the Challenges
of the Twenty First Century” focused attention
on the growing worldwide demand for energy and the
need to move away from current fossil fuel utilization.
According to the U.S. DOE Energy Information
Administration,5 carbon emission from the transportation
(air, ground, sea), industrial (heavy manufacturing,
agriculture, construction, mining, chemicals,
petroleum), buildings (internal heating, cooling, lighting),
and electrical (power generation) sectors of the
World economy amounted to ca. 1823 million metric
tons (MMT) in 1990, with an estimated increase to
2466 MMT in 2008-2012 (Table 1).
1,220 citations
Authors
Showing all 80524 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Donald P. Schneider | 242 | 1622 | 263641 |
David J. Hunter | 213 | 1836 | 207050 |
Robert M. Califf | 196 | 1561 | 167961 |
Martin White | 196 | 2038 | 232387 |
Eric J. Topol | 193 | 1373 | 151025 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Jing Wang | 184 | 4046 | 202769 |
Dennis S. Charney | 179 | 802 | 122408 |
David Haussler | 172 | 488 | 224960 |
Chad A. Mirkin | 164 | 1078 | 134254 |
Ian A. Wilson | 158 | 971 | 98221 |
David Cella | 156 | 1258 | 106402 |
Jay Hauser | 155 | 2145 | 132683 |