Institution
Technical University of Denmark
Education•Kongens Lyngby, Hovedstaden, Denmark•
About: Technical University of Denmark is a education organization based out in Kongens Lyngby, Hovedstaden, Denmark. It is known for research contribution in the topics: Population & Catalysis. The organization has 24126 authors who have published 66394 publications receiving 2443649 citations. The organization is also known as: Danmarks Tekniske Universitet & DTU.
Topics: Population, Catalysis, Wind power, Computer science, Laser
Papers published on a yearly basis
Papers
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TL;DR: The in vitro and in vivo antagonism of antibacterial strainPseudomonas fluorescens strain AH2 against the fish-pathogenic bacterium Vibrio anguillarum was evaluated and the combined probiotic treatment resulted in a 46% reduction of calculated accumulated mortality.
Abstract: To study the possible use of probiotics in fish farming, we evaluated the in vitro and in vivo antagonism of antibacterial strain Pseudomonas fluorescens strain AH2 against the fish-pathogenic bacterium Vibrio anguillarum. As iron is important in virulence and bacterial interactions, the effect of P. fluorescens AH2 was studied under iron-rich and iron-limited conditions. Sterile-filtered culture supernatants from iron-limited P. fluorescens AH2 inhibited the growth of V. anguillarum, whereas sterile-filtered supernatants from iron-replete cultures of P. fluorescens AH2 did not. P. fluorescens AH2 inhibited the growth of V. anguillarum during coculture, independently of the iron concentration, when the initial count of the antagonist was 100 to 1, 000 times greater that of the fish pathogen. These in vitro results were successfully repeated in vivo. A probiotic effect in vivo was tested by exposing rainbow trout (Oncorynchus mykiss Walbaum) to P. fluorescens AH2 at a density of 10(5) CFU/ml for 5 days before a challenge with V. anguillarum at 10(4) to 10(5) CFU/ml for 1 h. Some fish were also exposed to P. fluorescens AH2 at 10(7) CFU/ml during the 1-h infection. The combined probiotic treatment resulted in a 46% reduction of calculated accumulated mortality; accumulated mortality was 25% after 7 days at 12 degrees C in the probiotic-treated fish, whereas mortality was 47% in fish not treated with the probiont.
427 citations
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TL;DR: FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN.
Abstract: Pauci-immune focal necrotizing glomerulonephritis (FNGN) is a severe inflammatory disease associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA). Here we characterize autoantibodies to lysosomal membrane protein-2 (LAMP-2) and show that they are a new ANCA subtype present in almost all individuals with FNGN. Consequently, its prevalence is nearly twice that of the classical ANCAs that recognize myeloperoxidase or proteinase-3. Furthermore, antibodies to LAMP-2 cause pauci-immune FNGN when injected into rats, and a monoclonal antibody to human LAMP-2 (H4B4) induces apoptosis of human microvascular endothelium in vitro. The autoantibodies in individuals with pauci-immune FNGN commonly recognize a human LAMP-2 epitope (designated P(41-49)) with 100% homology to the bacterial adhesin FimH, with which they cross-react. Rats immunized with FimH develop pauci-immune FNGN and also develop antibodies to rat and human LAMP-2. Finally, we show that infections with fimbriated pathogens are common before the onset of FNGN. Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN.
427 citations
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TL;DR: It is demonstrated that the organ distribution of silver was similar when AgNPs or AgAc were administered orally to rats, and the presence of silver granules containing selenium and sulfur in the intestinal wall of rats exposed to either of the silver forms suggests a common mechanism of their formation.
Abstract: Background
The study investigated the distribution of silver after 28 days repeated oral administration of silver nanoparticles (AgNPs) and silver acetate (AgAc) to rats. Oral administration is a relevant route of exposure because of the use of silver nanoparticles in products related to food and food contact materials.
427 citations
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TL;DR: A numerical study of the transient acoustophoretic motion of microparticles suspended in a liquid-filled microchannel and driven by the acoustic forces arising from an imposed standing ultrasound wave shows the transition in the acoustrophoretic particle motion from being dominated by streaming-induced drag tobeing dominated by radiation forces as a function of particle size, channel geometry, and material properties.
Abstract: We present a numerical study of the transient acoustophoretic motion of microparticles suspended in a liquid-filled microchannel and driven by the acoustic forces arising from an imposed standing ultrasound wave: the acoustic radiation force from the scattering of sound waves on the particles and the Stokes drag force from the induced acoustic streaming flow. These forces are calculated numerically in two steps. First, the thermoacoustic equations are solved to first order in the imposed ultrasound field taking into account the micrometer-thin but crucial thermoviscous boundary layer near the rigid walls. Second, the products of the resulting first-order fields are used as source terms in the time-averaged second-order equations, from which the net acoustic forces acting on the particles are determined. The resulting acoustophoretic particle velocities are quantified for experimentally relevant parameters using a numerical particle-tracking scheme. The model shows the transition in the acoustophoretic particle motion from being dominated by streaming-induced drag to being dominated by radiation forces as a function of particle size, channel geometry, and material properties.
427 citations
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TL;DR: In this paper, the van der Waals density functional (vdW-DF) was used to study the adsorption of graphene on Co, Ni, Pd, Ag, Au, Cu, Pt, and Al(111) surfaces.
Abstract: We use density functional theory (DFT) with a recently developed van der Waals density functional (vdW-DF) to study the adsorption of graphene on Co, Ni, Pd, Ag, Au, Cu, Pt, and Al(111) surfaces. In contrast to the local-density approximation (LDA) which predicts relatively strong binding for Ni,Co, and Pd, the vdW-DF predicts weak binding for all metals and metal-graphene distances in the range $3.40--3.72\text{ }\text{\AA{}}$. At these distances the graphene band structure as calculated with DFT and the many-body ${G}_{0}{W}_{0}$ method is basically unaffected by the substrate, in particular there is no opening of a band gap at the $K$ point.
426 citations
Authors
Showing all 24555 results
Name | H-index | Papers | Citations |
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Peer Bork | 206 | 697 | 245427 |
Jens K. Nørskov | 184 | 706 | 146151 |
Jens Nielsen | 149 | 1752 | 104005 |
Bernhard O. Palsson | 147 | 831 | 85051 |
Jian Yang | 142 | 1818 | 111166 |
Kim Overvad | 139 | 1196 | 86018 |
Bernard Henrissat | 139 | 593 | 100002 |
Torben Jørgensen | 135 | 883 | 86822 |
Joel N. Hirschhorn | 133 | 431 | 101061 |
John W. Hutchinson | 129 | 419 | 74747 |
Robert J. Cava | 125 | 1042 | 71819 |
Robert A. Harrington | 124 | 789 | 68023 |
Hans Ulrik Nørgaard-Nielsen | 124 | 295 | 84595 |
M. Linden-Vørnle | 120 | 235 | 80049 |
Allan Hornstrup | 118 | 328 | 83519 |