Institution
Technical University of Denmark
Education•Kongens Lyngby, Hovedstaden, Denmark•
About: Technical University of Denmark is a education organization based out in Kongens Lyngby, Hovedstaden, Denmark. It is known for research contribution in the topics: Population & Catalysis. The organization has 24126 authors who have published 66394 publications receiving 2443649 citations. The organization is also known as: Danmarks Tekniske Universitet & DTU.
Topics: Population, Catalysis, Wind power, Computer science, Laser
Papers published on a yearly basis
Papers
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TL;DR: The difference in predictive performance between the neural network methods and that of the matrix‐driven methods is found to be most significant for peptides that bind strongly to the HLA molecule, confirming that the signal of higher order sequence correlation is most strongly present in high‐binding peptides.
Abstract: In this paper we describe an improved neural network method to predict T-cell class I epitopes. A novel input representation has been developed consisting of a combination of sparse encoding, Blosum encoding, and input derived from hidden Markov models. We demonstrate that the combination of several neural networks derived using different sequence-encoding schemes has a performance superior to neural networks derived using a single sequence-encoding scheme. The new method is shown to have a performance that is substantially higher than that of other methods. By use of mutual information calculations we show that peptides that bind to the HLA A*0204 complex display signal of higher order sequence correlations. Neural networks are ideally suited to integrate such higher order correlations when predicting the binding affinity. It is this feature combined with the use of several neural networks derived from different and novel sequence-encoding schemes and the ability of the neural network to be trained on data consisting of continuous binding affinities that gives the new method an improved performance. The difference in predictive performance between the neural network methods and that of the matrix-driven methods is found to be most significant for peptides that bind strongly to the HLA molecule, confirming that the signal of higher order sequence correlation is most strongly present in high-binding peptides. Finally, we use the method to predict T-cell epitopes for the genome of hepatitis C virus and discuss possible applications of the prediction method to guide the process of rational vaccine design.
1,010 citations
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TL;DR: It is demonstrated that the phase behaviour of phosphatidylcholine-cholesterol mixtures can be rationalized using only a few basic assumptions, suggesting that the occurrence of specific phosphatido-ch cholesterol complexes is not implied by the experimental thermodynamic data.
1,004 citations
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TL;DR: In this paper, a new group contribution method for the estimation of properties of pure organic compounds is presented, which is performed at two levels: the basic level uses contributions from first-order groups, while the next higher level uses a small set of second order groups having the first order groups as building blocks.
Abstract: A new group contribution method for the estimation of properties of pure organic compounds is presented. Estimation is performed at two levels: the basic level uses contributions from first-order groups, while the next higher level uses a small set of second-order groups having the first-order groups as building blocks. Thus, the method provides both a first-order approximation (first-order group contributions) and a more accurate second-order prediction (first- and second-order group contributions). This article discusses methods for prediction of normal boiling point, normal melting point, critical pressure, critical temperature, critical volume, standard enthalpy of vaporization at 298 K, standard Gibbs energy, and standard enthalpy of formation at 298 K. The predictions are based exclusively on the molecular structure of the compound, and the method is able to distinguish among isomers. Compared to the currently-used methods, this technique demonstrates significant improvements in accuracy and applicability.
1,003 citations
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TL;DR: Based on density functional theory calculations, kinetic measurements, microkinetic and Monte Carlo simulations, thermogravimetric analysis (TGA) experiments, extended X-ray absorption spectroscopy (EXAFS) measurements, and experimental results from the literature, this paper presented a detailed and comprehensive mechanistic picture of the steam reforming process on a Ni catalyst.
1,002 citations
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TL;DR: Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations.
1,000 citations
Authors
Showing all 24555 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peer Bork | 206 | 697 | 245427 |
Jens K. Nørskov | 184 | 706 | 146151 |
Jens Nielsen | 149 | 1752 | 104005 |
Bernhard O. Palsson | 147 | 831 | 85051 |
Jian Yang | 142 | 1818 | 111166 |
Kim Overvad | 139 | 1196 | 86018 |
Bernard Henrissat | 139 | 593 | 100002 |
Torben Jørgensen | 135 | 883 | 86822 |
Joel N. Hirschhorn | 133 | 431 | 101061 |
John W. Hutchinson | 129 | 419 | 74747 |
Robert J. Cava | 125 | 1042 | 71819 |
Robert A. Harrington | 124 | 789 | 68023 |
Hans Ulrik Nørgaard-Nielsen | 124 | 295 | 84595 |
M. Linden-Vørnle | 120 | 235 | 80049 |
Allan Hornstrup | 118 | 328 | 83519 |