Institution
Technical University of Denmark
Education•Kongens Lyngby, Hovedstaden, Denmark•
About: Technical University of Denmark is a education organization based out in Kongens Lyngby, Hovedstaden, Denmark. It is known for research contribution in the topics: Population & Catalysis. The organization has 24126 authors who have published 66394 publications receiving 2443649 citations. The organization is also known as: Danmarks Tekniske Universitet & DTU.
Topics: Population, Catalysis, Wind power, Computer science, Laser
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors present a methodology for optimal shape design based on homogenization, which is related to modern production techniques and consists of computing the optimal distribution in space of an anisotropic material that is constructed by introducing an infimum of periodically distributed small holes in a given homogeneous, i.i.
Abstract: Optimal shape design of structural elements based on boundary variations results in final designs that are topologically equivalent to the initial choice of design, and general, stable computational schemes for this approach often require some kind of remeshing of the finite element approximation of the analysis problem. This paper presents a methodology for optimal shape design where both these drawbacks can be avoided. The method is related to modern production techniques and consists of computing the optimal distribution in space of an anisotropic material that is constructed by introducing an infimum of periodically distributed small holes in a given homogeneous, i~otropic material, with the requirement that the resulting structure can carry the given loads as well as satisfy other design requirements. The computation of effective material properties for the anisotropic material is carried out using the method of homogenization. Computational results are presented and compared with results obtained by boundary variations.
5,858 citations
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TL;DR: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates, and there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries.
5,802 citations
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University of Évry Val d'Essonne1, Institut national de la recherche agronomique2, Technical University of Denmark3, Barcelona Supercomputing Center4, University of Copenhagen5, University of Tokyo6, University of Miyazaki7, Wageningen University and Research Centre8, Tokyo Institute of Technology9, French Alternative Energies and Atomic Energy Commission10
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
Abstract: Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.
5,566 citations
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TL;DR: A new method for the identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequence that performs significantly better than previous prediction schemes and can easily be applied on genome-wide data sets.
Abstract: We have developed a new method for the identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequence. The method performs significantly better than previous prediction schemes and can easily be applied on genome-wide data sets. Discrimination between cleaved signal peptides and uncleaved N-terminal signal-anchor sequences is also possible, though with lower precision. Predictions can be made on a publicly available WWW server.
5,480 citations
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TL;DR: Results from running RNAmmer on a large set of genomes indicate that the location of rRNAs can be predicted with a very high level of accuracy.
Abstract: The publication of a complete genome sequence is usually accompanied by annotations of its genes. In contrast to protein coding genes, genes for ribosomal RNA (rRNA) are often poorly or inconsistently annotated. This makes comparative studies based on rRNA genes difficult. We have therefore created computational predictors for the major rRNA species from all kingdoms of life and compiled them into a program called RNAmmer. The program uses hidden Markov models trained on data from the 5S ribosomal RNA database and the European ribosomal RNA database project. A pre-screening step makes the method fast with little loss of sensitivity, enabling the analysis of a complete bacterial genome in less than a minute. Results from running RNAmmer on a large set of genomes indicate that the location of rRNAs can be predicted with a very high level of accuracy. Novel, unannotated rRNAs are also predicted in many genomes. The software as well as the genome analysis results are available at the CBS web server.
4,949 citations
Authors
Showing all 24555 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peer Bork | 206 | 697 | 245427 |
Jens K. Nørskov | 184 | 706 | 146151 |
Jens Nielsen | 149 | 1752 | 104005 |
Bernhard O. Palsson | 147 | 831 | 85051 |
Jian Yang | 142 | 1818 | 111166 |
Kim Overvad | 139 | 1196 | 86018 |
Bernard Henrissat | 139 | 593 | 100002 |
Torben Jørgensen | 135 | 883 | 86822 |
Joel N. Hirschhorn | 133 | 431 | 101061 |
John W. Hutchinson | 129 | 419 | 74747 |
Robert J. Cava | 125 | 1042 | 71819 |
Robert A. Harrington | 124 | 789 | 68023 |
Hans Ulrik Nørgaard-Nielsen | 124 | 295 | 84595 |
M. Linden-Vørnle | 120 | 235 | 80049 |
Allan Hornstrup | 118 | 328 | 83519 |