Technical University of Denmark

About: Technical University of Denmark is a education organization based out in Kongens Lyngby, Hovedstaden, Denmark. It is known for research contribution in the topics: Population & Catalysis. The organization has 24126 authors who have published 66394 publications receiving 2443649 citations. The organization is also known as: Danmarks Tekniske Universitet & DTU.

Whole-genome analyses resolve early branches in the tree of life of modern birds

Abstract: To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergence in Neoaves, two groups we named Passerea and Columbea, representing independent lineages of diverse and convergently evolved land and water bird species. Among Passerea, we infer the common ancestor of core landbirds to have been an apex predator and confirm independent gains of vocal learning. Among Columbea, we identify pigeons and flamingoes as belonging to sister clades. Even with whole genomes, some of the earliest branches in Neoaves proved challenging to resolve, which was best explained by massive protein-coding sequence convergence and high levels of incomplete lineage sorting that occurred during a rapid radiation after the Cretaceous-Paleogene mass extinction event about 66 million years ago.

Multilocus Sequence Typing of Total-Genome-Sequenced Bacteria

Abstract: Accurate strain identification is essential for anyone working with bacteria. For many species, multilocus sequence typing (MLST) is considered the “gold standard” of typing, but it is traditionally performed in an expensive and time-consuming manner. As the costs of whole-genome sequencing (WGS) continue to decline, it becomes increasingly available to scientists and routine diagnostic laboratories. Currently, the cost is below that of traditional MLST. The new challenges will be how to extract the relevant information from the large amount of data so as to allow for comparison over time and between laboratories. Ideally, this information should also allow for comparison to historical data. We developed a Web-based method for MLST of 66 bacterial species based on WGS data. As input, the method uses short sequence reads from four sequencing platforms or preassembled genomes. Updates from the MLST databases are downloaded monthly, and the best-matching MLST alleles of the specified MLST scheme are found using a BLAST-based ranking method. The sequence type is then determined by the combination of alleles identified. The method was tested on preassembled genomes from 336 isolates covering 56 MLST schemes, on short sequence reads from 387 isolates covering 10 schemes, and on a small test set of short sequence reads from 29 isolates for which the sequence type had been determined by traditional methods. The method presented here enables investigators to determine the sequence types of their isolates on the basis of WGS data. This method is publicly available at www.cbs.dtu.dk/services/MLST.

The relation between crack growth resistance and fracture process parameters in elastic-plastic solids

Abstract: CKA~K growth initiation and subsequent resistance is computed for an elastic-plastic solid with an idealized traction separation law specified on the crack plane to characterize the fracture process. The solid is specified by its Young’s modulus, E, Poisson’s ratio, v, initial tensile yield stress, (or, and strain hardening exponent, N. The primary parameters specifying the traction-separation law of the fracture process are the work of separation per unit area, To. and the peak traction, 6. Highly refined calculations have been carried out for resistance curves. K,(Arr), for plane strain, mode I growth in small-scale yielding as dependent on the parameters characterizing the elastic-plastic properties of the solid and its fracture process. With K,, = [El-,/( I ~ v’)] ’ 2 as the intensity needed to advance the crack in the absence ofplasticity, K,J& is presented in terms of its dependence on the two most important parameters, d/nr and N, with special emphasis on initiation toughness and steady-state toughness, Three applications of the results are made : to predict toughnesss when the fracture process is void growth and coalescence, to predict the role of plasticity on interface toughness for similar materials bonded together, and to illuminate the role of plasticity in enhancing toughness in dual-phase solids. The regime of applicability of the present model to ductile fracture due to void growth and coalescence, wherein multiple voids interact within the fracture process zone, is complementary to the regime of applicability of models describing the interaction between a single void and the crack tip. The two mechanism regimes are delineated and the consequence of a transition between them is discussed.

Revealing the Maximum Strength in Nanotwinned Copper

Abstract: [Lu, L.; Chen, X.; Lu, K.] Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China. [Huang, X.] Tech Univ Denmark, Riso Natl Lab Sustainable Energy, Ctr Fundamental Res Met Struct Four Dimens, Dept Mat Res, DK-4000 Roskilde, Denmark.;Lu, L (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China;llu@imr.ac.cn