Universidad Manuela Beltrán

About: Universidad Manuela Beltrán is a education organization based out in Bogotá, Colombia. It is known for research contribution in the topics: Population & Body mass index. The organization has 690 authors who have published 611 publications receiving 2526 citations.

Benzodiazepines: Their Use either as Essential Medicines or as Toxics Substances.

Abstract: This review highlights the nature, characteristics, properties, pharmacological differences between different types of benzodiazepines, the mechanism of action in the central nervous system, and the degradation of benzodiazepines In the end, the efforts to reduce the benzodiazepines' adverse effects are shown and a reflection is made on the responsible uses of these medications

Adiposidad corporal y su relación con componentes del síndrome metabólico en adultos de bogotá, colombia

Abstract: Objective: recently, Bergman et al. have introduced a new index of adiposity, namely, body adiposity index (BAI), as a marker of obesity excess body fat in clinical practice. We aimed to determine the prevalence of obesity and metabolic syndrome (MetS) and to assess the predicting ability of BAI in various atherogenic indices, MetS and its components among adult from Bogota, Colombia. Methods: cross-sectional study in 690 male. MetS components (waist circumference ≥ 90 cm; fasting plasma glucose ≥ 100 mg/dL, blood pressure ≥ 135/85 mm Hg; triglycerides ≥ 150 mg/dL and HDL-c ≤ 40 mg/dL were measured. Atherogenic indices (cholesterol/HDL-c, LDL-c/HDL-c, triglycerides/HDL-c, lipid-metabolic index [LMI] and MetS score) were calculated. Results: the prevalence of obesity by BAI (cut-point > 26.1%) and MetS was 50.1% and 19.1%, respectively. Subjects with MetS and obesity by BAI, show lower HDL-c levels and more frequently components of MetS (waist circumference, cholesterol and serum triglycerides). Predicting ability of BAI with a greater odds for atherogenic indices were 1.78 (95%CI 1.25 to 2.55), 1.46 (95%CI 1.01 to 2.14), 1.97 (95% 1.29 to 3.02), 2.04 (95%CI 1.23 to 3.39) and 1.47 (95%CI 1.03 to 2.11), elevation in LDL-c, LMI, MetS score and cholesterol/ HDL-c, and triglyceride/HDL-c, respectively (p < 0.05). Conclusion: subjects with higher levels of BAI show raised prevalence of obesity and positively associated with components of MetS.

Synthesis and cytotoxic evaluation of novel 2-aryl-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroquinolines, podophyllotoxin-like molecules

Abstract: Diverse 2-aryl-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-6,7-methylendioxy-1,2,3,4-tetrahydroquinolines (DM series) were synthesized using three-component reaction of 3,4-methylendioxyaniline, benzaldehydes and isoeugenol. Purified and characterized tetrahydroquinoline molecules were tested in vitro for potential antitumor and cytotoxic activities. It was observed a strong relationship between selective cytotoxic activity on U937 and HeLa cells and the substitutions presented in aryl ring of position C-2 of the synthesized tetrahydroquinoline derivatives. Tested molecules, called DM108, DM116 and DM118, resulted in active compounds having a greater SI compared with colchicine and doxorubicin, reference compounds.

Factors associated with active commuting to school by bicycle from Bogotá, Colombia: The FUPRECOL study.

Abstract: Background Active commuting to school (ACS) can contribute to daily physical activity (PA) levels in children and adolescents. The aim of the study was to analyze the characteristics of active commuting to and from school by bicycle and to identify the factors associated with the use of bicycles for active commuting to school based in a sample of schoolchildren in Bogota, Colombia.

Association of Muscular Fitness and Body Fatness with Cardiometabolic Risk Factors: The FUPRECOL Study.

Abstract: This study investigated the associations of muscular fitness and various indicators of body fatness with cardio-metabolic risk factors and determined the muscular strength and body fatness thresholds for detecting a high risk of cardio-metabolic dysfunction in young adults. A cross-sectional study was conducted on 1798 collegiate students (61.5% females, mean age 20.5 years). Muscular fitness was determined by using a handgrip strength test and normalized grip strength (NGS = handgrip (kg)/body mass (kg)). Body mass index (BMI), waist circumference (WC), percentage of fat mass (BF%), fat-mass index (FMI), and waist-to-height ratio (WHR) were also included as body fatness measurements. A high cardio-metabolic risk cluster was derived by assessing triglycerides, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, fasting glucose, and blood pressure. Logistic regression models showed that men and women with lower NGS had an increased cardio-metabolic risk odds ratio (OR) = 1.8, 95% confidence interval (CI) 1.1 to 2.9, p = 0.006, and OR = 1.6, 95% CI 1.0 to 2.5, p = 0.036, respectively). In both sexes, higher levels of all fatness parameters were also associated with increased cardio-metabolic risk (p < 0.001). In both men and women, high FMI had the highest OR for clustered risk (OR = 4.7, 95% CI 2.6 to 8.4, and OR = 7.3, 95% CI 3.4 to 9.7, p < 0.001, respectively). Combined analysis showed that unfitness (lower NGS) and high fat had the highest OR for WC and FMI in men and women, respectively (OR = 5.5, 95% CI 2.6 to 11.4, OR = 7.7, 95% CI 2.3 to 15.8, p < 0.01). Muscular strength and body fatness are independently and jointly associated with increased cardiometabolic risk in young adults, which suggests that both are predictor variables for this.