Universidade Federal de Santa Maria

About: Universidade Federal de Santa Maria is a education organization based out in Santa Maria, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 21178 authors who have published 35632 publications receiving 371665 citations.

Ebselen attenuates haloperidol-induced orofacial dyskinesia and oxidative stress in rat brain.

Abstract: Haloperidol-induced orofacial dyskinesia is an animal model of tardive dyskinesia whose pathophysiology has been related to basal ganglia oxidative stress. In this study the authors examined whether ebselen, an antioxidant organochalcogen with glutatione peroxidase-like activity, changes the behavioral and neurochemical effect of sub-chronic haloperidol administration. Haloperidol administered (12 mg/kg/week, sc) for 4 weeks caused a significant increase in vacuous chewing movements (VCMs), tongue protrusion (TP) and the duration of facial twitching (FT) observed in 4 weekly evaluations (p < 0.05). Ebselen (30 mg/kg, ip), administered every other day, along with haloperidol (12 mg/kg/week, sc) once weekly, reversed the increase of VCMs and FT in four weekly evaluations (p < 0.05), while TP frequency was reverted in the 2nd, 3rd, and 4th week. After the treatments and behavioral observation, biochemical parameters in segments of the brain were analyzed. Haloperidol significantly increased the thiobarbituric acid-reactive species (TBARS) levels in the cortex, striatum and subcortical parts of the brain. The co-administration of ebselen reversed the effect of haloperidol on TBARS production in cortex and striatum. The results of the present study clearly indicate that ebselen has a protective role against haloperidol-induced orofacial dyskinesia and reverses the increase in TBARS production caused by haloperidol administration. Consequently, the use of ebselen as a therapeutic agent for the treatment of tardive dyskinesia should be considered.

Empoderamento da mulher cuidadora de crianças com necessidades especiais de saúde

Abstract: A demanda de cuidados as criancas com necessidades especiais de saude promove desgaste fisico e mental da cuidadora. Para analisar as implicacoes dessas demandas sobre o empoderamento da cuidadora, desenvolveu-se uma pesquisa qualitativa. Onze cuidadoras acompanhantes, de um hospital do sul do Brasil, foram organizadas em tres grupos, entre 2004-2005. Utilizou-se a analise de discurso no relatorio de tres dinâmicas do metodo criativo-sensivel. O empoderamento individual das cuidadoras foi construido no enfrentamento das situacoes-limites dos cuidados e no encontro com os profissionais de saude. O papel de boa mae e de cuidadoras dedicadas, abnegadas levou-as a abdicar de sua condicao feminina, gerando isolamento social, sofrimento e estresse. O empoderamento individual opressivo as distanciou do empoderamento coletivo libertador; a cuidadora foi valorizada em sua condicao materna e nao na feminina. As praticas de empoderamento individual, centradas na abnegacao e dedicacao, possibilitam a reflexao e acao no processo de empoderamento coletivo.