Institution
Universidade Federal de Santa Maria
Education•Santa Maria, Brazil•
About: Universidade Federal de Santa Maria is a education organization based out in Santa Maria, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 21178 authors who have published 35632 publications receiving 371665 citations.
Papers published on a yearly basis
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01 Jan 2006TL;DR: This chapter contains sections titled: Introduction Principles of Power Injection Instantaneous Active and Reactive Power Control Approach Integration of Multiple Renewable Energy Sources Islanding and Interconnection Control DG Control and Power In injection References.
Abstract: This chapter contains sections titled: Introduction Principles of Power Injection Instantaneous Active and Reactive Power Control Approach Integration of Multiple Renewable Energy Sources Islanding and Interconnection Control DG Control and Power Injection References
518 citations
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TL;DR: The data indicate that mitochondrial reorganization and ATP levels are different between morphologically good and poor oocytes and may be responsible for their different developmental capacity after IVF.
Abstract: In this study, we evaluated mitochondrial distribution and ATP content of individual bovine oocytes before and after in vitro maturation (IVM). Cumulus-oocyte complexes were classified according to morphological criteria: category 1, homogeneous oocyte cytoplasm, compact multilayered cumulus oophorus; category 2, cytoplasm with small inhomogeneous areas, more than five layers of compact cumulus; category 3, heterogeneous/vacuolated cytoplasm, three to five layers of cumulus including small areas of denuded zona pellucida; category 4, heterogeneous cytoplasm, completely or in great part denuded. In immature oocytes, staining with MitoTracker green revealed mitochondrial clumps in the periphery of the cytoplasm, with a strong homogenous signal in category 1 oocytes, a weaker staining in category 2 oocytes, allocation of mitochondria around vacuoles in category 3 oocytes, and poor staining of mitochondria in category 4 oocytes. After IVM, mitochondrial clumps were allocated more toward the center, became larger, and stained more intensive in category 1 and 2 oocytes. This was also true for category 3 oocytes; however, mitochondria maintained their perivacuolar distribution. No mitochondrial reorganization was seen for category 4 oocytes. Before IVM, the average ATP content of category 1 oocytes (1.8 pmol) tended to be higher than that of category 2 oocytes (1.6 pmol) and was significantly (P < 0.01) higher than in category 3 (1.4 pmol) and 4 oocytes (0.9 pmol). The IVM resulted in a significant (P < 0.01) increase in the average ATP content of all oocyte categories, with no difference between oocytes extruding versus nonextruding a polar body. After in vitro fertilization (IVF) and culture, significantly (P < 0.05) more category 1 and 2 than category 3 and 4 oocytes developed to the morula or blastocyst stage (determined 168 h after IVF). Total cell numbers of expanded blastocysts derived from category 1 and 2 oocytes were significantly (P < 0.05) higher than of those originating from category 3 and 4 oocytes. These data indicate that mitochondrial reorganization and ATP levels are different between morphologically good and poor oocytes and may be responsible for their different developmental capacity after IVF.
481 citations
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TL;DR: Findings indicate that alpha-humulene and (-)-trans-caryophyllene, derived from the essential oil of C. verbenacea, might represent important tools for the management and/or treatment of inflammatory diseases.
473 citations
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TL;DR: The paucity of in human studies limits the potential of essential oils as effective and safe phytotherapeutic agents, and more well-designed clinical trials are needed in order to ascertain the real efficacy and safety of these plant products.
Abstract: Essential oils are complex mixtures of hydrocarbons and their oxygenated derivatives arising from two different isoprenoid pathways. Essential oils are produced by glandular trichomes and other secretory structures, specialized secretory tissues mainly diffused onto the surface of plant organs, particularly flowers and leaves, thus exerting a pivotal ecological role in plant. In addition, essential oils have been used, since ancient times, in many different traditional healing systems all over the world, because of their biological activities. Many preclinical studies have documented antimicrobial, antioxidant, anti-inflammatory and anticancer activities of essential oils in a number of cell and animal models, also elucidating their mechanism of action and pharmacological targets, though the paucity of in human studies limits the potential of essential oils as effective and safe phytotherapeutic agents. More well-designed clinical trials are needed in order to ascertain the real efficacy and safety of these plant products.
456 citations
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Samsung Medical Center1, Peking University2, Cornell University3, Harvard University4, University of Montpellier5, Shanghai Jiao Tong University6, University of Ulsan7, Yonsei University8, Chang Gung University9, Prince of Songkla University10, Universidade Federal de Santa Maria11, Roswell Park Cancer Institute12, Kagawa University13, Merck & Co.14
TL;DR: In this paper, the authors compared pembrolizumab plus chemotherapy versus chemotherapy alone as a first-line treatment for advanced oesophageal cancer and Siewert type 1 gastro-oesophagesphageal junction cancer.
451 citations
Authors
Showing all 21330 results
Name | H-index | Papers | Citations |
---|---|---|---|
João Rocha | 93 | 1521 | 49472 |
Jose Rodriguez | 93 | 803 | 58176 |
Christian C. Abnet | 86 | 413 | 29165 |
Thaisa Storchi-Bergmann | 70 | 318 | 22817 |
Ali Emadi | 69 | 660 | 24174 |
Luis S. Pereira | 68 | 317 | 35582 |
Diogo O. Souza | 68 | 534 | 17793 |
Adair R.S. Santos | 63 | 329 | 14529 |
Ahmad Awada | 61 | 547 | 16109 |
Farin Kamangar | 61 | 237 | 16554 |
Stefan Laufer | 59 | 481 | 11158 |
Cristina W. Nogueira | 59 | 503 | 16655 |
Ana Lúcia S. Rodrigues | 58 | 244 | 10187 |
Julia F. Ridpath | 57 | 229 | 9543 |
Ludger A. Wessjohann | 53 | 513 | 11405 |